Glucocorticosteroids as antioxidants in treatment of asthma and COPD. New application for an old medication?

Abstract:

:Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. The influence of steroids on inflammatory processes has long been established since glucocorticoids and their receptor belong to the regulatory network involved in inhibition of several inflammatory pathways. Inflammatory processes are usually accompanied by an increased oxidative burden followed by a depletion of antioxidants. Therefore, the effects of steroids on antioxidant status have been investigated revealing possible positive effects on the reduced antioxidant enzyme activity. Nevertheless, the mechanisms of this modulation have not been fully elucidated yet. It is possible that antioxidant enzyme activity is regulated at the level of transcription. Additionally, because of the fact that antioxidant enzymes are trace element dependent, steroids may affect their activity through influence on trace element accumulation. This review summarizes the effects of steroids on the antioxidant enzymes activity in vitro and in vivo in relation to asthma and COPD.

journal_name

Steroids

journal_title

Steroids

authors

Sadowska AM,Klebe B,Germonpré P,De Backer WA

doi

10.1016/j.steroids.2006.10.007

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

1-6

issue

1

eissn

0039-128X

issn

1878-5867

pii

S0039-128X(06)00215-7

journal_volume

72

pub_type

杂志文章,评审

相关文献

STEROIDS文献大全
  • Studies on the mechanism of action of 1 alpha,24-dihydroxyvitamin D3. III. The specific binding of 1 alpha,24-dihydroxyvitamin D3 to the receptor of chick parathyroid gland.

    abstract::Three protein fractions of the cytosol of the chick parathyroid glands, which had the sedimentation constants of 2.5 S, 3.7 S and 5.5 S, were found to bind with 1 alpha,25-dihydroxyvitamin D3. Among these proteins, the 3.7 S protein was assumed to be the specific receptor protein. The 3.7 S receptor protein was also ...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(82)90125-8

    authors: Ishizuka S,Bannai K,Naruchi T,Hashimoto Y

    更新日期:1982-01-01 00:00:00

  • A convenient strategy for the annulation of aryl scaffold to A/B-ring steroids under microwave irradiation.

    abstract::A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic keto...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2010.02.009

    authors: Barthakur MG,Hasib A,Gogoi J,Boruah RC

    更新日期:2010-06-01 00:00:00

  • Synthesis and biological activities of 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-1 alpha,25-dihydroxyvitamin D3.

    abstract::Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/s0039-128x(98)00072-5

    authors: Scheddin D,Mayer H,Schönecker B,Gliesing S,Reichenbächer M

    更新日期:1998-12-01 00:00:00

  • Estradiol, progesterone and genistein differentially regulate levels of aquaporin (AQP)-1, 2, 5 and 7 expression in the uteri of ovariectomized, sex-steroid deficient rats.

    abstract::In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2016.08.007

    authors: Chinigarzadeh A,Muniandy S,Salleh N

    更新日期:2016-11-01 00:00:00

  • 1alpha,25(OH)2 vitamin D3 actions on ion channels in osteoblasts.

    abstract::Membrane-initiated cellular responses to steroids include modulation of ion channel activities via signal transduction pathways. However, the molecular mechanisms involved in nongenomic actions remain only partially understood. Our research has focused on the rapid effects of 1alpha,25(OH)(2) Vitamin D(3) [1,25D] on L...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2005.09.012

    authors: Zanello LP,Norman A

    更新日期:2006-04-01 00:00:00

  • Effects of adrenal hormones on the expression of adiponectin and adiponectin receptors in adipose tissue, muscle and liver.

    abstract:BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2011.06.004

    authors: de Oliveira C,Iwanaga-Carvalho C,Mota JF,Oyama LM,Ribeiro EB,Oller do Nascimento CM

    更新日期:2011-11-01 00:00:00

  • 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one: a novel steroid from a soft coral Sinularia gibberosa.

    abstract::A novel steroid, 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one (gibberoketosterol) (1), along with four known steroids, was isolated from the lipophilic extracts of a Taiwanese soft coral Sinularia gibberosa. The structure of the new metabolite was determined on the basis of extensive spectral analyses and...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/s0039-128x(03)00036-9

    authors: Ahmed AF,Dai CF,Kuo YH,Sheu JH

    更新日期:2003-04-01 00:00:00

  • Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-tumor agents.

    abstract::Based on the fact that timosaponin A-III (TA-III) exhibits potent cytotoxic effects and has been considered as a potential anti-tumor agent, a range of novel sarsasapogenin derivatives 1, 2a-2g, 3, 4, 5, 6a-6g have been synthesized by a simple and facile synthetic route. The in vitro cytotoxic activity of these synthe...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2014.09.007

    authors: Yin Y,Zhao XC,Wang SJ,Gao PY,Li LZ,Ikejima T,Song SJ

    更新日期:2015-01-01 00:00:00

  • Studies on vitamin D metabolism: catabolism of 1 alpha, 25-dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 to a metabolite inactive on bone mineral mobilization.

