Sterols of some Clerodendrum species (Verbenaceae): occurrence of the 24 alpha- and 24 beta-epimers of 24-ethylsterols lacking a delta 25-bond.

abstract：:Aldosterone induces fibrotic changes in cardiovascular tissues but its effects have usually been demonstrated in models of pre-existing renal injury and/or hypertension. This study tests the hypothesis that aldosterone can directly induce vascular fibrotic changes in the absence of prior renal injury or hypertension. ...

journal_title：Steroids

authors： Brem AS,Morris DJ,Li X,Ge Y,Shaw S,Gong R

更新日期：2013-03-01 00:00:00

abstract：:Anabolic androgenic steroids (AAS) are testosterone and testosterone-derivative compounds sporadically employed by athletes and increasingly used recreationally to acquire a competitive edge or improve body composition. Nevertheless, users are subject to undesired side effects majorly associated with tissue-specific a...

journal_title：Steroids

authors： Machek SB,Cardaci TD,Wilburn DT,Willoughby DS

更新日期：2020-12-01 00:00:00

abstract：:Progesterone and its polar metabolite(s) trigger the meiotic divisions in the amphibian oocyte through a non-genomic signaling system at the plasma membrane. Published site-directed mutagenesis studies of ouabain binding and progesterone-ouabain competition studies indicate that progesterone binds to a 23 amino acid e...

journal_title：Steroids

authors： Morrill GA,Kostellow AB,Askari A

更新日期：2012-09-01 00:00:00

abstract：:The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3). ...

journal_title：Steroids

authors： Brosa C,Puig R,Comas X,Fernández C

更新日期：1996-09-01 00:00:00

abstract：:Carbenoxolone potentiates the mineralocorticoid activity of endogenous glucocorticoid hormones by inhibiting the enzyme 11 beta-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone to inactive 11-oxo-derivatives. We addressed the question of whether glucocorticoid activity is also affected by carbe...

journal_title：Steroids

authors： Soro A,Panarelli M,Holloway CD,Fraser R,Kenyon CJ

更新日期：1997-04-01 00:00:00

abstract：:A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route...

journal_title：Steroids

authors： Wang J,Gu XZ,He LM,Li CC,Qiu WW

更新日期：2020-05-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), the enzyme that catalyzes the conversion of biologically active glucocorticoids to their inactive metabolites, was shown to be located exclusively in Leydig cells of the rat testis, and its appearance was associated with the developmental rise in testosterone. Thus, ...

journal_title：Steroids

authors： Nacharaju VL,Muneyyirci-Delale O,Khan N

更新日期：1997-03-01 00:00:00

abstract：:The sterol mixture of the southern Japan's soft coral, Sarcophyton glaucum, was found to contain 11 sterols including a novel sterol, 23,24 xi-dimethylcholesta-5,22-dien-3 beta-ol and a new diunsaturated C29 sterol. 22,23-Dihydrobrassicasterol and gorgosterol were the major components in free- and esterified sterols r...

journal_title：Steroids

authors： Kobayashi M,Tomioka A,Mitsuhashi H

更新日期：1979-09-01 00:00:00

abstract：:A variety of compounds, including the selective estrogen receptor (ER) modulators tamoxifen and raloxifene, phytoestrogens such as genistein, and xenoestrogens such as bisphenol, bind to the estrogen receptor and elicit biological responses. Structural studies have linked the altered activity of compounds such as 4-hy...

journal_title：Steroids

authors： Brooks SC,Skafar DF

更新日期：2004-06-01 00:00:00

abstract：:The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...

journal_title：Steroids

authors： Pérez-de-Heredia F,Sánchez J,Priego T,Nicolás F,Portillo Mdel P,Palou A,Zamora S,Garaulet M

更新日期：2008-10-01 00:00:00

abstract：:Hydroxycitric acid (HCA), a dietary-derived weight loss supplement, competitively inhibits ATP citrate lyase (ACLY). Tamoxifen (TAM) is the most frequently used therapy for estrogen receptor (ER)-positive breast cancer patients, but its application was restricted due to efficacy related issues. Lipid metabolic reprogr...

journal_title：Steroids

authors： Ismail A,Doghish AS,E M Elsadek B,Salama SA,Mariee AD

更新日期：2020-08-01 00:00:00

abstract：:The in vivo retention of 3-H-testosterone, dihydrotestosterone (DHT), 3alpha-androstanediol (3alpha-DIOL), 3beta-DIOL, androstenedione, progesterone and cortisol by renal cytoplasm and nuclei of male and female mice was studied. Testosterone was the major androgen isolated from cytoplasm and nuclei following testoster...

journal_title：Steroids

authors： Bullock LP,Bardin CW

更新日期：1975-01-01 00:00:00

abstract：:Inhibitors of estrogen 2-hydroxylase can be utilized in studying the kinetics of this cytochrome P450 enzyme complex and in elucidating the structural requirements of the active site. The conversion of estrogens to 2-hydroxyestrogens in rat liver microsomal preparations was examined using two radiotracer assays, the c...

