Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog.

abstract：:This study examines the distribution of 5 alpha-reductase and 3 alpha(beta)-hydroxysteroid dehydrogenase activities throughout the intact hyperplastic prostate gland and relate these measurements to the fibromuscular/epithelial composition and to the gross glandular morphology. The relative capacities of the stroma an...

journal_title：Steroids

authors： Habib FK,Beynon L,Chisholm GD,Busuttil A

更新日期：1983-01-01 00:00:00

abstract：:The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the s...

journal_title：Steroids

authors： Bartke A,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:Some properties of immunoreactive estradiol secreted by adrenals and ovaries of immature female rats were studied. It was shown that adrenals and ovaries of 15-day-old animals secrete approximately equal amounts of immunoreactive estradiol, with thin-layer chromatogram of immunoreactive material being identical for bo...

journal_title：Steroids

authors： Tinnikov AA,Bazhan NM,Yakovleva TV

更新日期：1992-04-01 00:00:00

abstract：:The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...

journal_title：Steroids

authors： Zomer G,Stavenuiter JF

更新日期：1990-10-01 00:00:00

abstract：:This study examined the role of protein kinase C enzymatic activity as a physiologic determinant of stromal cell death in decidua basalis (DB) during pregnancy. The expression of epidermal growth factor receptor (EGF-R) and Bcl2 was used as an indicator of stromal cell proliferation/survival, whereas Bax and the occur...

journal_title：Steroids

authors： Ogle TF,Dai D,George P

更新日期：1999-09-01 00:00:00

abstract：:16alpha-hydroxydehydroepiandrosterone was for the first time detected in human seminal plasma by using a combination of extraction, solvent partition, HPLC separation and final quantification by GC-MS as pentafluorobenzyloxime trimethylsilyl ether derivative in SIM mode. Three effective mass fragments m/z 266, 356 and...

journal_title：Steroids

authors： Hert J,Hill M,Hampl R

更新日期：2004-10-01 00:00:00

abstract：:Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...

journal_title：Steroids

authors： Li H,Xie H,Fu M,Li W,Guo B,Ding Y,Wang Q

更新日期：2013-02-01 00:00:00

abstract：:A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic keto...

journal_title：Steroids

authors： Barthakur MG,Hasib A,Gogoi J,Boruah RC

更新日期：2010-06-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...

journal_title：Steroids

authors： Choi YS,Yang HI,Cho S,Jung JA,Jeon YE,Kim HY,Seo SK,Lee BS

更新日期：2012-11-01 00:00:00

abstract：:There is considerable evidence that although estradiol may trigger the preovulatory surge of gonadotropins, progesterone is required for its full magnitude and duration and that glucocorticoids bring about selective follicle-stimulating hormone release. The luteinizing hormone-releasing hormone (LHRH) neuron does not ...

journal_title：Steroids

authors： Mahesh VB,Brann DW

更新日期：1998-05-01 00:00:00

abstract：:Fourteen esters (formate, acetate, propionate, butyrate, hexanoate, heptanoate, and benzoate) located at C-11 of 11 beta-hydroxyesterone and 11 beta-hydroxyestradiol-17 beta were synthesized and evaluated for uterotropic and gonadotropin release inhibition in rats, as well as their ability to displace (3H) estradiol-1...

journal_title：Steroids

authors： Segaloff A,Gabbard RB

更新日期：1984-01-01 00:00:00

abstract：:Anabolic androgenic steroids (AAS) are testosterone and testosterone-derivative compounds sporadically employed by athletes and increasingly used recreationally to acquire a competitive edge or improve body composition. Nevertheless, users are subject to undesired side effects majorly associated with tissue-specific a...

journal_title：Steroids

authors： Machek SB,Cardaci TD,Wilburn DT,Willoughby DS

更新日期：2020-12-01 00:00:00

abstract：:Human keratinocytes convert 25(OH)D(3) to hormonally active 1alpha,25(OH)(2)D(3) and respond to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1alpha,25(OH)(2)D(3) are short-lived. 1alpha,25(OH)(2)D(3) induces 24-hydroxylase (CYP24) that rapidly metabolizes the hormone, yi...

journal_title：Steroids

authors： Schuster I,Egger H,Bikle D,Herzig G,Reddy GS,Stuetz A,Stuetz P,Vorisek G

更新日期：2001-03-01 00:00:00

abstract：:7 beta-Methyl-chenodeoxycholic acid (7-MeCDC, 3 alpha, 7 alpha-dihydroxy-7 beta-methyl-5 beta-cholan-24-oic acid), 7 alpha-methyl-ursodeoxycholic acid (7-MeUDC, 3 alpha, 7 beta-dihydroxy-7 alpha-methyl-5 beta-cholan-24-oic acid), 7 xi-methyl-lithocholic acid (7-MeLC, 3 alpha-hydroxy-7 xi-methyl-5 beta-cholan-24-oic ac...

