Abstract:
:The reaction of 23-oxotigogenin acetate with TMSOTf in THF afforded the corresponding bisnorcholanic lactone in 60% yield. The analogous reactions carried out in dichloromethane or benzene gave the rearranged products--the isomeric spirostanic ketone (10-15%) and bisfuran (40-42%). Similar products were also obtained upon treatment of 23,24-epoxysapogenins with BF(3). The epoxides treated with TiCl(4) afforded mostly chlorohydrins and no rearranged products were detected.
journal_name
Steroidsjournal_title
Steroidsauthors
Jastrzebska I,Siergiejczyk L,Tomkiel AM,Urbańczyk-Lipkowska Z,Wójcik D,Morzycki JWdoi
10.1016/j.steroids.2009.02.010subject
Has Abstractpub_date
2009-08-01 00:00:00pages
675-83issue
8eissn
0039-128Xissn
1878-5867pii
S0039-128X(09)00060-9journal_volume
74pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Homogenates from human myometrium with an added NADPH regenerating system and ATP were incubated with 4-(14)C progesterone. Six metabolites were identified: 5alpha-pregnane-3, 20-dione, 5beta-pregnane-3, 20-dione, 3alpha-hydroxy-4-pregnen-20-one, 3beta hydroxy-4-pregnen-20-one. 20alpha-hydroxy-4-pregnen-3-one and 20be...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90131-3
更新日期:1977-07-01 00:00:00
abstract::Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational st...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.011
更新日期:2014-09-01 00:00:00
abstract::Key to the production of biologically active steroids is the enzyme 3 beta-hydroxysteroid dehydrogenase-isomerase. Some controversy has arisen concerning the subcellular distribution of this enzyme within steroidogenic cells. The distribution of 3 beta-hydroxysteroid dehydrogenase-isomerase was assessed in subcellular...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90056-2
更新日期:1991-06-01 00:00:00
abstract::Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and mitochondrial activity were evaluated on 158N murine oligodendrocytes, C6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.01.005
更新日期:2015-07-01 00:00:00
abstract::A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 wa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.09.002
更新日期:2016-11-01 00:00:00
abstract::The bile flow and the bile acid secretion, calculated on liver weight basis, increased 12 H and 24 H after 60-70% hepatectomy and returned to the initial levels thereafter. The biliary phospholipid secretion much more increased than bile acids, but the cholesterol secretion decreased. Bile acid composition changed wit...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90071-6
更新日期:1985-03-01 00:00:00
abstract::Androgen-binding protein/sex hormone-binding globulin (ABP/SHBG) is an extracellular carrier protein that binds androgens and estrogens with high affinity. In the adult, ABP/SHBG is thought to function in the male reproductive system and the general circulation in both sexes to modulate the actions of sex steroids. Th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00049-9
更新日期:1996-07-01 00:00:00
abstract::We assayed Type 1 (high K+) and Type 2 (high Na+) human breast cyst fluids for DHEA-S. When an antibody specific for the 3-sulfoconjugate end of DHEA-S was used, Type 1 cyst fluids (n = 18) showed a content of 114 +/- 68 micrograms/mL (mean +/- sigma) and Type 2 cyst fluids (n = 14) of 35 +/- 17 micrograms/mL (P less ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(88)90004-9
更新日期:1988-09-01 00:00:00
abstract::A virulent culture of Hymenoscyphus fraxineus, the causal agent of ash dieback, was investigated for its production of secondary metabolites in a 70 L batch fermentation. Chemical analysis of the mycelial extract by means of flash chromatography and preparative HPLC led to the isolation of a new ergostane-type steroid...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.03.007
更新日期:2018-07-01 00:00:00
abstract::A sensitive accurate assay for the placental microsomal 3 beta-hydroxysteroid dehydrogenase (E.C.1.1.1.51) has been developed using tritiated substrates. Kinetic analysis of the enzyme with 3 beta-hydroxy-5-androsten-17-one and 3 beta-hydroxy-5-pregnen-20-one indicates that the apparent Km values for these substrates ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90018-7
更新日期:1979-04-01 00:00:00
abstract::This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.12.011
更新日期:2008-04-01 00:00:00
abstract::Removal of free calcium ions from the incubation medium of isolated bovine adrenocortical cells with EGTA reduced basal cortisol synthesis and blocked the effects of ACTH; additional calcium restored normal steroid synthesis. Calcium channel blockers, verapamil and nitrendipine and the calmodulin antagonist, trifluope...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90019-4
