Androstenedione and testosterone biosynthesis by the adrenal cortex of the horse.

abstract：:The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testosterone-3-(carboxymethyl) oxime-peroxidase by the mixed anhydride method was found to give a conjugate of high ...

journal_title：Steroids

authors： Rajkowski KM,Cittanova N,Desfosses B,Jayle MF

更新日期：1977-05-01 00:00:00

abstract：:Allopregnanolone (3α-THP) is one of the main reduced progesterone (P4) metabolites that is recognized as a neuroprotective and myelinating agent. 3α-THP also induces proliferation of different neural cells. It has been shown that P4 favors the progression of glioblastomas (GBM), the most common and aggressive primary ...

journal_title：Steroids

authors： Zamora-Sánchez CJ,Hansberg-Pastor V,Salido-Guadarrama I,Rodríguez-Dorantes M,Camacho-Arroyo I

更新日期：2017-03-01 00:00:00

abstract：:Estradiol-17 beta labeled with deuterium in the positions 2 or 4 can be prepared from 2-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol 3-methyl ether 17-acetate or 4-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol, respectively, in refluxing CH3COO(2)H/(2)H2O. The same reaction performed on 4-acetoxymercurio-...

journal_title：Steroids

authors： Ferraboschi P,Ravasi M,Santaniello E

更新日期：1983-06-01 00:00:00

abstract：:In this paper we report the synthesis of four fluorinated analogues of brassinosteroids in which fluorine was introduced stereoselectively at C-2. The bioactivity of these new compounds was evaluated using the rice lamina inclination test. The results show that two of these analogues elicit high bioactivity, suggestin...

journal_title：Steroids

authors： Acebedo SL,Ramírez JA,Galagovsky LR

更新日期：2009-04-01 00:00:00

abstract：:In an attempt to justify use of trypsin to achieve more thorough dispersion of luteal cell clumps in vitro, progesterone (P) production by collagenase dispersed monkey luteal cells from the mid-luteal phase corpus luteum (CL) was examined in vitro either after 10 min, or continuous (3h) exposure to trypsin (TR). In th...

journal_title：Steroids

authors： Gulyas BJ,Yuan LC,Hodgen GD

更新日期：1980-01-01 00:00:00

abstract：:An enzyme immunoassay for estrone in swine serum was established. For this, beta-galactosidase from E. coli was conjugated through estrone-17 (O-carboxymethyl)oxime using a mixed anhydride reaction. The percentage of immunoreactive estrone-17 (O-carboxymethyl)oxime-beta-galactosidase conjugate was estimated to be abou...

journal_title：Steroids

authors： Tamamura F,Nakao T,Tsunoda N,Kawata K

更新日期：1982-06-01 00:00:00

abstract：:Dioscorea panthaica is a traditional Chinese medicinal herb used in the treatment of various physiological conditions, including cardiovascular disease, gastropathy and hypertension. Steroidal saponins (SS) are the main active ingredients of this herb and have effects on myocardial ischemia and cancer. The phytochemic...

journal_title：Steroids

authors： Wang W,Zhao Y,Jing W,Zhang J,Xiao H,Zha Q,Liu A

更新日期：2015-03-01 00:00:00

abstract：:We report the synthesis of 3 beta,15 beta,17 alpha-trihydroxy-5-pregnen-20- one (1) from 3 beta,15 beta-dihydroxy-5,16-pregnadien-20-one (11) in 7 steps using boronate derivatives as a means of protecting the 17,20-glycol side-chain of steroid intermediates. 16 alpha,17 alpha-Epoxy-3 beta,15 beta-dihydroxy-5- pregnen-...

journal_title：Steroids

authors： Joannou GE,Reeder AY

更新日期：1996-01-01 00:00:00

abstract：:Glucocorticoids are well-recognized modulators of immunocytes and osteoblasts via specific receptor-mediated mechanisms. We have evaluated the in vitro effect of interleukin 2 (IL-2) on the expression of glucocorticoid receptors (GRs) in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors and osteo...

journal_title：Steroids

authors： Sartori ML,Masera RG,Staurenghi A,Racca S,Angeli A

更新日期：1998-05-01 00:00:00

abstract：:Complete analysis of the proton nuclear magnetic resonance spectrum of desoxycorticosterone (DOC) has been made using selective double irradiation, two-dimensional experiments, relaxation rate, and nuclear Overhauser effect measurements in order to specify the structure and conformation of products encountered during ...

