Synthesis and analgesic effects of kyotorphin-steroid linkers.

Abstract:

:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher than that of KTP and the mixture of KTP and hydrocortisone or estrone in the CNS and/or the periphery administration.

journal_name

Steroids

journal_title

Steroids

authors

Wang C,Zhao M,Yang J,Peng S

doi

10.1016/s0039-128x(01)00112-x

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

811-5

issue

11

eissn

0039-128X

issn

1878-5867

pii

S0039-128X(01)00112-X

journal_volume

66

pub_type

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