Abstract:
:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectroscopic analyses, X-ray crystallographic analysis and comparison of the NMR data with those of the closely related compounds previously reported. Nodulisporisteriod A (1) and nodulisporisteriod B (2) possess new carbon skeletons, which are the first cases of fission at C-3,4 in 4-methyl-progesteroids. A hypothetical biosynthetic pathway for 1 and 2 was proposed. Moreover, the Aβ42 aggregation inhibitory activities of 1-4 were evaluated using standard thioflavin T (ThT) fluorescence assay with epigallocatechin gallate (EGCG) as positive control. Demethoxyviridin (3) displayed anti-Aβ42 aggregation activity with IC50 value of 13.4μM.
journal_name
Steroidsjournal_title
Steroidsauthors
Zheng QC,Chen GD,Kong MZ,Li GQ,Cui JY,Li XX,Wu ZY,Guo LD,Cen YZ,Zheng YZ,Gao Hdoi
10.1016/j.steroids.2013.05.007subject
Has Abstractpub_date
2013-09-01 00:00:00pages
896-901issue
9eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00107-4journal_volume
78pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Eleven new 14,15-seco-pregnane-type steroidal glycosides, cynanosides P1-P5, Q1-Q3, R1-R3, and a novel 12,13-seco-14,18-nor-pregnane-type steroidal glycoside, cynanoside S, were isolated from the roots of Cynanchum atratum, together with four known compounds, atratoside C, sublanceoside E3, chekiangensoside C and cyna...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.10.007
更新日期:2009-02-01 00:00:00
abstract::The abundant expression of progesterone receptors (PR) in human meningiomas is well established. It is unknown, however, how PR expression is regulated, especially since estrogen receptors (ER) are virtually absent in these tumors. At the mRNA level, ER splice variants occur in meningioma but these appear not to be in...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(00)00193-8
更新日期:2000-10-01 00:00:00
abstract::Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90063-0
更新日期:1982-04-01 00:00:00
abstract::The LNCaP-Fast Growing Colony (FGC) human prostate cancer cell line proliferates in response to the addition of dihydrotestosterone (DHT) 10(-10)-10(-8) M in charcoal-stripped serum-supplemented media. LNCaP-FGC cells will not attach or proliferate in serum-free conditions. LNCaP-FGC stock cultures were maintained in ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(93)90084-z
更新日期:1993-09-01 00:00:00
abstract::The binding characteristics and quantitation of the recently reported fetal steroid binding protein (FSBP) cannot be determined on unpurified samples; an immunoassay was therefore desirable. The protein was purified to homogeneity in order to raise a highly specific polyclonal antibody. An enzyme-linked immunosorbent ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90063-7
更新日期:1985-01-01 00:00:00
abstract::Human mammary medullary carcinoma cells (passages 16 to 21) were cultured for 2 days to allow for attachment, followed by 6 days of culture in either fetal calf serum, human cord blood, human amniotic fluid, or growth factors in the presence or absence of purified human alpha-fetoprotein (AFP). When growth factors wer...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90042-t
更新日期:1991-05-01 00:00:00
abstract::Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00112-x
更新日期:2001-11-01 00:00:00
abstract::Steroid hormones are involved in the regulation of a variety of processes like embryonic development, sex differentiation, metabolism, immune responses, circadian rhythms, stress response, and reproduction in vertebrates. Teleost fishes and humans show a remarkable conservation in many developmental and physiological ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.06.011
更新日期:2015-11-01 00:00:00
abstract::This paper revealed the expression pattern of ERα in the ovoviviparous teleost, Sebastes schlegeli. In this paper, we isolated the cDNA encoding for estrogen receptor alpha of black rockfish (S. schlegeli) from its ovary, named as black rockfish ERα (brfERα). The cDNA sequence of brfERα consists of 2972bp with an open...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.09.014
更新日期:2011-12-20 00:00:00
abstract::Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.10.005
更新日期:2006-03-01 00:00:00
abstract::We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.05.009
更新日期:2011-09-01 00:00:00
abstract::Circulation levels of estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHAS) have been measured in plasma using a radioimmunoassay for estrone and dehydroepiandrosterone following extraction and hydrolysis of the sulfate. The mean +/- SE concentrations of E1S and DHAS in normal men were 458 +/- 25 pg/ml and 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(79)80017-3
更新日期:1979-11-01 00:00:00
abstract::Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00108-7
更新日期:2000-04-01 00:00:00