journal_title：Steroids

authors： Kouadio L,Bernard P,Sabot JF,Petit-Ramel MM,Barbier CM,Pinatel HJ

更新日期：1988-03-01 00:00:00

abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...

journal_title：Steroids

authors： Shutt DA,Shearman RP,Lyneham RC,Clarke AH,McMahon GR,Goh P

更新日期：1975-09-01 00:00:00

abstract：:The ring A monoglucuronides and monosulfates of 2-hydroxyestriol were synthesized from 2-hydroxyestriol 16,17-diacetate by means of the Koenigs-Knorr reaction with methyl alpha-acetobromoglucuronate and sulfation with sulfur trioxide-pyridine complex, respectively. The conjugated positions of these compounds were defi...

journal_title：Steroids

authors： Ohkubo T,Wakasawa T,Nambara T

更新日期：1990-03-01 00:00:00

abstract：:Two dimeric steroidal terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols were prepared starting from cholesterol in a five-step synthetic sequence. X-ray crystallography shows that the obtained compounds display novel supramolecular networks in the solid state in which the facial hydrophobicity of the st...

journal_title：Steroids

authors： Alarcón-Manjarrez C,Arcos-Ramos R,Álamo MF,Iglesias-Arteaga MA

更新日期：2016-05-01 00:00:00

abstract：:Aromatase (CYP19A1) is an integral membrane enzyme that catalyzes the removal of the 19-methyl group and aromatization of the A-ring of androgens. All human estrogens are synthesized from their androgenic precursors by this unique cytochrome P450. The crystal structure of active aromatase purified from human placenta ...

journal_title：Steroids

authors： Ghosh D,Jiang W,Lo J,Egbuta C

更新日期：2011-07-01 00:00:00

abstract：:In addition to using radioimmunoassays for the determination of estrogens and other steroids, the possibility of using mass fragmentography for analysis was investigated. t-Butyldimethylsilyl chloride was selected as a reagent for derivatisation because it forms rather stable silylethers. In all the mass-spectra obrai...

journal_title：Steroids

authors： Ballhorn L,Mueller WF,Korte F

更新日期：1979-04-01 00:00:00

abstract：:The apolar ecdysteroid present in the developing embryo of the blue crab, Callinectes sapidus Rathbun, is tentatively identified as ponasterone A (2 beta, 14 alpha, 20,22-pentahydroxy-5, beta-cholest-7-en-6-one) on the basis of chromatographic, immunological, and mass spectral evidence. The apolar ecdysteroid present ...

journal_title：Steroids

authors： McCarthy JF

更新日期：1979-12-01 00:00:00

abstract：:The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

journal_title：Steroids

authors： Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

更新日期：2011-09-01 00:00:00

abstract：:The steroid receptor-positive human ovarian cancer (BG-1) was evaluated to determine its usefulness as a tumor model. This tumor grows in intact male and female nude mice without hormone supplements. Moreover, its growth was significantly accelerated in ovariectomized mice, and the increased growth rate could be rever...

journal_title：Steroids

authors： Zimniski SJ,Garola RE,Fendl K,Peterson CM

更新日期：1989-12-01 00:00:00

abstract：:We describe the development of a serum chlormadinone acetate (CMA) time-resolved fluoroimmunoassay (TR-FIA). We prepared haptens (3-CMO-chlormadinone acetate and 6-chloropregna-4,6-dien-17,20-diol-3-one-20-hemisuccinate), biotinylated tracers (3(biotinylaminopropylamido) 3-CMO-chlormadinone acetate and 3-(6-chloropreg...

journal_title：Steroids

authors： Fiet J,Giton F,Auzerie J,Galons H

更新日期：2002-12-01 00:00:00

abstract：:The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in ...

journal_title：Steroids

authors： Thongbuakaew T,Siangcham T,Suwansa-ard S,Elizur A,Cummins SF,Sobhon P,Sretarugsa P

更新日期：2016-03-01 00:00:00

abstract：:Sphenocentrum jollyanum seeds (MeOH extract and n butanol fraction) exhibited urease inhibitory activity (IC50 40.0 ± 0.92, 28.6 ± 0.41). The Ethyl acetate (EtOAc) fraction gave significant antacid activity with an increase in the baseline pH value of 1.2 to 1.61 ± 0.00 and 1.53 ± 0.00 at 50 and 100 mg, respectively, ...

