Abstract:
:A trisulfated derivative of 24,25,26,26-tetramethyl-5 alpha-cholest-23E-ene-2 alpha, 3 beta, 6 alpha-triol (sokotrasterol sulfate) has been isolated from the sponge Halichondriidae gen. sp., collected near Sokotra Island (Arabian Sea), and its structure has been elucidated. The side chain of the new steroid involves a "normal" alkylation at C-24 and the unprecedented addition of two extra methyl groups at C-26 and one extra methyl group at C-25. A free sterol fraction contained only 24-isopropyl-5-cholesten-3 beta-ol and 24-isopropyl-5, 22E-cholestadien-3 beta-ol. 24-Isopropyl-5, 22E-cholestadien-3 beta-ol as sole monohydroxy sterol and halistanol sulfate as major polyhydroxylated steroid derivative have been detected in Halichondria sp., a Madagascar sponge.
journal_name
Steroidsjournal_title
Steroidsauthors
Makarieva TN,Shubina LK,Kalinovsky AI,Stonik VA,Elyakov GBdoi
10.1016/0039-128x(83)90039-9subject
Has Abstractpub_date
1983-09-01 00:00:00pages
267-81issue
3eissn
0039-128Xissn
1878-5867pii
0039-128X(83)90039-9journal_volume
42pub_type
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