abstract::The effect of cortisol and prostaglandin inhibitors on the growth and development of germinating mung bean, Vigna radiata L. Wilzek, cv. Jumbo was investigated. Cortisol, indomethacin, and a mixture of cortisol with aspirin, or benoxaprofen significantly increased radicle length and the number of lateral roots as comp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90052-2
更新日期:1985-08-01 00:00:00
abstract::Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90029-6
更新日期:1978-04-01 00:00:00
abstract::The mechanistic aspects of the alkali-catalyzed rearrangement of 16alpha-hydroxy-17-keto steroid 1 to 17beta-hydroxy-16-keto steroid 2 are elucidated by use of (18)O- and deuterium-labeling experiments. The (18)O-labeling experiments refute the gem-hydration-quasi-diaxial dehydration mechanism for the rearrangement pr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.03.001
更新日期:2008-09-01 00:00:00
abstract::Exposure of immature rat ovaries to pregnant mare's serum gonadotropin (PMS) results in a prompt increase in testosterone and progesterone output but synthesis of estradiol (E2) increases only after a lag period of several hours. Actinomycin D (Act-D) given with PMS did not inhibit testosterone or progesterone product...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90004-6
更新日期:1977-03-01 00:00:00
abstract::Using beta-sitosterol as a starting material, (6E)-hydroximino-24-ethylcholest-4-en-3-one (1), a natural steroidal oxime from Cinachyrella alloclada and C. apion, was synthesized in four steps with a high overall yield. First, beta-sitosterol (5a) is transformed into the corresponding 24-ethylcholest-4-en-3,6-dione (6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.10.007
更新日期:2008-03-01 00:00:00
abstract::While the neuroprotective benefits of estrogen and progesterone in critical illness are well established, the data regarding the effects of androgens are conflicting. Surgical repair of congenital heart disease is associated with significant morbidity and mortality, but there are scant data regarding the postoperative...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.11.003
更新日期:2014-03-01 00:00:00
abstract::Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.01.003
更新日期:2004-04-01 00:00:00
abstract::Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas def...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90032-5
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. EXPERIMENTAL:We evaluated 30 young (27±1 year) premenopausal, non-obese (23±0.5 kg/m(2)), normally...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.06.001
更新日期:2011-11-01 00:00:00
abstract::Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.05.019
更新日期:2004-09-01 00:00:00
abstract::This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.12.011
更新日期:2008-04-01 00:00:00
abstract::13beta-Ethyl-3-methoxy-17beta-ol-8,14-seco-1,3,5(10),8-gonatetraen-14-one (IIIa) was isolated and its participation in the well-known acidic cyclization process was established. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90015-x
更新日期:1975-05-01 00:00:00
abstract:INTRODUCTION:ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases. METHOD:ERα36 expression was examined using immunohistochemical methods with sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was also studi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::Two new sterols, (24E)-24-n-propylidenecholesterol and 24 epsilon-n-propylcholesterol, were isolated from a cultured marine Chrysophyte. Since most of the steroids found in marine invertebrates are unchanged or modified sterols of algal or symbiotic origin, the discovery of these two unusual sterols in a unicellular a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90104-x
更新日期:1980-02-01 00:00:00
abstract::Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to pregnenolone nor progesterone to corticoid hormones. When given orally to rats, trilostane inhibits corticosterone and aldo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90010-7
更新日期:1978-09-01 00:00:00
abstract::The therapeutic use of progesterone following traumatic brain injury has recently entered phase III clinical trials as a means of neuroprotection. Although it has been hypothesized that progesterone protects against calcium overload following excitotoxic shock, the exact mechanisms underlying the beneficial effects of...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.013
更新日期:2011-08-01 00:00:00
abstract::During the second half of the luteal phase, the human corpus luteum becomes responsive to regular luteinizing hormone (LH) pulses. These LH pulses stimulate progesterone secretion tonically, and during this tonic stimulation, additional LH-independent progesterone pulses occur, which are particularly pronounced in wom...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(98)00037-3
更新日期:1998-05-01 00:00:00