journal_title：Steroids

authors： Hylemon PB,Moody DP,Cohen BI,Une M,Mosbach EH

更新日期：1984-10-01 00:00:00

abstract：:The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and...

journal_title：Steroids

authors： Broess AI,van Vliet NP,Groen MB,Hamersma H

更新日期：1992-11-01 00:00:00

abstract：:Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...

journal_title：Steroids

authors： Sweet F

更新日期：1981-02-01 00:00:00

abstract：:The isoflavonoids, genistein (4',5,7-trihydroxyisoflavone), biochanin A (5,7-dihydroxy-4'-methoxyisoflavone), daidzein (4',7-dihydroxyisoflavone), and formononetin (7-hydroxy-4'-methoxyisoflavone) are supposed to be health-promoting dietary factors of plant origin. They are particularly abundant in seeds and other par...

journal_title：Steroids

authors： Lapcík O,Hill M,Hampl R,Wähälä K,Adlercreutz H

更新日期：1998-01-01 00:00:00

abstract：:A sensitive accurate assay for the placental microsomal 3 beta-hydroxysteroid dehydrogenase (E.C.1.1.1.51) has been developed using tritiated substrates. Kinetic analysis of the enzyme with 3 beta-hydroxy-5-androsten-17-one and 3 beta-hydroxy-5-pregnen-20-one indicates that the apparent Km values for these substrates ...

journal_title：Steroids

authors： Gibb W

更新日期：1979-04-01 00:00:00

abstract：:The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection o...

journal_title：Steroids

authors： Bain JD,Kasman LH,Bercovitz AB,Lasley BL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder due to mutation in the CYP21A2 gene. OBJECTIVE:To elucidate the genetic basis of 21-hydroxylase-deficient CAH in Hong Kong Chinese patients. PATIENTS AND METHODS:Mutational analysis of the CY...

journal_title：Steroids

authors： Chan AO,But WM,Ng KL,Wong LM,Lam YY,Tiu SC,Lee KF,Lee CY,Loung PY,Berry IR,Brown R,Charlton R,Cheng CW,Ho YC,Tse WY,Shek CC

更新日期：2011-09-01 00:00:00

abstract：:Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depres...

journal_title：Steroids

authors： Bai Y,Song L,Dai G,Xu M,Zhu L,Zhang W,Jing W,Ju W

更新日期：2018-07-01 00:00:00

abstract：:Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...

journal_title：Steroids

authors： Templeton JF,Majgier-Baranowska H,Marat K

更新日期：2000-04-01 00:00:00

abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...

journal_title：Steroids

authors： Zheng QC,Chen GD,Kong MZ,Li GQ,Cui JY,Li XX,Wu ZY,Guo LD,Cen YZ,Zheng YZ,Gao H

更新日期：2013-09-01 00:00:00

abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...

journal_title：Steroids

authors： Shutt DA,Shearman RP,Lyneham RC,Clarke AH,McMahon GR,Goh P

更新日期：1975-09-01 00:00:00

abstract：:Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2)...

journal_title：Steroids

authors： Kornel L,Miyabo S

更新日期：1975-06-01 00:00:00

abstract：:Male rabbits were infused at a constant rate with 3H-androstenedione/14C-estrone (n = 5) or 3H-testosterone/14C-estradiol-17 beta (n = 3) for 3 1/2 hr and blood samples were obtained over the last hour and analyzed for radioactivity as androstenedione (A), testosterone (T), estrone (E1), estradiol-17 beta (E2 beta) an...

journal_title：Steroids

authors： Bourget C,Flood C,Longcope C

更新日期：1984-02-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...

journal_title：Steroids

authors： Gocek E,Kiełbiński M,Wyłób P,Kutner A,Marcinkowska E

更新日期：2008-12-22 00:00:00

abstract：:The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...

journal_title：Steroids

authors： Economou EV,Livaniou E,Evangelatos GP,Ithakissios DS

更新日期：1992-01-01 00:00:00

abstract：:Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects...

journal_title：Steroids

authors： Tsai CC,Tey SL,Chang LC,Su YT,Lin KJ,Huang SC

更新日期：2018-08-01 00:00:00

abstract：:Fast atom bombardment/mass spectrometry or liquid secondary ion mass spectrometry provides the capability for direct analysis of steroid conjugates (sulfates, glucuronides) without prior hydrolysis or derivatization. During the analysis of biologic extracts, limitations on the sensitivity of detection arise from the p...

journal_title：Steroids

authors： Gaskell SJ

更新日期：1990-10-01 00:00:00