Synthesis of multiply 13C-labeled furofuran lignans using 13C-labeled cinnamyl alcohols as building blocks.

abstract：:Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...

journal_title：Steroids

authors： Xiao BG,Liu X,Link H

更新日期：2004-09-01 00:00:00

abstract：:Fourteen esters (formate, acetate, propionate, butyrate, hexanoate, heptanoate, and benzoate) located at C-11 of 11 beta-hydroxyesterone and 11 beta-hydroxyestradiol-17 beta were synthesized and evaluated for uterotropic and gonadotropin release inhibition in rats, as well as their ability to displace (3H) estradiol-1...

journal_title：Steroids

authors： Segaloff A,Gabbard RB

更新日期：1984-01-01 00:00:00

abstract：:This article describes the oxidation of cholesta-5,7-dien-3beta-yl acetate (4) with the urea-hydrogen peroxide adduct (UHP) using methyltrioxorhenium (MTO) as catalyst, under various conditions. Specifically, the effects of using different solvents (CHCl(3) and ethers) and additives (EtOH and pyridine) on the course o...

journal_title：Steroids

authors： Musumeci D,Sica D

更新日期：2002-06-01 00:00:00

abstract：:Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen...

journal_title：Steroids

authors： El-Desoky el-SI,Reyad M,Afsah EM,Dawidar AA

更新日期：2016-01-01 00:00:00

abstract：:Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...

journal_title：Steroids

authors： Scheddin D,Mayer H,Schönecker B,Gliesing S,Reichenbächer M

更新日期：1998-12-01 00:00:00

abstract：:Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. The influence of steroids on inflammatory processes has long been established since glucocorticoids and their receptor belong to the regulatory network involved in inhibition of several inflamma...

journal_title：Steroids

authors： Sadowska AM,Klebe B,Germonpré P,De Backer WA

更新日期：2007-01-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), the enzyme that catalyzes the conversion of biologically active glucocorticoids to their inactive metabolites, was shown to be located exclusively in Leydig cells of the rat testis, and its appearance was associated with the developmental rise in testosterone. Thus, ...

journal_title：Steroids

authors： Nacharaju VL,Muneyyirci-Delale O,Khan N

更新日期：1997-03-01 00:00:00

abstract：:Sertoli cells isolated from 17 day old rats were maintained in culture and incubated with [14C]-progesterone for 20 h. The cells and media were extracted with ether/chloroform and the extracts chromatographed two-dimensionally on TLC and the radioactive metabolites visualized by autoradiography. Nine of the metabolite...

journal_title：Steroids

authors： Wiebe JP,Tilbe KS,Buckingham KD

更新日期：1980-05-01 00:00:00

abstract：:The abilities of a variety of estrogens and antiestrogens to stimulate DNA synthesis in the prepuberal rat uterus were compared. One microgram of each compound was administered in vivo via a single intraperitoneal injection. DNA synthesis was assayed in vitro in isolated nuclei 24 h later. The relative mitogenicities ...

journal_title：Steroids

authors： Stack G,Korach K,Gorski J

更新日期：1989-08-01 00:00:00

abstract：:To simultaneously measure some targeted endocrine disruptors and several forms of sex hormones in rat serum, an accurate analytical procedure was developed. First, a comparison between a polymeric-based solid-phase extraction (SPE) and a micro-extraction by packed sorbent was performed to choose the optimal method to ...

journal_title：Steroids

authors： Tournier M,Pouech C,Quignot N,Lafay F,Wiest L,Lemazurier E,Cren-Olivé C,Vulliet E

更新日期：2015-12-01 00:00:00

abstract：:Some intermediates in the cholesterol biosynthesis between lanosterol and cholesterol are capable of inducing resumption of meiosis in cultured mouse oocytes without the presence of gonadotropins. The mechanism by which these so-called Meiosis Activating Sterols (MAS) activate the meiotic process is unknown, and it is...

journal_title：Steroids

authors： Yding Andersen C,Byskov AG

更新日期：2002-11-01 00:00:00

abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...

journal_title：Steroids

authors： Mihailidou AS,Ashton AW

更新日期：2014-12-01 00:00:00

abstract：:This study examines the distribution of 5 alpha-reductase and 3 alpha(beta)-hydroxysteroid dehydrogenase activities throughout the intact hyperplastic prostate gland and relate these measurements to the fibromuscular/epithelial composition and to the gross glandular morphology. The relative capacities of the stroma an...

journal_title：Steroids

authors： Habib FK,Beynon L,Chisholm GD,Busuttil A

更新日期：1983-01-01 00:00:00

abstract：:Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...