    abstract::A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(80)90065-3

    authors: Ohnuma N,Kiyoki M,Bannai K,Naruchi T,Hashimoto Y,Noguchi T,Norman AW

    更新日期:1980-07-01 00:00:00

  • Biotransformation and molecular docking studies of aromatase inhibitors.

    abstract::Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2016.07.003

    authors: Martin GD,Narvaez J,Bulmer R,Durrant MC

    更新日期:2016-09-01 00:00:00

  • Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one.

    abstract::A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2020.108600

    authors: Wang J,Gu XZ,He LM,Li CC,Qiu WW

    更新日期:2020-05-01 00:00:00

  • Estrogen modulation of K(+) channel activity in hypothalamic neurons involved in the control of the reproductive axis.

    abstract::Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...

    journal_title:Steroids

    pub_type: 杂志文章,评审

    doi:10.1016/s0039-128x(01)00181-7

    authors: Kelly MJ,Rønnekleiv OK,Ibrahim N,Lagrange AH,Wagner EJ

    更新日期:2002-05-01 00:00:00

  • Steroidogenic activity of hACTH and related peptides on the human neocortex and fetal adrenal cortex in organ culture.

    abstract::Explants prepared from the neocortex and the fetal zone of the human fetal adrenal (gestational age 13 to 18weeks) were maintained under conditions of organ culture for 7 to 9 days during which time they were exposed to hACTH and various related peptides. Corticotrophic activity was monitored by the daily release of d...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(78)90037-5

    authors: Branchaud CT,Goodyer CG,Hall CS,Arato JS,Silman RE,Giroud CJ

    更新日期:1978-04-01 00:00:00

  • Cortisol metabolism and excretion in the isolated perfused rat kidney.

    abstract::The isolated perfused rat kidney allows a simultaneous kinetic study of both the renal metabolism and the urinary excretion of cortisol and its metabolites in the rat. In this system, cortisol was completely metabolized within 120 minutes. The main renal metabolites of cortisol (cortisone, 20 reduced cortisol and 20 r...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(77)90052-6

    authors: Reach G,Nakane H,Nakane Y,Auzan C,Corvol P

    更新日期:1977-11-01 00:00:00

  • Sterically crowded trialkylsilyl ether derivatives for the analysis of steroid metabolites.

    abstract::The applications of sterically crowed trialkyksilyl ether derivatives to the analysis and characterization by thin-layer chromatography, gas chromatography and mass spectrometry, of metabolites of 2alpha, 3alpha-cyclopropano-5alpha-androstan-17beta-ol in the rabbit are described. These derivatives are complementary to...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(77)90013-7

    authors: Quilliam MA,Templeton JF,Westmore JB

    更新日期:1977-05-01 00:00:00

  • 17-Hydroxyprogesterone metabolism in the monkey fetal adrenal: C17-20lyase and 21-hydroxylase activities.

    abstract::C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(81)90036-2

    authors: Sholl SA

    更新日期:1981-08-01 00:00:00

  • Enzyme immunoassay for cortisol in serum using cortisol 21-amine.

    abstract::Cortisol 21-amine (21-amino-11beta,17-dihydroxy-4-pregnene-3,20-dione) was prepared and an enzyme immunoassay for cortisol in serum was established using cortisol 21-amine conjugated with alkaline phosphatase. The minimal amount of cortisol detected was 1ng/tube and the measurable range was from 1 to 80 microgram/d1, ...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(78)90106-x

    authors: Kobayashi Y,Ogihara T,Amitani K,Watanabe F,Kiguchi T,Ninomiya I,Kumahara Y

    更新日期:1978-07-01 00:00:00

  • Isolation fo 15alpha-hydroxypregnenolone and 15alpha-hydroxydehydroisoandrosterone from human pregnancy urine.

    abstract::15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 mi...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/s0039-128x(78)80002-6

    authors: Stanczyk FZ,Stern M,Solomon S

    更新日期:1978-05-01 00:00:00

  • Metabolism of bile alcohols in the perfused rabbit liver - C26 bile alcohols.

    abstract::The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were foun...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(77)90099-x

    authors: Cohen BI,Kuramoto T,Rothschild MA,Graham R,Mosbach EH

    更新日期:1977-10-01 00:00:00

  • Synthesis and chemical reactions of the steroidal hormone 17α-methyltestosterone.