更新日期:1985-06-01 00:00:00
abstract::A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.02.001
更新日期:2013-05-01 00:00:00
abstract::11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR). This receptor has an equal affinity for the glucocorti...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00024-7
更新日期:1995-01-01 00:00:00
abstract::Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P (GP) reagent to give GP hydrazones. Steroid GP hydrazones contain a quaternary nitrogen atom and are readily ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.08.002
更新日期:2006-01-01 00:00:00
abstract::Effective syntheses of endo- and exocyclic alpha,beta-unsaturated ketones as CC dipolarophiles were carried out in the 13alpha-estrone series. The 1,3-dipolar cycloadditions of 15,16alpha,beta-unsaturated ketones of 13alpha-estrone 3-methyl and 3-benzyl ether with nitrilimines stereoselectively furnished two regioisom...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.02.001
更新日期:2009-06-01 00:00:00
abstract::Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.06.005
更新日期:2015-09-01 00:00:00
abstract::Carbon-11-labeled casimiroin analogues were first designed and synthesized as new potential PET agents for imaging of quinone reductase (QR) 2 and aromatase expression in breast cancer. [(11)C]casimiroin (6-[(11)C]methoxy-9-methyl-[1,3]dioxolo[4,5-h]quinolin-8(9H)-one, [(11)C]11) and its carbon-11-labeled analogues 5,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.004
更新日期:2010-12-01 00:00:00
abstract::We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.05.009
更新日期:2011-09-01 00:00:00
abstract::4- to 8-cell mouse PIE's (preimplantation embryos) were cultured in vitro for 48 hr in media containing various concentrations of the anti-estrogen CI-628. Graded effects of the various concentrations were observed with the highest concentration (1.5 microng/ml) being 100% effective in blocking development to the blas...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90005-8
更新日期:1977-03-01 00:00:00
abstract::Synthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expa...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.10.005
更新日期:2018-12-01 00:00:00
abstract::Exposure of immature rat ovaries to pregnant mare's serum gonadotropin (PMS) results in a prompt increase in testosterone and progesterone output but synthesis of estradiol (E2) increases only after a lag period of several hours. Actinomycin D (Act-D) given with PMS did not inhibit testosterone or progesterone product...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90004-6
更新日期:1977-03-01 00:00:00
abstract::A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic keto...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.02.009
更新日期:2010-06-01 00:00:00
abstract::Circulation levels of estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHAS) have been measured in plasma using a radioimmunoassay for estrone and dehydroepiandrosterone following extraction and hydrolysis of the sulfate. The mean +/- SE concentrations of E1S and DHAS in normal men were 458 +/- 25 pg/ml and 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(79)80017-3
更新日期:1979-11-01 00:00:00
abstract::We have investigated the metabolism of deoxycorticosterone in A6 cells, a continuous cell line derived from the kidney of Xenopus laevis. A6 cells at confluence were incubated with serum-free culture media containing 2.5 microM [3H] deoxycorticosterone. When radioactive compounds in incubation media were separated by ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00038-r
更新日期:1995-07-01 00:00:00
abstract::The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.03.007
更新日期:2007-06-01 00:00:00
abstract::Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2010.06.012
更新日期:2010-12-01 00:00:00
abstract::Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. The influence of steroids on inflammatory processes has long been established since glucocorticoids and their receptor belong to the regulatory network involved in inhibition of several inflamma...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2006.10.007
更新日期:2007-01-01 00:00:00
abstract::An efficient procedure for the chemical synthesis of 3 beta-hydroxy-5 alpha-cholest-8-en-7-one and 3 beta-hydroxy-5 alpha-cholest-8-en-11-one is described. These ketosterols have been shown to have possible significant hypocholesterolemic effects when fed to normal rats at a level of 0.15% in a laboratory chow diet. T...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(86)90027-9
更新日期:1986-11-01 00:00:00
abstract::The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior b...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.11.003
更新日期:2008-02-01 00:00:00