Abstract:
:An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The absolute configuration was also confirmed by X-ray crystal analysis.
journal_name
Steroidsjournal_title
Steroidsauthors
Jia P,Wu X,Yu Y,Zhang Gdoi
10.1016/j.steroids.2008.10.018subject
Has Abstractpub_date
2009-02-01 00:00:00pages
229-32issue
2eissn
0039-128Xissn
1878-5867pii
S0039-128X(08)00277-8journal_volume
74pub_type
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