New progesterone metabolites in human myometrium.

abstract：:Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...

journal_title：Steroids

authors： Choi YS,Yang HI,Cho S,Jung JA,Jeon YE,Kim HY,Seo SK,Lee BS

更新日期：2012-11-01 00:00:00

abstract：:7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers ...

journal_title：Steroids

authors： Duval D,Prédine J,Emiliozzi R,Milgrom E

更新日期：1980-01-01 00:00:00

abstract：:The influence of daily injections, for 7 days, of 17-hydroxyprogesterone caproate (8 mg/100 g body weight pro die), of estradiol-17 beta 17-undecylate (1.2 mg/100 g body weight pro die) of testosterone enanthate (2 mg/100 g body weight pro die) and of ACTH (4 IU/100 g body weight pro die) to male Wistar rats, weighing...

journal_title：Steroids

authors： Bukhari AR,Guessab A,Nicol ML

更新日期：1981-07-01 00:00:00

abstract：:Circadian rhythms in physiology and behavior are known to be influenced by the estrous cycle in female rodents. The clock genes responsible for the generation of circadian oscillations are widely expressed both within the central nervous system and peripheral tissues, including those that comprise the reproductive sys...

journal_title：Steroids

authors： Nakamura TJ,Sellix MT,Kudo T,Nakao N,Yoshimura T,Ebihara S,Colwell CS,Block GD

更新日期：2010-03-01 00:00:00

abstract：:C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...

journal_title：Steroids

authors： Sholl SA

更新日期：1981-08-01 00:00:00

abstract：:Estradiol (E2), progesterone (P4), and oxytocin (OT) are important for the initiation of luteolysis in ruminants but the mechanisms involved are still poorly understood. The objective of this study was to determine if duration of exposure of bovine endometrial epithelial cells to P4 affected the response of the cells ...

journal_title：Steroids

authors： Kombé A,Sirois J,Goff AK

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Serum progesterone (P) rises after ovulation in the luteinisation process. OBJECTIVE:To identify an accurate progesterone threshold to confirm ovulation in the assessment of a woman's fertility. METHODS:In a secondary analysis of an observational European multicentre study, this study included 107 women ov...

journal_title：Steroids

authors： Leiva R,Bouchard T,Boehringer H,Abulla S,Ecochard R

更新日期：2015-09-01 00:00:00

abstract：:A mechanistic study on the nucleophilic substitution of a strictly geometric 21-bromo-3alpha-hydroxyl-3beta-methoxymethyl-5alpha-pregnan-20-one was described. Reaction of the alpha-bromoketone with excess lithium imidazole followed by the addition of extra bases including n-butyllithium, methyllithium, lithium piperid...

journal_title：Steroids

authors： Chen CY,Wong FF,Lee YH,Chou SY,Huang JJ,Yeh MY

更新日期：2006-11-01 00:00:00

abstract：:The 7 alpha-methyl substituent is reported to increase the binding affinity of estradiol for the estrogen receptor (ER). In order to evaluate whether this substituent would improve the in vitro binding characteristics and the in vivo tissue distribution of 18F labeled estrogens that we are developing as positron emiss...

journal_title：Steroids

authors： VanBrocklin HF,Liu A,Welch MJ,O'Neil JP,Katzenellenbogen JA

更新日期：1994-01-01 00:00:00

abstract：:This article describes the origins and evolution of "antiestrogenic" medicines for the treatment and prevention of breast cancer. Developing drugs that target the estrogen receptor (ER) either directly (tamoxifen) or indirectly (aromatase inhibitors) has improved the prognosis of breast cancer and significantly advanc...

journal_title：Steroids

authors： Jordan VC,Brodie AM

更新日期：2007-01-01 00:00:00

abstract：:Fast atom bombardment/mass spectrometry or liquid secondary ion mass spectrometry provides the capability for direct analysis of steroid conjugates (sulfates, glucuronides) without prior hydrolysis or derivatization. During the analysis of biologic extracts, limitations on the sensitivity of detection arise from the p...

journal_title：Steroids

authors： Gaskell SJ

更新日期：1990-10-01 00:00:00

abstract：:Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...

journal_title：Steroids

authors： Helton ED,Gough BJ,King JW Jr,Thenot JP,Horning EC

更新日期：1978-04-01 00:00:00

abstract：:Chronic kidney disease results in a reduction in 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and an accumulation of phosphorus in the blood, leading to secondary hyperparathyroidism and renal osteodystrophy. Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than...

journal_title：Steroids

authors： Williams KB,DeLuca HF

更新日期：2008-11-01 00:00:00

abstract：:In this study, we investigated the binding characteristics of [3H]Delta(5)-androstene-3beta,17beta-diol to rabbit vaginal cytosolic and nuclear extracts and in freshly excised intact tissue strips. [3H]delta(5)-Androstene-3beta,17beta-diol bound to a protein(s) in the vaginal nuclear extract with high affinity (K(d)=3...

