In vivo androgen retention in mouse kidney.

abstract：:CGS 16949A inhibited the conversion of [4-14C]androstenedione (A) to [4-14C]estrone by human placental microsomes in a competitive manner (Ki = 1.6 nM). Aminoglutethimide, also a competitive inhibitor, had a Ki = 0.7 microM in this assay system. The Km for the aromatization of A was 0.11 microM. Using ovarian microsom...

journal_title：Steroids

authors： Steele RE,Mellor LB,Sawyer WK,Wasvary JM,Browne LJ

更新日期：1987-07-01 00:00:00

abstract：:Four new pregnane glycosides, stelmatocryptonoside A, B, C, and D (1-4), were isolated from the stems of Stelmatocrypton khasianum. On the basis of chemical and spectral data, the structures of 1-4 were established as 3beta, 16alpha-dihydroxy-pregn-5-en-20-one-16-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-...

journal_title：Steroids

authors： Zhang Q,Zhao Y,Wang B,Feng R,Liu X,Cheng T

更新日期：2002-04-01 00:00:00

abstract：:The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...

journal_title：Steroids

authors： Alvarez M,Jover A,Carrazana J,Meijide F,Soto VH,Tato JV

更新日期：2007-06-01 00:00:00

abstract：:Circadian rhythms in physiology and behavior are known to be influenced by the estrous cycle in female rodents. The clock genes responsible for the generation of circadian oscillations are widely expressed both within the central nervous system and peripheral tissues, including those that comprise the reproductive sys...

journal_title：Steroids

authors： Nakamura TJ,Sellix MT,Kudo T,Nakao N,Yoshimura T,Ebihara S,Colwell CS,Block GD

更新日期：2010-03-01 00:00:00

abstract：:We have investigated the metabolism of deoxycorticosterone in A6 cells, a continuous cell line derived from the kidney of Xenopus laevis. A6 cells at confluence were incubated with serum-free culture media containing 2.5 microM [3H] deoxycorticosterone. When radioactive compounds in incubation media were separated by ...

journal_title：Steroids

authors： Matsuzaki K,Arai T,Miyazaki T,Yasuda K

更新日期：1995-07-01 00:00:00

abstract：:Glucocorticoids are important regulators of metabolism and immune function. Synthetic glucocorticoids are extensively used for immunosuppression/anti-inflammatory therapy. Since the glucocorticoid receptor (GR) is central to most hormone effects; its in vivo regulation will influence hormone/drug action. An alternativ...

journal_title：Steroids

authors： DuBois DC,Sukumaran S,Jusko WJ,Almon RR

更新日期：2013-02-01 00:00:00

abstract：:Biotransformation of an orally active contraceptive drug, desogestrel (1), with Cunninghamella elegans yielded a new metabolite, 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3,6-dione (2), along with five known metabolites, i.e., 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3β,6β,17β-triol...

journal_title：Steroids

authors： Ibrahim I,Atia-Tul-Wahab,Khan N,Siddiqui M,Hassan Ajandouz E,Jabeen A,Mesmar J,Baydoun E,Iqbal Choudhary M

更新日期：2020-10-01 00:00:00

abstract：:During the periparturient period, dairy cows are subjected to physiological changes that may induce immunosuppression and an increased susceptibility of the animal to bacterial infections such as mastitis. The incidence of clinical environmental mastitis is high during the last period of gestation, at parturition and ...

journal_title：Steroids

authors： Winters KR,Meyer E,Van Merris VM,Van Den Broeck WL,Duchateau L,Burvenich C

更新日期：2003-05-01 00:00:00

abstract：:Anabolic androgenic steroids (AAS) are testosterone and testosterone-derivative compounds sporadically employed by athletes and increasingly used recreationally to acquire a competitive edge or improve body composition. Nevertheless, users are subject to undesired side effects majorly associated with tissue-specific a...

journal_title：Steroids

authors： Machek SB,Cardaci TD,Wilburn DT,Willoughby DS

更新日期：2020-12-01 00:00:00

abstract：:Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P (GP) reagent to give GP hydrazones. Steroid GP hydrazones contain a quaternary nitrogen atom and are readily ...

journal_title：Steroids

authors： Khan MA,Wang Y,Heidelberger S,Alvelius G,Liu S,Sjövall J,Griffiths WJ

更新日期：2006-01-01 00:00:00

abstract：:Cortisol 21-amine (21-amino-11beta,17-dihydroxy-4-pregnene-3,20-dione) was prepared and an enzyme immunoassay for cortisol in serum was established using cortisol 21-amine conjugated with alkaline phosphatase. The minimal amount of cortisol detected was 1ng/tube and the measurable range was from 1 to 80 microgram/d1, ...

journal_title：Steroids

authors： Kobayashi Y,Ogihara T,Amitani K,Watanabe F,Kiguchi T,Ninomiya I,Kumahara Y

更新日期：1978-07-01 00:00:00

abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...

journal_title：Steroids

authors： McGinley R,Casey JH

更新日期：1979-02-01 00:00:00

abstract：:The accurate analysis of trace components in complex biological matrices requires the use of reliable internal standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled analogues of the analyte molecules are the most appropriate internal standards. In this paper the synthesis of the 3...

journal_title：Steroids

authors： Mitamura K,Mabuchi T,Nagae K,Nakajima M,Matsumoto R,Fujioka S,Sato K,Satoh née Okihara R,Iida T,Ogawa S,Hofmann AF,Ikegawa S

更新日期：2012-11-01 00:00:00

abstract：:The relationship between 14CO2 evolution from the catabolism of [26 or 2714C] cholesterol to bile acids was studied in rats with biliary fistulae. When equal quantities of [26 or 2714C] cholesterol and [414C] cholesterol were administered, there was a significant linear relationship between 14CO2 expiration in the bre...

