Evaluation impact of long-term usage of inhaled fluticasone propionate on ocular functions in children with asthma.

abstract：:The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and...

journal_title：Steroids

authors： Broess AI,van Vliet NP,Groen MB,Hamersma H

更新日期：1992-11-01 00:00:00

abstract：:Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...

journal_title：Steroids

authors： Kelly MJ,Rønnekleiv OK,Ibrahim N,Lagrange AH,Wagner EJ

更新日期：2002-05-01 00:00:00

abstract：:The first convenient chemical synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione is reported. Androsta-4,6-diene3, 17-dione was converted into its 6alpha, 7alpha-epoxy-derivative; reduction of the epoxide with aluminum amalgam gave 7alpha-hydroxyandrost-4-ene-3,17-dione. This reducing agent is more efficient than chr...

journal_title：Steroids

authors： Hossain AM,Kirk DN,Mitra G

更新日期：1976-05-01 00:00:00

abstract：:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...

journal_title：Steroids

authors： Wang C,Zhao M,Yang J,Peng S

更新日期：2001-11-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), the enzyme that catalyzes the conversion of biologically active glucocorticoids to their inactive metabolites, was shown to be located exclusively in Leydig cells of the rat testis, and its appearance was associated with the developmental rise in testosterone. Thus, ...

journal_title：Steroids

authors： Nacharaju VL,Muneyyirci-Delale O,Khan N

更新日期：1997-03-01 00:00:00

abstract：:The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...

journal_title：Steroids

authors： Pérez-de-Heredia F,Sánchez J,Priego T,Nicolás F,Portillo Mdel P,Palou A,Zamora S,Garaulet M

更新日期：2008-10-01 00:00:00

abstract：:As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...

journal_title：Steroids

authors： Mukherjee D,Engel CR

更新日期：1979-11-01 00:00:00

abstract：:The high concentrations of dehydroepiandrosterone sulfate and pregnenolone sulfate in the mammalian brain, despite the blood-brain barrier's impermeability to these compounds, and the apparent independence of these concentrations from those in plasma prompted us to investigate whether enzymatic sulfation of dehydroepi...

journal_title：Steroids

authors： Rajkowski KM,Robel P,Baulieu EE

更新日期：1997-05-01 00:00:00

abstract：:To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...

journal_title：Steroids

authors： Vesper HW,Botelho JC,Vidal ML,Rahmani Y,Thienpont LM,Caudill SP

更新日期：2014-04-01 00:00:00

abstract：:Plant lignans are currently being widely studied for their potential benefits for human health as their consumption has been correlated with lower risks for developing chronic diseases, such as breast cancer and coronary heart disease. However, studies of some classes of lignans, in particular the furofurans, are hamp...

journal_title：Steroids

authors： Haajanen K,Botting NP

更新日期：2006-03-01 00:00:00

abstract：:7-Oxo-dehydroepiandrosterone, which can be formed from dehydroepiandrosterone (DHEA) by several mammalian tissues, is more effective than its parent steroid as an inducer of thermogenic enzymes when administered to rats. Using the Morris water maze procedure, we tested DHEA and its 7-oxo-derivative for their ability t...

journal_title：Steroids

authors： Shi J,Schulze S,Lardy HA

更新日期：2000-03-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (HSD) was studied in endometrium removed surgically from intact female monkeys in the luteal phase of the menstrual cycle. Also castrated monkeys (N=20) implanted with estradiol (E2) and progesterone (P) in silastic capsules were used to investigate the hormonal dependence of this ...

journal_title：Steroids

authors： Kreitmann O,Kreitmann-Gimbal B,Bayard F,Hodgen GD

更新日期：1979-01-01 00:00:00

abstract：:Nuclear membrane bound testosterone 5 alpha-reductase solubilized in active form from human prostatic tissue by 0.5% n-octyl beta-D-glucopyranoside was purified by a four-step chromatographic procedure including DEAE-Trisacryl ion exchange, hydroxylapatite adsorption, testosterone-Sepharose affinity and Sepharose 4B g...

journal_title：Steroids

authors： Quemener E,Amet Y,di Stefano S,Fournier G,Floch HH,Abalain JH

更新日期：1994-12-01 00:00:00

abstract：:We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3 beta, 22-diol-3 beta-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3 beta-acetate 3 and (E) 22-dehydrocholest-5-en-3 beta-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixture of the ...

journal_title：Steroids

authors： Gill HS,Londowski JM,Corradino RA,Kumar R

更新日期：1986-07-01 00:00:00

abstract：:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h)...

journal_title：Steroids

authors： Branchaud CL,Lipowski L,Dhanani B,Goodyer CG,Lefebvre Y

更新日期：1986-04-01 00:00:00

abstract：:Recent studies have suggested that progestins play a role in the etiology of breast cancer; however, the mechanisms by which progestins promote tumor formation/progression have not been defined. Progestin action, in target tissues such as the breast, is mediated by the progesterone receptor (PR). PR signaling is compl...