journal_title：Steroids

authors： Traish AM,Huang YH,Min K,Kim NN,Munarriz R,Goldstein I

更新日期：2004-01-01 00:00:00

abstract：:It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...

journal_title：Steroids

authors： Shany S,Levy Y,Lahav-Cohen M

更新日期：2001-03-01 00:00:00

abstract：:Based on histological criteria, Kingsley and Bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. In contrats, Kennedy (4) found in estrogen-pretreated rats that ...

journal_title：Steroids

authors： Kennedy TG,Armstrong DT

更新日期：1976-03-01 00:00:00

abstract：:Significant changes in % free serum E2, T and P were observed during the annual cycle of the turtle. In contrast no significant changes in SHBG affinity constants (2.29-4.48 x 10(8) M-7) were found and binding capacity for estradiol 17B was between 3.47 and 3.96 x 10(-7) M except in preovulatory animals (2.00 +/- 0.25...

journal_title：Steroids

authors： Albert C,Callard IP

更新日期：1988-10-01 00:00:00

abstract：:Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated. A simple method that does not involve extraction but only the 1:100 d...

journal_title：Steroids

authors： Arioli F,Fidani M,Casati A,Fracchiolla ML,Pompa G

更新日期：2010-04-01 00:00:00

abstract：:The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...

journal_title：Steroids

authors： Bozzolino C,Vaglio S,Amante E,Alladio E,Gerace E,Salomone A,Vincenti M

更新日期：2019-10-01 00:00:00

abstract：:Exposure of immature rat ovaries to pregnant mare's serum gonadotropin (PMS) results in a prompt increase in testosterone and progesterone output but synthesis of estradiol (E2) increases only after a lag period of several hours. Actinomycin D (Act-D) given with PMS did not inhibit testosterone or progesterone product...

journal_title：Steroids

authors： Soewoto H,Cheng HC,Johnson DC

更新日期：1977-03-01 00:00:00

abstract：:A sensitive accurate assay for the placental microsomal 3 beta-hydroxysteroid dehydrogenase (E.C.1.1.1.51) has been developed using tritiated substrates. Kinetic analysis of the enzyme with 3 beta-hydroxy-5-androsten-17-one and 3 beta-hydroxy-5-pregnen-20-one indicates that the apparent Km values for these substrates ...

journal_title：Steroids

authors： Gibb W

更新日期：1979-04-01 00:00:00

abstract：:Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...

journal_title：Steroids

authors： Walker WH

更新日期：2009-07-01 00:00:00

abstract：:Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3...

journal_title：Steroids

authors： Halperin G,Gatt S

更新日期：1980-01-01 00:00:00

abstract：:A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17β-hydroxymethyl-2,17α-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The...

journal_title：Steroids

authors： Kratena N,Biedermann N,Stojanovic B,Göschl L,Weil M,Enev VS,Gmeiner G,Gärtner P

更新日期：2019-10-01 00:00:00

abstract：:Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor ...

journal_title：Steroids

authors： Cechin SR,Buchwald P

更新日期：2014-07-01 00:00:00

abstract：:We report the synthesis of 3 beta,15 beta,17 alpha-trihydroxy-5-pregnen-20- one (1) from 3 beta,15 beta-dihydroxy-5,16-pregnadien-20-one (11) in 7 steps using boronate derivatives as a means of protecting the 17,20-glycol side-chain of steroid intermediates. 16 alpha,17 alpha-Epoxy-3 beta,15 beta-dihydroxy-5- pregnen-...

journal_title：Steroids

authors： Joannou GE,Reeder AY

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...

journal_title：Steroids

authors： de Oliveira C,Iwanaga-Carvalho C,Mota JF,Oyama LM,Ribeiro EB,Oller do Nascimento CM

更新日期：2011-11-01 00:00:00

abstract：:Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...

journal_title：Steroids

authors： Haajanen K,Botting NP

更新日期：2006-03-01 00:00:00

abstract：:The configurations at C-24 of 24-alkylsterols of six samples of Clerodendrum species (Verbenaceae) - the aerial parts of C. fragrans, C. inerme, C. infortunatum, C. scandens, and C. siphonanthus, and the seeds of C. infortunatum - were examined by NMR. All samples contained 24 beta-ethylsterols possessing a delta 25-b...

journal_title：Steroids

authors： Akihisa T,Matsubara Y,Ghosh P,Thakur S,Tamura T,Matsumoto T

更新日期：1989-03-01 00:00:00

abstract：:Corticosterone-and progesterone-binding activity were measured by saturation analysis, with dextran-charcoal separation, in plasma obtained from male and female rats, and a normal male and female human. In plasma from normal male and female rats, progesterone was much less effective than corticosterone in displacing 3...

journal_title：Steroids

authors： Calvano SE,Reynolds RW,Keith LD

更新日期：1980-09-01 00:00:00