journal_title：Steroids

authors： Davis RA,Showalter P,Kern F Jr

更新日期：1975-10-01 00:00:00

abstract：:Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...

journal_title：Steroids

authors： Boulch NL,Cancela L,Miravet L

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Urinary steroid profiling by GC or GC-MS are established clinical tools to complement other biochemical tests in the diagnosis and investigation of a wide range of adrenocortical disorders, but normative data on adults using the more specific GC-MS are lacking. Our objective was to set up the reference inter...

journal_title：Steroids

authors： Chan AO,Taylor NF,Tiu SC,Shek CC

更新日期：2008-09-01 00:00:00

abstract：:A technique of incubation of testicular tissue in vitro with radiolabeled precursors was applied in the investigation of the steroid biosynthesis by testes of four young men after long-term, high-dose estrogen treatment. A positive correlation between plasma and testicular steroid levels, and in vitro capacity of the ...

journal_title：Steroids

authors： Rodriguez-Rigau LJ,Tcholakian RK,Smith KD,Steinberger E

更新日期：1977-06-01 00:00:00

abstract：:The LNCaP-Fast Growing Colony (FGC) human prostate cancer cell line proliferates in response to the addition of dihydrotestosterone (DHT) 10(-10)-10(-8) M in charcoal-stripped serum-supplemented media. LNCaP-FGC cells will not attach or proliferate in serum-free conditions. LNCaP-FGC stock cultures were maintained in ...

journal_title：Steroids

authors： Kirschenbaum A,Ren M,Levine AC

更新日期：1993-09-01 00:00:00

abstract：:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...

journal_title：Steroids

authors： Wang C,Zhao M,Yang J,Peng S

更新日期：2001-11-01 00:00:00

abstract：:A number of testosterone analogs with a 13,14-secosteroidal fragment have been prepared from (13S)-13-iodo-6beta-methoxy-3alpha, 5-cyclo-13,14-seco-5alpha-androstan-14,17-dione. The key steps involved stereoselective deiodination of the starting compound with triphenylphosphine and selective protection of the 17-keto ...

journal_title：Steroids

authors： Khripach VA,Zhabinskii VN,Kuchto AI,Zhiburtovich YY,Fando GP,Lyakhov AS,Govorova AA,Groen MB,van der Louw J,de Groot A

更新日期：2004-07-01 00:00:00

abstract：:Determinations of oxygen solubility in serum were made utilizing various concentrations of corticosteroids in the serum. Within a certain concentration range dexamethasone and betamethasone caused an increase in oxygen solubility. None of the other steroids tested demonstrated this property. ...

journal_title：Steroids

authors： Gainer JL,Kelly R

更新日期：1976-09-01 00:00:00

abstract：:Aldosterone induces fibrotic changes in cardiovascular tissues but its effects have usually been demonstrated in models of pre-existing renal injury and/or hypertension. This study tests the hypothesis that aldosterone can directly induce vascular fibrotic changes in the absence of prior renal injury or hypertension. ...

journal_title：Steroids

authors： Brem AS,Morris DJ,Li X,Ge Y,Shaw S,Gong R

更新日期：2013-03-01 00:00:00

abstract：:A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...

journal_title：Steroids

authors： Coufalová L,Mrózek L,Rárová L,Plaček L,Opatřilová R,Dohnal J,Král'ová K,Paleta O,Král V,Drašar P,Jampílek J

更新日期：2013-05-01 00:00:00

abstract：:The abilities of a variety of estrogens and antiestrogens to stimulate DNA synthesis in the prepuberal rat uterus were compared. One microgram of each compound was administered in vivo via a single intraperitoneal injection. DNA synthesis was assayed in vitro in isolated nuclei 24 h later. The relative mitogenicities ...

journal_title：Steroids

authors： Stack G,Korach K,Gorski J

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligand but whether this steroid can support osteoblast maturation has not be...

journal_title：Steroids

authors： Mansell JP,Shorez D,Farrar D,Nowghani M

更新日期：2009-11-01 00:00:00

abstract：:Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...

journal_title：Steroids

authors： Leng T,Liu A,Wang Y,Chen X,Zhou S,Li Q,Zhu W,Zhou Y,Su X,Huang Y,Yin W,Qiu P,Hu H,Xiong ZG,Zhang J,Yan G

更新日期：2016-01-01 00:00:00

abstract：:Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...

journal_title：Steroids

authors： Hanekamp EE,Gielen SC,van Oosterhoud SA,Burger CW,Grootegoed JA,Huikeshoven FJ,Blok LJ

更新日期：2003-11-01 00:00:00

abstract：:We have previously demonstrated that 1α,25 dihydroxy-vitamin D(3) (1α,25(OH)(2)D(3)) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR). In this work, we have investigated whether 1α,25(OH)(2)D(3) exerts its growth i...

journal_title：Steroids

authors： Gonzalez-Pardo V,D'Elia N,Verstuyf A,Boland R,Russo de Boland A

更新日期：2012-09-01 00:00:00

abstract：:The reaction of 23-oxotigogenin acetate with TMSOTf in THF afforded the corresponding bisnorcholanic lactone in 60% yield. The analogous reactions carried out in dichloromethane or benzene gave the rearranged products--the isomeric spirostanic ketone (10-15%) and bisfuran (40-42%). Similar products were also obtained ...

journal_title：Steroids

authors： Jastrzebska I,Siergiejczyk L,Tomkiel AM,Urbańczyk-Lipkowska Z,Wójcik D,Morzycki JW

更新日期：2009-08-01 00:00:00

abstract：:The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...

journal_title：Steroids

authors： Solaja BA,Dermanović M,Lim DM,Paik YK,Tinant B,Declerq JP

更新日期：1997-11-01 00:00:00