Abstract:
:The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and 17 beta-hydroxy-12-methylene-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn- 3-one (38) were obtained in racemic form by total synthesis; they were shown to lack progestagenic activity.
journal_name
Steroidsjournal_title
Steroidsauthors
Broess AI,van Vliet NP,Groen MB,Hamersma Hdoi
10.1016/0039-128x(92)90020-asubject
Has Abstractpub_date
1992-11-01 00:00:00pages
514-21issue
11eissn
0039-128Xissn
1878-5867pii
0039-128X(92)90020-Ajournal_volume
57pub_type
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