journal_title：Steroids

authors： Hnilickova J,Kohout L,Capdevila E,Esteve A,Vilaplana M,Molist M,Brosa C,Swaczynova-Oklestkova J,Slavikova B

更新日期：2010-12-01 00:00:00

abstract：:A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three can...

journal_title：Steroids

authors： Agarwal DS,Siva Krishna V,Sriram D,Yogeeswari P,Sakhuja R

更新日期：2018-11-01 00:00:00

abstract：:The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

journal_title：Steroids

authors： Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

更新日期：2011-09-01 00:00:00

abstract：:Estrogen plays a central role in the control of reproductive behaviour and in the regulation of neuroendocrine system. To elucidate the mechanism by which it controls the stress-modulated functions, it is important to understand how estrogenic effects are mediated. The distribution of estrogen receptor alpha (ERα) pro...

journal_title：Steroids

authors： Niranjan MK,Srivastava R

更新日期：2019-06-01 00:00:00

abstract：:The preparation of 9alpha, 11xi-tritiated 17alpha-ethinyl estradiol, mestranol, estradiol-17beta, and norethindrone are described. Estrone-3-methyl ether was employed as starting material, and ethinylation with lithium acetylide-ethylene diamine resulted in 95% mestranol. Demethylation of mestranol with boron tribro...

journal_title：Steroids

authors： Rao PN

更新日期：1971-08-01 00:00:00

abstract：:The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testosterone-3-(carboxymethyl) oxime-peroxidase by the mixed anhydride method was found to give a conjugate of high ...

journal_title：Steroids

authors： Rajkowski KM,Cittanova N,Desfosses B,Jayle MF

更新日期：1977-05-01 00:00:00

abstract：:The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employe...

journal_title：Steroids

authors： Rao PN,Khan AH,Moore PH Jr

更新日期：1977-02-01 00:00:00

abstract：:Inhibition of concise enzymes in ergosterol biosynthesis is one of the most prominent strategies for antifungal chemotherapy. Nevertheless, the enzymes sterol C5-desaturase and sterol C22-desaturase, which introduce double bonds into the sterol core and side chain, have not been fully investigated yet for their potent...

journal_title：Steroids

authors： Müller C,Binder U,Maurer E,Grimm C,Giera M,Bracher F

更新日期：2015-09-01 00:00:00

abstract：:Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...

journal_title：Steroids

authors： Leng T,Liu A,Wang Y,Chen X,Zhou S,Li Q,Zhu W,Zhou Y,Su X,Huang Y,Yin W,Qiu P,Hu H,Xiong ZG,Zhang J,Yan G

更新日期：2016-01-01 00:00:00

abstract：:Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (...

journal_title：Steroids

authors： Popadyuk II,Markov AV,Morozova EA,Babich VO,Salomatina OV,Logashenko EB,Zenkova MA,Tolstikova TG,Salakhutdinov NF

更新日期：2017-11-01 00:00:00

abstract：:The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...

journal_title：Steroids

authors： Alvarez M,Jover A,Carrazana J,Meijide F,Soto VH,Tato JV

更新日期：2007-06-01 00:00:00

abstract：:The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the s...

journal_title：Steroids

authors： Bartke A,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...

journal_title：Steroids

authors： Ekhato IV,Hurley T,Lovdahl M,Revitte TJ,Guo L,Huang Y,Clipper S,Colson C

更新日期：2002-03-01 00:00:00

abstract：:Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...

journal_title：Steroids

authors： Kelly MJ,Rønnekleiv OK,Ibrahim N,Lagrange AH,Wagner EJ

更新日期：2002-05-01 00:00:00

abstract：:The synthesis of the esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) with three bile acids and of the cholesteryl carbonate of norethisterone are described. :This article reports the synthesis of the esters of norethisterone (17 alpha-ethynl-17beta-hydroxyestr-4-en-3-one) with 3 bile acids ...

journal_title：Steroids

authors： Herz JE,Sandoval J

更新日期：1983-03-01 00:00:00

abstract：:Chronic kidney disease results in a reduction in 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and an accumulation of phosphorus in the blood, leading to secondary hyperparathyroidism and renal osteodystrophy. Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than...

journal_title：Steroids

authors： Williams KB,DeLuca HF

更新日期：2008-11-01 00:00:00

abstract：:Mouse models of cystic fibrosis (CF) display increased sulfotransferase 1E1 (SULT1E1) activity in hepatocytes of cystic fibrosis transmembrane receptor (CFTR)-deficient animals. SULT1E1 is responsible for the sulfation and inactivation of beta-estradiol (E2) at physiological concentrations. IGF-1 message levels in CFT...

journal_title：Steroids

authors： Li L,He D,Wilborn TW,Falany JL,Falany CN

更新日期：2009-01-01 00:00:00