Metabolism of estrogens by rabbit blastocysts: formation of estrogen glucosides and preferential conversion of estrone to estradiol-17 beta.

abstract：:The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membran...

journal_title：Steroids

authors： Castelnovo LF,Magnaghi V,Thomas P

更新日期：2019-02-01 00:00:00

abstract：:3 beta-Hydroxy-5-androsten-17-one is converted to 5-androstene-3, 17-dione by rat liver alcohol dehydrogenase (ADH). We have reported on the purity of the enzyme which is eluted with pyrazole as a single homogeneous protein using an AMP-agarose affinity column. Rat liver ADH can oxidize hydroxyl groups not only at 3 b...

journal_title：Steroids

authors： Knutson VP,Ungar F

更新日期：1982-11-01 00:00:00

abstract：:Phytochemical characterization of a commercial herb sample supplied as Smilax ornata Lem. (sarsaparilla) led to the isolation of five steroidal saponins, including two new furostanol saponins sarsaparilloside B (1) and sarsaparilloside C (2), whose structures were elucidated via a combination of multistage mass spectr...

journal_title：Steroids

authors： Challinor VL,Parsons PG,Chap S,White EF,Blanchfield JT,Lehmann RP,De Voss JJ

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Chronic administration of exogenous glucocorticoids is often required in experimental research. We compared the efficacy and reliability of three different methods of continuous glucocorticoid administration in mice. MATERIALS AND METHODS:Male CD1 Swiss White mice aged 7-9 weeks received corticosterone (CS)...

journal_title：Steroids

authors： Herrmann M,Henneicke H,Street J,Modzelewski J,Kalak R,Buttgereit F,Dunstan CR,Zhou H,Seibel MJ

更新日期：2009-02-01 00:00:00

abstract：:The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...

journal_title：Steroids

authors： Vázquez-Ramírez I,Macías-Alonso M,Arcos-Ramos RO,Ruíz-Pérez KM,Solano-Ramírez DO,Iglesias Arteaga MA

更新日期：2008-07-01 00:00:00

abstract：:Two unnatural steroid sapogenins bearing a furospirostane side chain were prepared starting from the readily available spirostane sapogenins, tigogenin and diosgenin following a synthetic protocol that included: (i) introduction of a carbonyl group at position C-23, (ii) diacetoxyiodobenzene-induced F-ring contraction...

journal_title：Steroids

authors： Sánchez-Flores J,Romero-Ávila M,Rosado-Abón A,Flores-Álamo M,Iglesias-Arteaga MA

更新日期：2013-09-01 00:00:00

abstract：:The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testosterone-3-(carboxymethyl) oxime-peroxidase by the mixed anhydride method was found to give a conjugate of high ...

journal_title：Steroids

authors： Rajkowski KM,Cittanova N,Desfosses B,Jayle MF

更新日期：1977-05-01 00:00:00

abstract：:A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The "one pot" reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a ...

journal_title：Steroids

authors： Grisenti P,Magni A,Manzocchi A,Ferraboschi P

更新日期：1997-06-01 00:00:00

abstract：:The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...

journal_title：Steroids

authors： Zaretskii ZV

更新日期：1979-05-01 00:00:00

abstract：:Inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) regulate the activity of the hypothalamo-pituitary-adrenal (HPA) axis at several levels. Although hypothalamic CRH secretion may be the primary mechanism by which these cytokines activate the HPA axis, IL-1 expression is increased within t...

journal_title：Steroids

authors： Tkachenko IV,Jääskeläinen T,Jääskeläinen J,Palvimo JJ,Voutilainen R

更新日期：2011-09-01 00:00:00

abstract：:We synthesized various analogues of 1alpha,25-(OH)(2)D(3)-26,23-lactone and examined the effects of them on HL-60 cell differentiation using the evaluation system of the genomic action of 1alpha,25-(OH)(2)D(3). We found that (23S)- and (23R)-25-dehydro-1alpha-OH-D(3)-26,23-lactone (TEI-9647 and TEI-9648) strongly boun...

journal_title：Steroids

authors： Ishizuka S,Miura D,Ozono K,Saito M,Eguchi H,Chokki M,Norman AW

更新日期：2001-03-01 00:00:00

abstract：:A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels in...

journal_title：Steroids

authors： Lees ND,Kleinhans FW,Broughton MC,Pennington DE,Ricker VA,Bard M

更新日期：1989-03-01 00:00:00

abstract：:The sterol mixture of the southern Japan's soft coral, Sarcophyton glaucum, was found to contain 11 sterols including a novel sterol, 23,24 xi-dimethylcholesta-5,22-dien-3 beta-ol and a new diunsaturated C29 sterol. 22,23-Dihydrobrassicasterol and gorgosterol were the major components in free- and esterified sterols r...

journal_title：Steroids

authors： Kobayashi M,Tomioka A,Mitsuhashi H

更新日期：1979-09-01 00:00:00

abstract：:(24R and 24S)-5beta-cholestane-3alpha,7alpha,24,25-tetrols were prepared by osmium tetroxide oxidation of 5beta-cholest-24-ene-3alpha,7alpha-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and ...

journal_title：Steroids

authors： Batta AK,Dayal B,Tint GS,Shefer S,Toome V,Salen G,Mosbach EH

更新日期：1978-01-01 00:00:00

abstract：:Although aldosterone production declines with age, so does the aldosterone metabolic clearance rate (MCR), and the net effect of age on the circulating level of aldosterone may be less than can be predicted from production rates alone. The effect of age on aldosterone production and plasma levels was studied in a grou...

