Abstract：
OBJECTIVE:Abnormal secretion of thyroid hormones, growth hormone, cortisol and androgens influences body composition. We hypothesised that higher cortisol excretion, in combination with higher androgen and IGF-I concentrations, had a synergistic, favourable effect on body mass and bone. DESIGN, PATIENTS AND METHODS:This was a cross-sectional study on a population sample of 290 women and 93men. The mean age was 65.4±7.2yearsinwomen and 59.7±10.0yearsinmen. Body composition was assessed with bioimpedance, and skeletal health with calcaneal quantitative ultrasound and fracture rate. The influence of urinary free cortisol (UFC), serum DHEAs (women), testosterone (men), free T4andIGF-I on the outcome was studied with regression analyses adjusted for age and body mass index. RESULTS:In women, higher concentrations of UFC, DHEAs, IGF-I and lower free T4, were associated with higher fat-free mass. Only a higher UFC concentration was associated with favourable calcaneal measurements. In men, higher testosterone was associated with higher fat-free mass and lower fat mass. Higher IGF-I concentration, but not UFC, was independently associated with higher fat-free mass in men. Interaction analyses did not reveal any additive effects of hormones on body composition or bone in either sex. In both men and women, only age was associated with osteoporotic fractures. CONCLUSION:Serum concentrations of androgens together with IGF-I were positively associated with body composition in both sexes. Urinary cortisol was positively associated with fat-free mass and bone status in women only. Increasing age, but not hormones, was the major determinant of osteoporotic fractures in this population sample.
journal_name
Steroidsjournal_title
Steroidsauthors
Ragnarsson O,Trimpou P,Oleröd G,Landin-Wilhelmsen Kdoi
10.1016/j.steroids.2016.09.006subject
Has Abstractpub_date
2016-11-01 00:00:00pages
154-159eissn
0039-128Xissn
1878-5867pii
S0039-128X(16)30121-0journal_volume
115pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:Synthesis of 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-hydroxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = H) and 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-methoxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = Me) have been carried out by Friedel-Crafts reaction on 3 beta,7,17 beta-trihydroxy-androst-5-ene...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(95)00007-d
更新日期：1995-06-01 00:00:00
abstract：:At the development of receptivity the endometrium undergoes specific changes. Several factors have been suggested as markers of endometrial receptivity. A common feature for most of these factors is that they are directly, or indirectly, regulated by progesterone. The effect of various doses and regimens of mifepristo...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/s0039-128x(03)00131-4
更新日期：2003-11-01 00:00:00
abstract：:The synthesis of the esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) with three bile acids and of the cholesteryl carbonate of norethisterone are described. :This article reports the synthesis of the esters of norethisterone (17 alpha-ethynl-17beta-hydroxyestr-4-en-3-one) with 3 bile acids ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(83)90103-4
更新日期：1983-03-01 00:00:00
abstract：:Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to pregnenolone nor progesterone to corticoid hormones. When given orally to rats, trilostane inhibits corticosterone and aldo...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90010-7
更新日期：1978-09-01 00:00:00
abstract：:The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.01.006
更新日期：2016-03-01 00:00:00
abstract：:Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers bearing these signaling proteins. To assess these growth-promoting pathways, we undertook controlled homogenization and fractionation of NIH-H23 non-small cell...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2005.02.017
更新日期：2005-05-01 00:00:00
abstract：:Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2003.08.016
更新日期：2003-12-01 00:00:00
abstract：:The accurate analysis of trace components in complex biological matrices requires the use of reliable internal standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled analogues of the analyte molecules are the most appropriate internal standards. In this paper the synthesis of the 3...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.08.007
更新日期：2012-11-01 00:00:00
abstract：:A radioimmunoassay (RIA) method is described for the determination of 4-androstene-3, 11, 17-trione (11-oxo-androstenedione) in human plasma. 4-androstene-3, 11, 17-trione 3-(0-carboxymethyl) oxime-bovine serum albumin conjugate was used to generate highly specific antiserum in rabbits. Cross reactivities of several o...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(84)80013-6
更新日期：1984-07-01 00:00:00
abstract：:Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.01.004
更新日期：2016-07-01 00:00:00
abstract：:There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2005.02.005
更新日期：2005-05-01 00:00:00
abstract：:Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2017.05.001
更新日期：2017-08-01 00:00:00
abstract：:The in vivo retention of 3-H-testosterone, dihydrotestosterone (DHT), 3alpha-androstanediol (3alpha-DIOL), 3beta-DIOL, androstenedione, progesterone and cortisol by renal cytoplasm and nuclei of male and female mice was studied. Testosterone was the major androgen isolated from cytoplasm and nuclei following testoster...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(75)80011-0
更新日期：1975-01-01 00:00:00
