Abstract:
:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher than that of KTP and the mixture of KTP and hydrocortisone or estrone in the CNS and/or the periphery administration.
journal_name
Steroidsjournal_title
Steroidsauthors
Wang C,Zhao M,Yang J,Peng Sdoi
10.1016/s0039-128x(01)00112-xsubject
Has Abstractpub_date
2001-11-01 00:00:00pages
811-5issue
11eissn
0039-128Xissn
1878-5867pii
S0039-128X(01)00112-Xjournal_volume
66pub_type
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