    abstract::Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen...

    journal_title:Steroids

    pub_type: 杂志文章,评审

    doi:10.1016/j.steroids.2015.11.004

    authors: El-Desoky el-SI,Reyad M,Afsah EM,Dawidar AA

    更新日期:2016-01-01 00:00:00

  • The corticosteroid metabolic profile of the mouse.

    abstract::Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2008.04.004

    authors: Shackleton CH,Hughes BA,Lavery GG,Walker EA,Stewart PM

    更新日期:2008-10-01 00:00:00

  • Carbon-13 nuclear magnetic resonance spectral data of steroidal vicinal ketols and related compounds.

    abstract::Carbon-13 nuclear magnetic resonance spectra for 31 3 beta-hydroxy and acetoxy androstane derivatives bearing vicinal oxygenated functions at ring D with and without oxygenated functions at C-6 are reported. Relative substituent effects are discussed. ...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(91)90077-9

    authors: Doller D,Gros EG

    更新日期:1991-04-01 00:00:00

  • Trilostane, an orally active inhibitor of steroid biosynthesis.

    abstract::Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to pregnenolone nor progesterone to corticoid hormones. When given orally to rats, trilostane inhibits corticosterone and aldo...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(78)90010-7

    authors: Potts GO,Creange JE,Hardomg HR,Schane HP

    更新日期:1978-09-01 00:00:00

  • Progestin metabolism in the rhesus monkey corpus luteum.

    abstract::For the purpose of describing the pathway by which estrones are synthesized in the rhesus monkey (Macaca mulatta) corpus luteum (CL), CL were obtained during the midluteal phase of the menstrual cycle and fragments incubated with equimolar amounts of [7-3H]pregnenolone plus [4-14C]progesterone. Metabolites including 3...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(80)90019-7

    authors: Sholl SA,Wolf RC

    更新日期:1980-08-01 00:00:00

  • 1H and 13C NMR characteristics of synthetic derivatives of steroid sapogenins. Part III. 16Beta,23:23,26-diepoxy side chains.

    abstract::The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2008.01.027

    authors: Vázquez-Ramírez I,Macías-Alonso M,Arcos-Ramos RO,Ruíz-Pérez KM,Solano-Ramírez DO,Iglesias Arteaga MA

    更新日期:2008-07-01 00:00:00

  • Metabolism of diethylstilbestrol in the C3H mouse: chromatographic systems for the quantitative analysis of DES metabolic products.

    abstract::Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(78)90029-6

    authors: Helton ED,Gough BJ,King JW Jr,Thenot JP,Horning EC

    更新日期:1978-04-01 00:00:00

  • A helminth cestode parasite express an estrogen-binding protein resembling a classic nuclear estrogen receptor.

    abstract::The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2011.05.003

    authors: Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

    更新日期:2011-09-01 00:00:00

  • Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3 beta-hydroxysteroid dehydrogenase.

    abstract::The biosynthesis of progesterone from [3H]pregnenolone was curvilinear over a 6 h time course in human placenta cytotrophoblasts and in human placenta choriocarcinoma cells (JEG-3 cells). Mass measurements determined independently by radioimmunoassay indicate that the progesterone synthesized by cytotrophoblasts (21.0...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/0039-128x(88)90043-8

    authors: Sharp RB,Penning TM

    更新日期:1988-05-01 00:00:00

  • Digitalis-like compounds: synthesis and biological evaluation of seco-D and D-homo derivatives.

    abstract::The synthesis of seco-D and D-homo digitalis derivatives, from the carda-14,20(22)-dienolide 1, is described. Selective ozonolysis gave the seco-D 14-ketoaldehyde 2a. Modification of the two carbonyl groups and of the alpha, beta-unsaturated lactone ring of the seco-D 14-ketoaldehyde 2a allowed preparation of derivati...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/s0039-128x(96)00117-1

    authors: Gobbini M,Benicchio A,Marazzi G,Padoani G,Torri M,Melloni P

    更新日期:1996-10-01 00:00:00

  • Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: protective effect of 17 beta-estradiol.

    abstract::Oxidative stress is thought to play a crucial role in the pathogenesis of chronic diabetic complications. We investigated the protective effects of 17 beta-estradiol (E2) on alloxan-induced stress oxidant, hepatic dysfunction and histological changes in male rats liver and pancreas. Our results showed that 17 beta-est...

    journal_title:Steroids

    pub_type: 杂志文章

    doi:10.1016/j.steroids.2007.12.026

    authors: Hamden K,Carreau S,Boujbiha MA,Lajmi S,Aloulou D,Kchaou D,Elfeki A

    更新日期:2008-05-01 00:00:00