journal_title：Steroids

authors： Akinwumi IA,Sonibare MA,Yeye EO,Khan M

更新日期：2020-07-01 00:00:00

abstract：:Estradiol benzoate (EB) has been one of the most widely used estrogenic agents in animal husbandry, as a way of exogenously introducing the natural hormone estradiol-17β into the animal organism. Estradiol was previously employed to induce anabolic effects or reproductive improvements in cattle. However, the employmen...

journal_title：Steroids

authors： Regal P,Nebot C,Díaz-Bao M,Barreiro R,Cepeda A,Fente C

更新日期：2011-03-01 00:00:00

abstract：:In this paper, we examine corticosteroid 11 beta-oxidation and 11-reduction as properties of the microsomal 11 beta-hydroxysteroid dehydrogenase complex in vertebrate livers. No hepatic activity in the oxidative direction (11 beta -dehydrogenase) was found in the frog, toad, mud puppy, shark, and bird livers. In contr...

journal_title：Steroids

authors： Monder C,Lakshmi V

更新日期：1988-11-01 00:00:00

abstract：:2,2,6,6-Tetramethyl piperidine-N-oxyl nitroxyls are known to partition between aqueous and lipid phases, thus serving as probes to study membrane dynamics. The synthesis of a novel steroidal spin label, 3alpha-hydroxycholan-24-yl-(2",2",6",6"-tetramethyl-N-oxyl)p iperidyl butan-1',4'-dioate, containing 2,2,6,6-tetrame...

journal_title：Steroids

authors： Katoch R,Trivedi GK,Phadke RS

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Serum progesterone (P) rises after ovulation in the luteinisation process. OBJECTIVE:To identify an accurate progesterone threshold to confirm ovulation in the assessment of a woman's fertility. METHODS:In a secondary analysis of an observational European multicentre study, this study included 107 women ov...

journal_title：Steroids

authors： Leiva R,Bouchard T,Boehringer H,Abulla S,Ecochard R

更新日期：2015-09-01 00:00:00

abstract：:Bile acid conjugates are found in human breast cyst fluid in average concentrations about 50-fold greater than those in blood. Because epidemiologic studies have linked colon and breast cancer and aberrant bile acid profiles are associated with colon cancer risk, we decided to study the influence of bile acid conjugat...

journal_title：Steroids

authors： Raju U,Katz J,Levitz M

更新日期：1997-10-01 00:00:00

abstract：:Phytochemical characterization of a commercial herb sample supplied as Smilax ornata Lem. (sarsaparilla) led to the isolation of five steroidal saponins, including two new furostanol saponins sarsaparilloside B (1) and sarsaparilloside C (2), whose structures were elucidated via a combination of multistage mass spectr...

journal_title：Steroids

authors： Challinor VL,Parsons PG,Chap S,White EF,Blanchfield JT,Lehmann RP,De Voss JJ

更新日期：2012-04-01 00:00:00

abstract：:Incubation of aldosterone with confluent layers of A6 (toad kidney) cells leads to its hydroxylation at the 6 beta-position. 6 beta-Hydroxyaldosterone is the major metabolite when the incubation is carried out at pH 6.8, whereas the product comprises 6 beta-hydroxy-17-isoaldosterone accompanied by some 6 beta-hydroxya...

journal_title：Steroids

authors： Morris DJ,Latif SA,Conca TJ,Wei LT,Watlington CO,Kirk DN,Toms HC,Shackleton CH

更新日期：1990-11-01 00:00:00

abstract：:The sterol mixture of the southern Japan's soft coral, Sarcophyton glaucum, was found to contain 11 sterols including a novel sterol, 23,24 xi-dimethylcholesta-5,22-dien-3 beta-ol and a new diunsaturated C29 sterol. 22,23-Dihydrobrassicasterol and gorgosterol were the major components in free- and esterified sterols r...

journal_title：Steroids

authors： Kobayashi M,Tomioka A,Mitsuhashi H

更新日期：1979-09-01 00:00:00

abstract：:Corticosteroids were used normally as anti-inflammatory drugs. However, in some area certain corticosteroids might be illegally used as growth promoting agent in feed, and as prohibited doping substances in game and sport for human or/and animal performance-enhancing. Synthesized structural similar corticosteroids wer...

journal_title：Steroids

authors： Chen SY,Fang M,Lin YT,Tsai CF,Cheng HF,Wang DY

更新日期：2021-01-01 00:00:00