journal_title：Steroids

authors： Pratt JH,Hawthorne JJ,Debono DJ

更新日期：1988-01-01 00:00:00

abstract：:Human progesterone receptor (PR) contains a polyproline motif in the amino-terminal domain that interacts with the SH3 domain of Src and mediates rapid activation of c-Src and downstream MAPK (Erk-1/-2) independent of the transcriptional activity of PR. Forcedly target PR to different locations in the cell by use of m...

journal_title：Steroids

authors： Boonyaratanakornkit V,Bi Y,Rudd M,Edwards DP

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligand but whether this steroid can support osteoblast maturation has not be...

journal_title：Steroids

authors： Mansell JP,Shorez D,Farrar D,Nowghani M

更新日期：2009-11-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...

journal_title：Steroids

authors： Choi YS,Yang HI,Cho S,Jung JA,Jeon YE,Kim HY,Seo SK,Lee BS

更新日期：2012-11-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...

journal_title：Steroids

authors： Gocek E,Kiełbiński M,Wyłób P,Kutner A,Marcinkowska E

更新日期：2008-12-22 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder due to mutation in the CYP21A2 gene. OBJECTIVE:To elucidate the genetic basis of 21-hydroxylase-deficient CAH in Hong Kong Chinese patients. PATIENTS AND METHODS:Mutational analysis of the CY...

journal_title：Steroids

authors： Chan AO,But WM,Ng KL,Wong LM,Lam YY,Tiu SC,Lee KF,Lee CY,Loung PY,Berry IR,Brown R,Charlton R,Cheng CW,Ho YC,Tse WY,Shek CC

更新日期：2011-09-01 00:00:00

abstract：:This paper describes three simple and short methods for the conversion of cholic acid into cholylaldehyde with protected hydroxyl groups. The first method involves lithium aluminum hydride reduction of the tetrahydropyranyl ether of methyl cholate and oxidation of the resulting primary alcohol with pyridinium chloroch...

journal_title：Steroids

authors： Batta AK,Tint GS,Dayal B,Shefer S,Salen G

更新日期：1982-06-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17 beta-HSD is performed by at least five 17 beta-HSD isoenzymes having individual cell-specific expression, substrate specificity, regulation mechanisms, and reductive or...

journal_title：Steroids

authors： Labrie F,Luu-The V,Lin SX,Labrie C,Simard J,Breton R,Bélanger A

更新日期：1997-01-01 00:00:00

abstract：:Four new pregnane glycosides, stelmatocryptonoside A, B, C, and D (1-4), were isolated from the stems of Stelmatocrypton khasianum. On the basis of chemical and spectral data, the structures of 1-4 were established as 3beta, 16alpha-dihydroxy-pregn-5-en-20-one-16-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-...

journal_title：Steroids

authors： Zhang Q,Zhao Y,Wang B,Feng R,Liu X,Cheng T

更新日期：2002-04-01 00:00:00

abstract：:It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...

journal_title：Steroids

authors： Shany S,Levy Y,Lahav-Cohen M

更新日期：2001-03-01 00:00:00

abstract：:The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...

journal_title：Steroids

authors： Higashi T,Miura K,Kikuchi R,Shimada K,Hiyamizu H,Ooi H,Iwabuchi Y,Hatakeyama S,Kubodera N

更新日期：2000-05-01 00:00:00

abstract：:A method for the synthesis and purification of 6beta-iodomethyl-19-norcholest-5(10)-ene-3beta-ol-131I of greater than 98 mole% chemical purity and greater than 99% radiochemical purity is presented. Carbon-13 and proton NMR were used to establish the identity and purity. Discrepancies in the characterization of this c...

journal_title：Steroids

authors： Scott KN,Couch MW,Mareci TH,Williams CM

更新日期：1976-08-01 00:00:00

abstract：:Two variants of the Claisen rearrangement were evaluated for a stereoselective construction of a C-25 stereogenic center in cholestenoic acids based on 1,4-chirality transfer. Johnson orthoester Claisen rearrangement of (22R)- and (22S)-propargyl enol ethers proceeded in a highly stereoselective manner to give (25R)- ...

journal_title：Steroids

authors： Ermolovich YV,Zhabinskii VN,Khripach VA

更新日期：2013-07-01 00:00:00

abstract：:Because diffusion of testosterone (T) into the salivary gland is thought to be largely limited to the free, biologically active fraction, salivary testosterone is expected to provide a better measure of testosterone bioavailability in the body than is plasma testosterone. Matched saliva and blood spot samples were col...

journal_title：Steroids

authors： Rilling JK,Worthman CM,Campbell BC,Stallings JF,Mbizva M

更新日期：1996-06-01 00:00:00

abstract：:Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...

journal_title：Steroids

authors： Martin GD,Narvaez J,Bulmer R,Durrant MC

更新日期：2016-09-01 00:00:00

abstract：:Steroid hormone is extensively used for transmitting variety of biological signals in organisms. Natural steroid hormone is synthesized from cholesterol in adrenal cortex and in sexual gland in vertebrates. Appropriately dosed synthetic steroid hormones can be used for medication. Despite their positive effects as med...

journal_title：Steroids

authors： Hori-Tanaka Y,Yura K,Takai-Igarashi T,Tanaka H

更新日期：2015-04-01 00:00:00