Abstract:
:Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen-androgen hormone replacement therapy treatment. The analog also offers special possibilities for the prevention/treatment of hormone-sensitive cancers. The testosterone skeleton has important functionalities in the molecule that can act as a carbonyl component, an active methylene compound, α,β-unsaturated enone and tertiary hydroxyl group in various chemical reactions to access stereoisomeric steroidal compounds with potent activity. In addition, microbiological methods of synthesis and transformation of this hormone are presented.
journal_name
Steroidsjournal_title
Steroidsauthors
El-Desoky el-SI,Reyad M,Afsah EM,Dawidar AAdoi
10.1016/j.steroids.2015.11.004subject
Has Abstractpub_date
2016-01-01 00:00:00pages
68-95eissn
0039-128Xissn
1878-5867pii
S0039-128X(15)00291-3journal_volume
105pub_type
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