Abstract：
:Phytochemical characterization of a commercial herb sample supplied as Smilax ornata Lem. (sarsaparilla) led to the isolation of five steroidal saponins, including two new furostanol saponins sarsaparilloside B (1) and sarsaparilloside C (2), whose structures were elucidated via a combination of multistage mass spectrometry (MS(n)), 1D and 2D NMR experiments, and chemical degradation. The previously unreported spectroscopic characterization of sarsaparilloside (3), Δ(20(22))-sarsaparilloside (4), and parillin (5) is also provided. The antiproliferative activity of the isolated saponins was compared in six human cell lines derived from different tumor types and one of the structures (2) was particularly active against the HT29 colon tumor cell line.
journal_name
Steroidsjournal_title
Steroidsauthors
Challinor VL,Parsons PG,Chap S,White EF,Blanchfield JT,Lehmann RP,De Voss JJdoi
10.1016/j.steroids.2012.01.009subject
Has Abstractpub_date
2012-04-01 00:00:00pages
504-11issue
5eissn
0039-128Xissn
1878-5867pii
S0039-128X(12)00031-1journal_volume
77pub_type
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