journal_title：Steroids

authors： Treviño LS,Bingman WE 3rd,Edwards DP,Nl W

更新日期：2013-06-01 00:00:00

abstract：:15alpha-Hydroxydehydroisoandrosterone and 15alpha-hydroxypregnenolone were isolated from hydrolyzed extracts of human late pregnancy urine and identified by means of the isotope dilution technique. In two separate determinations the excretion rate of 15alpha-hydroxydehydroisoandrosterone was found to be 1.7 and 3.2 mi...

journal_title：Steroids

authors： Stanczyk FZ,Stern M,Solomon S

更新日期：1978-05-01 00:00:00

abstract：:When day 6 rabbit blastocysts were cultured (3 embryos/mL) in medium 199 containing 3.68 microM estradiol-17 beta (E2), 40% of E2 was metabolized in 24 h, at a rate of 18 pmol/embryo(b)/h, yielding 4 major metabolite fractions. Two of them were identified to be estrogen glucosides: 17 beta-hydroxyestra-1,3,5(10)-trien...

journal_title：Steroids

authors： Wu JT,Williams KI

更新日期：1989-10-01 00:00:00

abstract：:During our studies of the hepatic androgen receptor in cynomolgus monkeys, tritiated mibolerone +/- a 200-fold excess of unlabeled mibolerone has been used to determine specific binding in cytosol. During time-course studies, high-capacity, unsaturable binding of [3H]mibolerone was noted after short-term incubations (...

journal_title：Steroids

authors： Koritnik DR,Marschke KB,Koshy A

更新日期：1995-11-01 00:00:00

abstract：:The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...

journal_title：Steroids

authors： Zomer G,Stavenuiter JF

更新日期：1990-10-01 00:00:00

abstract：:The mechanistic aspects of the alkali-catalyzed rearrangement of 16alpha-hydroxy-17-keto steroid 1 to 17beta-hydroxy-16-keto steroid 2 are elucidated by use of (18)O- and deuterium-labeling experiments. The (18)O-labeling experiments refute the gem-hydration-quasi-diaxial dehydration mechanism for the rearrangement pr...

journal_title：Steroids

authors： Numazawa M,Nagaoka M,Matsuzaki H,Yamashita K,Komatsu S,Osawa Y

更新日期：2008-09-01 00:00:00

abstract：:Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2)...

journal_title：Steroids

authors： Kornel L,Miyabo S

更新日期：1975-06-01 00:00:00

abstract：:Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence...

journal_title：Steroids

authors： Mohamed NR,Elmegeed GA,Abd-ElMalek HA,Younis M

更新日期：2005-03-01 00:00:00

abstract：:Osteoblasts are a main target for the steroid 1alpha,25(OH)2-Vitamin D3 (1,25D3), where a major outcome is the modulation of the bone remodeling process. 1,25D3 deficiency leads to clinical disorders such as osteomalacia and osteoporosis, characterized by a state of insufficiently calcified tissue and bone loss, respe...

journal_title：Steroids

authors： Zanello LP,Norman AW

更新日期：2004-08-01 00:00:00

abstract：:A simplified, non-chromatographic method for aldosterone-gamma-lactone (2) radio-immunoassay is described, using a high titer aldosterone-gamma-lactone antibody. This method takes six working hours for completion; the blanks are below the sensitivity of the assay (0-10 pg), and the intra and interassay coefficient of ...

journal_title：Steroids

authors： Antunes JR,Dale SL,Melby JC

更新日期：1976-11-01 00:00:00

abstract：:In humans, the onset of adrenache has been found to occur with the appearance of the zona reticularis, the inner zone of the adrenal cortex. Since an increase in the volume of adrenal cortex during maturation in the guinea pig has been associated with the growth of the zona reticularis, we were interested in investiga...

journal_title：Steroids

authors： Bélanger B,Caron S,Boudou P,Fiet J,Bélanger A

更新日期：1992-02-01 00:00:00

abstract：:(25S)-3-Oxocholesta-1,4-dien-26-oic acid (1) and a new (25S)-18-acetoxy-3-oxocholesta-1,4-dien-26-oic acid (2) were isolated from a soft coral Minabea sp. (cf. aldersladei) collected in North Sulawesi, Indonesia, together with two known cholic-acid-type compounds, 3-oxochol-1,4-dien-24-oic acid (3) and 3-oxochol-4-en-...

journal_title：Steroids

authors： Wang W,Lee JS,Nakazawa T,Ukai K,Mangindaan RE,Wewengkang DS,Rotinsulu H,Kobayashi H,Tsukamoto S,Namikoshi M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Serum progesterone (P) rises after ovulation in the luteinisation process. OBJECTIVE:To identify an accurate progesterone threshold to confirm ovulation in the assessment of a woman's fertility. METHODS:In a secondary analysis of an observational European multicentre study, this study included 107 women ov...

journal_title：Steroids

authors： Leiva R,Bouchard T,Boehringer H,Abulla S,Ecochard R

更新日期：2015-09-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of plasma steroid-binding proteins on androgen metabolism in intact leukocytes prepared from normal male and female blood samples. Leukocyte preparations were incubated for 24 h at 37 degrees C with either labeled or unlabeled testosterone (T), 5 alpha-dihydro...

journal_title：Steroids

authors： Déchaud H,Goujon R,Claustrat F,Boucherat M,Pugeat M

更新日期：1995-02-01 00:00:00