abstract：:Based on histological criteria, Kingsley and Bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. In contrats, Kennedy (4) found in estrogen-pretreated rats that ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(76)90061-1
更新日期：1976-03-01 00:00:00
abstract：:The potent antiproliferative effect of progestins has been utilized in clinical regimens for treatment of endometrial proliferative disorders. The progestin infiltrated intrauterine device used as therapy for endometrial carcinoma as well as endometrial hyperplasia yields a hundred-fold increase of local progestin con...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.09.010
更新日期：2008-01-01 00:00:00
abstract：:15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 mi...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(78)80002-6
更新日期：1978-05-01 00:00:00
abstract：:A new synthesis of both epimeric forms of 26-cholestanoic acids and 26-alcohols containing a 3beta-hydroxy-Delta(5)- or a Delta(4)-3-keto-functionality in ring A is described starting from stigmasterol or (20S)-3beta-acetoxy-pregn-5-en-20-carboxylic acid. The obtained compounds are useful as standards for studies of c...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2005.02.014
更新日期：2005-07-01 00:00:00
abstract：:Radioactive mestranol (ME) and/or ethynylestradiol (EE) were administered to women in Nigeria, Sri Lanka, and the USA, and the types and patterns of radioactive urinary conjugates examined by Sephadex LH-20 chromatography. There are no differences in the total excretion of urinary radioactivity over 3 days. Consistent...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(80)90001-x
更新日期：1980-09-01 00:00:00
abstract：:Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.05.019
更新日期：2004-09-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) supplementation has been anecdotally considered as a tool to improve body composition and health status. We aimed to verify the impact of DHEA supplementation on traditional measurements of body composition and blood pressure (BP) due to their clinical applicability. A meta-analysis of ra...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2020.108710
更新日期：2020-11-01 00:00:00
abstract：:The first natural occurrence of 19-norcholestenone is reported, together with 17 sterols and one other delta 4-3-ketone in the extracts of the Californian gorgonian, Muricea californica (Aurivillius). Six additional demethyl sterols and five additional 4-monomethyl sterols which remain unidentified were also detected....
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(83)90093-4
更新日期：1983-04-01 00:00:00
abstract：:3 beta-Hydroxy-5-androsten-17-one is converted to 5-androstene-3, 17-dione by rat liver alcohol dehydrogenase (ADH). We have reported on the purity of the enzyme which is eluted with pyrazole as a single homogeneous protein using an AMP-agarose affinity column. Rat liver ADH can oxidize hydroxyl groups not only at 3 b...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(82)90079-4
更新日期：1982-11-01 00:00:00
abstract：:Estrogen plays a central role in the control of reproductive behaviour and in the regulation of neuroendocrine system. To elucidate the mechanism by which it controls the stress-modulated functions, it is important to understand how estrogenic effects are mediated. The distribution of estrogen receptor alpha (ERα) pro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2019.03.002
更新日期：2019-06-01 00:00:00
abstract：:The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(97)00075-5
更新日期：1997-11-01 00:00:00
abstract：:The use of the synthetic progestin medroxyprogesterone acetate (MPA) for estrus prevention in the dog can result in overproduction of growth hormone, suppression of plasma glucocorticoid levels, and the induction of mammary tumors. Proligestone (PROL) was claimed to be devoid of these unwanted side effects. In the pre...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(95)00216-d
更新日期：1996-03-01 00:00:00
abstract：:The therapeutic use of progesterone following traumatic brain injury has recently entered phase III clinical trials as a means of neuroprotection. Although it has been hypothesized that progesterone protects against calcium overload following excitotoxic shock, the exact mechanisms underlying the beneficial effects of...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.02.013
更新日期：2011-08-01 00:00:00
abstract：:Different phytoestrogens were tested as inhibitors of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17beta-HSDcl), a member of the short-chain dehydrogenase/reductase superfamily. Phytoestrogens inhibited the oxidation of 100microM 17beta-hydroxyestra-4-en-3-one and the reduction of 100micr...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2005.02.022
更新日期：2005-08-01 00:00:00
abstract：:The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(82)90018-6
更新日期：1982-10-01 00:00:00
abstract：:Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. The influence of steroids on inflammatory processes has long been established since glucocorticoids and their receptor belong to the regulatory network involved in inhibition of several inflamma...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2006.10.007
更新日期：2007-01-01 00:00:00
abstract：:Thyroid hormone receptors (TRs) are nuclear receptors that are activated by thyroid hormone ligands and co-regulator proteins. Two receptor subtypes, TRalpha and TRbeta, have been suggested to play a role in numerous physiological functions. However, specificity of receptor subtype function and co-regulator interactio...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2008.11.014
更新日期：2009-02-01 00:00:00
