A novel steroidal spin label for membrane structure studies: synthesis and applications.

abstract：:The sterol mixture of the southern Japan's soft coral, Sarcophyton glaucum, was found to contain 11 sterols including a novel sterol, 23,24 xi-dimethylcholesta-5,22-dien-3 beta-ol and a new diunsaturated C29 sterol. 22,23-Dihydrobrassicasterol and gorgosterol were the major components in free- and esterified sterols r...

journal_title：Steroids

authors： Kobayashi M,Tomioka A,Mitsuhashi H

更新日期：1979-09-01 00:00:00

abstract：:The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employe...

journal_title：Steroids

authors： Rao PN,Khan AH,Moore PH Jr

更新日期：1977-02-01 00:00:00

abstract：:Because diffusion of testosterone (T) into the salivary gland is thought to be largely limited to the free, biologically active fraction, salivary testosterone is expected to provide a better measure of testosterone bioavailability in the body than is plasma testosterone. Matched saliva and blood spot samples were col...

journal_title：Steroids

authors： Rilling JK,Worthman CM,Campbell BC,Stallings JF,Mbizva M

更新日期：1996-06-01 00:00:00

abstract：:The reduction of 17-oxosteroids to 17β-hydroxysteroids is one of the important transformations for the preparation of many steroidal drugs and intermediates. The strain Zygowilliopsis sp. WY7905 was found to catalyze the reduction of C-17 carbonyl group of androst-4-ene-3,17-dione (AD) to give testosterone (TS) as the...

journal_title：Steroids

authors： Liu Y,Wang Y,Chen X,Wu Q,Wang M,Zhu D,Ma Y

更新日期：2017-02-01 00:00:00

abstract：:The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

journal_title：Steroids

authors： Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

更新日期：2011-09-01 00:00:00

abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...

journal_title：Steroids

authors： Shutt DA,Shearman RP,Lyneham RC,Clarke AH,McMahon GR,Goh P

更新日期：1975-09-01 00:00:00

abstract：:Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...

journal_title：Steroids

authors： Kelly MJ,Rønnekleiv OK,Ibrahim N,Lagrange AH,Wagner EJ

更新日期：2002-05-01 00:00:00

abstract：:Brassinosteroids (BRs) are an important class of plant hormones with a multitude of functions. They have been intensively investigated for their biosynthesis, distribution and physiological functions. The aim of this study was to examine possible effects of BRs on the plant plasma membrane cation conductances and Ca(2...

journal_title：Steroids

authors： Straltsova D,Chykun P,Subramaniam S,Sosan A,Kolbanov D,Sokolik A,Demidchik V

更新日期：2015-05-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (HSD) was studied in endometrium removed surgically from intact female monkeys in the luteal phase of the menstrual cycle. Also castrated monkeys (N=20) implanted with estradiol (E2) and progesterone (P) in silastic capsules were used to investigate the hormonal dependence of this ...

journal_title：Steroids

authors： Kreitmann O,Kreitmann-Gimbal B,Bayard F,Hodgen GD

更新日期：1979-01-01 00:00:00

abstract：:Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...

journal_title：Steroids

authors： Haajanen K,Botting NP

更新日期：2006-03-01 00:00:00

abstract：:This study describes a new approach using stable isotope methodology in evaluating 11beta-HSD activities in vivo based on urinary excretion of cortisol, cortisone, and their A-ring reduced metabolites. The method involved the measurement of deuterium-labeled cortisol and its deuterium-labeled metabolites by GC/MS simu...

journal_title：Steroids

authors： Kasuya Y,Shibasaki H,Furuta T

更新日期：2000-02-01 00:00:00

abstract：:The effect of sodium intake on the aldosterone metabolic clearance rate (MCR) was examined in 5 normal subjects. Measurements were made under conditions where dietary sodium ranged from 10 to 1500 meq/day. There were no consistent changes in MCR over these extremes of sodium intake, and the plasma level of aldosterone...

journal_title：Steroids

authors： Pratt JH,Luft FC,Parkinson CA,Rankin LI

更新日期：1981-01-01 00:00:00

abstract：:The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior b...

journal_title：Steroids

authors： Rao PN,Cessac JW,Boyd JW,Hanson AD,Shah J

更新日期：2008-02-01 00:00:00

abstract：:The compounds named in the title have been synthesized from the di-(ethylene ketal) of 21-hydroxy-3,20-dioxo-19-norpregn-5-ene-18, 11 beta-lactone and its 5(10)-ene isomer. Reduction of this mixture 1 with sodium aluminum bis-(methoxyethoxy)hydride furnished the 11 beta, 18, 21-triol 2a. Conversion to the 18,21-diacet...

