Abstract:
:Circulating human lymphocytes are known to contain specific glucocorticoid receptors. Using a competitive binding whole cell assay, we have examined the binding of [3H] dexamethasone to peripheral lymphocytes of normal male subjects. Lymphocytes were found to contain 2000-10000 glucocorticoid receptor sites/cell and the Kd value was in the range of 0.5-9 X 10(-9) M. The number and affinity of glucocorticoid receptors did not change throughout a 1-year observation time. In contrast, there was a significant diurnal variation in receptor content (38% higher at 11 p.m. than at 8 a.m.), while receptor affinity did not change.
journal_name
Steroidsjournal_title
Steroidsauthors
Schlaghecke R,Kley HKdoi
10.1016/0039-128x(86)90098-xsubject
Has Abstractpub_date
1986-04-01 00:00:00pages
287-94issue
4-5eissn
0039-128Xissn
1878-5867pii
0039-128X(86)90098-Xjournal_volume
47pub_type
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