Abstract：
:The ring A monoglucuronides and monosulfates of 2-hydroxyestriol were synthesized from 2-hydroxyestriol 16,17-diacetate by means of the Koenigs-Knorr reaction with methyl alpha-acetobromoglucuronate and sulfation with sulfur trioxide-pyridine complex, respectively. The conjugated positions of these compounds were definitely established by conversion to 2-hydroxyestriol monomethyl ethers by methylation, then enzymatic hydrolysis. The ring D monoglucuronides and monosulfates of 2-hydroxyestriol were also prepared from 2-hydroxyestriol 2,3-dibenzyl ether by glucuronidation and sulfation in a similar fashion followed by debenzylation, respectively. The positions of conjugation were established on the basis of their 1H-nuclear magnetic resonance spectral data.
journal_name
Steroidsjournal_title
Steroidsauthors
Ohkubo T,Wakasawa T,Nambara Tdoi
10.1016/0039-128x(90)90009-zsubject
Has Abstractpub_date
1990-03-01 00:00:00pages
128-32issue
3eissn
0039-128Xissn
1878-5867pii
0039-128X(90)90009-Zjournal_volume
55pub_type
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