journal_title：Steroids

authors： Harnik M,Kashman Y,Carmely S,Cojocaru M,Dale SL,Holbrook MM,Melby JC

更新日期：1986-01-01 00:00:00

abstract：:Synthesis of 7-aryl/allyl-substituted androstene derivatives 3a through 3g has been carried out by Grignard reaction on 3 beta,17 beta-diacetoxyandrost-5-en-7-one (2) with aryl/allyl magnesium bromide. Isomeric mixture of products 3b and 3c/3e and 3f/3h was separated by column chromatography. Stereochemical assignment...

journal_title：Steroids

authors： Grover A,Dwivedy I,Singh AK,Ray S,Singh MM,Kamboj VP

更新日期：1991-09-01 00:00:00

abstract：:A series of steroidal and nonsteroidal Michael acceptors that represent reaction products for 3 alpha-hydroxysteroid dehydrogenase were synthesized and evaluated as potential enzyme-generated inactivators. Introduction of exocyclic olefins either at C-2 or C-6 produced inhibitors with high affinity for the enzyme (0.0...

journal_title：Steroids

authors： Penning TM,Thronton R,Ricigliano JW

更新日期：1991-08-01 00:00:00

abstract：:Human keratinocytes convert 25(OH)D(3) to hormonally active 1alpha,25(OH)(2)D(3) and respond to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1alpha,25(OH)(2)D(3) are short-lived. 1alpha,25(OH)(2)D(3) induces 24-hydroxylase (CYP24) that rapidly metabolizes the hormone, yi...

journal_title：Steroids

authors： Schuster I,Egger H,Bikle D,Herzig G,Reddy GS,Stuetz A,Stuetz P,Vorisek G

更新日期：2001-03-01 00:00:00

abstract：:Glucocorticoids (GCs) are essential steroid hormones that regulate numerous metabolic and homeostatic functions in almost all physiological systems. Synthetic glucocorticoids are among the most commonly prescribed drugs for the treatment of various conditions including autoimmune, allergic and inflammatory diseases. G...

journal_title：Steroids

authors： Sulaiman RS,Kadmiel M,Cidlowski JA

更新日期：2018-05-01 00:00:00

abstract：:The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membran...

journal_title：Steroids

authors： Castelnovo LF,Magnaghi V,Thomas P

更新日期：2019-02-01 00:00:00

abstract：:Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3...

journal_title：Steroids

authors： Halperin G,Gatt S

更新日期：1980-01-01 00:00:00

abstract：:It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...

journal_title：Steroids

authors： Shany S,Levy Y,Lahav-Cohen M

更新日期：2001-03-01 00:00:00

abstract：:Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. In the present study, we showed that deltonin inhibited the proliferation of primary cultured human umbilical vein endothelial cells (HUVECs) in vitro; notably, ...

journal_title：Steroids

authors： Tong Q,Zhao Q,Qing Y,Hu X,Jiang L,Wu X

更新日期：2015-04-01 00:00:00

abstract：:Corticosteroids were used normally as anti-inflammatory drugs. However, in some area certain corticosteroids might be illegally used as growth promoting agent in feed, and as prohibited doping substances in game and sport for human or/and animal performance-enhancing. Synthesized structural similar corticosteroids wer...

journal_title：Steroids

authors： Chen SY,Fang M,Lin YT,Tsai CF,Cheng HF,Wang DY

更新日期：2021-01-01 00:00:00

abstract：:The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were foun...

journal_title：Steroids

authors： Cohen BI,Kuramoto T,Rothschild MA,Graham R,Mosbach EH

更新日期：1977-10-01 00:00:00

abstract：:C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...

journal_title：Steroids

authors： Sholl SA

更新日期：1981-08-01 00:00:00

abstract：:Cholesterol side-chain cleavage (CSCC) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. CSCC activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin whic...

journal_title：Steroids

authors： Sholl SA,Wolf RC,Colás AE

更新日期：1977-02-01 00:00:00

abstract：:(24R and 24S)-5beta-cholestane-3alpha,7alpha,24,25-tetrols were prepared by osmium tetroxide oxidation of 5beta-cholest-24-ene-3alpha,7alpha-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and ...

journal_title：Steroids

authors： Batta AK,Dayal B,Tint GS,Shefer S,Toome V,Salen G,Mosbach EH

更新日期：1978-01-01 00:00:00

abstract：:The synthesis of seco-D and D-homo digitalis derivatives, from the carda-14,20(22)-dienolide 1, is described. Selective ozonolysis gave the seco-D 14-ketoaldehyde 2a. Modification of the two carbonyl groups and of the alpha, beta-unsaturated lactone ring of the seco-D 14-ketoaldehyde 2a allowed preparation of derivati...

journal_title：Steroids

authors： Gobbini M,Benicchio A,Marazzi G,Padoani G,Torri M,Melloni P

更新日期：1996-10-01 00:00:00

abstract：:The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was t...

journal_title：Steroids

authors： D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UM

更新日期：2013-12-11 00:00:00

abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...

journal_title：Steroids

authors： Schneider C,Schöler HF,Schneider RJ

更新日期：2004-04-01 00:00:00