Abstract:
:The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were found: II, 24-nor-5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol, III, 24-nor-5beta-cholestane-3alpha,7alpha,12alpha,25,26-pentol; IV, 24-nor-5beta-cholest-23-ene-3alpha,7alpha,12alpha-triol; and V, 24-nor-5beta-cholest-23-ene-3alpha,7alpha-diol. In the bile acid fraction, 24-nor-cholic acid and 3alpha,7alpha,12alpha-trihydroxy-24-nor-5beta-cholest-23-en-26-oic acid were present. The perfused nor-triol was not resistant to 12alpha-hydroxylation.
journal_name
Steroidsjournal_title
Steroidsauthors
Cohen BI,Kuramoto T,Rothschild MA,Graham R,Mosbach EHdoi
10.1016/0039-128x(77)90099-xsubject
Has Abstractpub_date
1977-10-01 00:00:00pages
541-59issue
4eissn
0039-128Xissn
1878-5867pii
0039-128X(77)90099-Xjournal_volume
30pub_type
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