Abstract:
:Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to pregnenolone nor progesterone to corticoid hormones. When given orally to rats, trilostane inhibits corticosterone and aldosterone production and elevates circulating levels of pregnenolone at doses lower than those that produce adrenal hypertrophy or inhibit gonadal steroidogenesis.
journal_name
Steroidsjournal_title
Steroidsauthors
Potts GO,Creange JE,Hardomg HR,Schane HPdoi
10.1016/0039-128x(78)90010-7subject
Has Abstractpub_date
1978-09-01 00:00:00pages
257-67issue
2eissn
0039-128Xissn
1878-5867pii
0039-128X(78)90010-7journal_volume
32pub_type
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