journal_title：Steroids

authors： Brueggemeier RW,Kimball JG

更新日期：1983-07-01 00:00:00

abstract：:The peripheral conversion of testosterone (T) into androstenedione (delta 4) and dihydrotestosterone (DHT) were studied in pregnant (days 32, 48 and 67 post coitum) and non-pregnant anesthetized guinea-pigs by constant intravenous infusion of tritium labeled T. Endogenous levels were measured by radioimmunoassay, and ...

journal_title：Steroids

authors： Despres G,Rigaudière N

更新日期：1983-08-01 00:00:00

abstract：:We report the synthesis of 10 novel steroids obtained from 3 beta, 15 beta-diacetoxy-17 alpha-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-1,2,6,...

journal_title：Steroids

authors： Reeder AY,Joannou GE

更新日期：1997-02-01 00:00:00

abstract：:Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...

journal_title：Steroids

authors： Chien EJ,Hsu CH,Chang VH,Lin EP,Kuo TP,Chien CH,Lin HY

更新日期：2016-07-01 00:00:00

abstract：:Metandienone is one of the most frequently detected anabolic androgenic steroids in sports drug testing. Metandienone misuse is commonly detected by monitoring different metabolites excreted free or conjugated with glucuronic acid using gas chromatography mass spectrometry (GC-MS) and liquid chromatography tandem mass...

journal_title：Steroids

authors： Gómez C,Pozo OJ,Garrostas L,Segura J,Ventura R

更新日期：2013-12-11 00:00:00

abstract：:In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated. The triazene prepared from the amino-clomiphene...

journal_title：Steroids

authors： Gazit A,Livshitz T,Shani J

更新日期：1986-07-01 00:00:00

abstract：:Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...

journal_title：Steroids

authors： Haajanen K,Botting NP

更新日期：2006-03-01 00:00:00

abstract：:Ten sex steroids were measured in the peripheral serum and ovarian follicular fluid of female pigs with or without cystic ovarian disease. In general, progestin, especially progesterone, accumulated excessively in the fluid contained in cystic compared with normal follicles. Nonluteinized cystic follicles contained up...

journal_title：Steroids

authors： Babalola GO,Shapiro BH

更新日期：1990-07-01 00:00:00

abstract：:Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. In the present study, we showed that deltonin inhibited the proliferation of primary cultured human umbilical vein endothelial cells (HUVECs) in vitro; notably, ...

journal_title：Steroids

authors： Tong Q,Zhao Q,Qing Y,Hu X,Jiang L,Wu X

更新日期：2015-04-01 00:00:00

abstract：:Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...

journal_title：Steroids

authors： Li H,Xie H,Fu M,Li W,Guo B,Ding Y,Wang Q

更新日期：2013-02-01 00:00:00

abstract：:Using beta-sitosterol as a starting material, (6E)-hydroximino-24-ethylcholest-4-en-3-one (1), a natural steroidal oxime from Cinachyrella alloclada and C. apion, was synthesized in four steps with a high overall yield. First, beta-sitosterol (5a) is transformed into the corresponding 24-ethylcholest-4-en-3,6-dione (6...

journal_title：Steroids

authors： Cui J,Huang L,Fan L,Zhou A

更新日期：2008-03-01 00:00:00

abstract：:The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...

journal_title：Steroids

authors： Solaja BA,Dermanović M,Lim DM,Paik YK,Tinant B,Declerq JP

更新日期：1997-11-01 00:00:00

abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...

journal_title：Steroids

authors： Zheng QC,Chen GD,Kong MZ,Li GQ,Cui JY,Li XX,Wu ZY,Guo LD,Cen YZ,Zheng YZ,Gao H

更新日期：2013-09-01 00:00:00

abstract：:In the present study the possible dual effects of adenosine as substrate and adenosine receptor agonist in rat granulosa cells, cumulus-oocyte complexes, luteal cells and ovarian membranes are discussed. Adenosine is an indispensable compound in cell energy metabolism, as precursor to cofactors, second messenger and n...

journal_title：Steroids

authors： Billig H,Rosberg S,Johanson C,Ahrén K

更新日期：1989-11-01 00:00:00

abstract：:Radioimmunoassay (RIA) for testosterone (T) in unchromatographed plasma extracts from ATD-treated rats gave spuriously high values for T. Cross-reaction and chromatographic studies subsequently showed that ATD and, to a much greater extent, its metabolite(s) were responsible for this overestimation. Celite column chro...

journal_title：Steroids

authors： Donaldson MD,Forest MG

更新日期：1980-12-01 00:00:00

abstract：:Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The result...

journal_title：Steroids

authors： Cui J,Pang L,Wei M,Gan C,Liu D,Yuan H,Huang Y

更新日期：2018-12-01 00:00:00

abstract：:The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were foun...

journal_title：Steroids

authors： Cohen BI,Kuramoto T,Rothschild MA,Graham R,Mosbach EH

更新日期：1977-10-01 00:00:00

abstract：:Based on histological criteria, Kingsley and Bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. In contrats, Kennedy (4) found in estrogen-pretreated rats that ...

journal_title：Steroids

authors： Kennedy TG,Armstrong DT

更新日期：1976-03-01 00:00:00