Differential binding of dexamethasone to ammonium sulfate precipitates of human adipose tissue cytosols.

abstract：:A time course study to measure adrenal cortical function was undertaken for the period prior to the development of hypertension until the onset of hypertension in the adrenal-regeneration hypertension (ARH) model. Quiescent rat kills were used so that all adrenal cortical parameters investigated would reflect basal or...

journal_title：Steroids

authors： Bergon L,Gallant S,Brownie AC

更新日期：1975-03-01 00:00:00

abstract：:In addition to using radioimmunoassays for the determination of estrogens and other steroids, the possibility of using mass fragmentography for analysis was investigated. t-Butyldimethylsilyl chloride was selected as a reagent for derivatisation because it forms rather stable silylethers. In all the mass-spectra obrai...

journal_title：Steroids

authors： Ballhorn L,Mueller WF,Korte F

更新日期：1979-04-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of plasma steroid-binding proteins on androgen metabolism in intact leukocytes prepared from normal male and female blood samples. Leukocyte preparations were incubated for 24 h at 37 degrees C with either labeled or unlabeled testosterone (T), 5 alpha-dihydro...

journal_title：Steroids

authors： Déchaud H,Goujon R,Claustrat F,Boucherat M,Pugeat M

更新日期：1995-02-01 00:00:00

abstract：:We describe the development of a serum chlormadinone acetate (CMA) time-resolved fluoroimmunoassay (TR-FIA). We prepared haptens (3-CMO-chlormadinone acetate and 6-chloropregna-4,6-dien-17,20-diol-3-one-20-hemisuccinate), biotinylated tracers (3(biotinylaminopropylamido) 3-CMO-chlormadinone acetate and 3-(6-chloropreg...

journal_title：Steroids

authors： Fiet J,Giton F,Auzerie J,Galons H

更新日期：2002-12-01 00:00:00

abstract：:Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sources. In this work, we propose the use of the 1H NMR technique to evaluate formul...

journal_title：Steroids

authors： Ribeiro MVM,Boralle N,Felippe LG,Pezza HR,Pezza L

更新日期：2018-10-01 00:00:00

abstract：:Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...

journal_title：Steroids

authors： Ekhato IV,Hurley T,Lovdahl M,Revitte TJ,Guo L,Huang Y,Clipper S,Colson C

更新日期：2002-03-01 00:00:00

abstract：:Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...

journal_title：Steroids

authors： Hanekamp EE,Gielen SC,van Oosterhoud SA,Burger CW,Grootegoed JA,Huikeshoven FJ,Blok LJ

更新日期：2003-11-01 00:00:00

abstract：:Bile acid conjugates are found in human breast cyst fluid in average concentrations about 50-fold greater than those in blood. Because epidemiologic studies have linked colon and breast cancer and aberrant bile acid profiles are associated with colon cancer risk, we decided to study the influence of bile acid conjugat...

journal_title：Steroids

authors： Raju U,Katz J,Levitz M

更新日期：1997-10-01 00:00:00

abstract：:Estrogen results in the suppression of experimental allergic encephalomyelitis (EAE), a frequently used experimental animal model of multiple sclerosis (MS). The mechanism by which estrogen acts in diseases with an autoimmune background is less clear. Here, we used splenic dendritic cells (DC) from the Lewis rats EAE ...

journal_title：Steroids

authors： Xiao BG,Liu X,Link H

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of physiologic levels of androgens and their precursors in the regulation of body composition, energy and substrate metabolism and aerobic capacity in healthy, cycling, premenopausal women. EXPERIMENTAL:We evaluated 30 young (27±1 year) premenopausal, non-obese (23±0.5 kg/m(2)), normally...

journal_title：Steroids

authors： Keller JL,Casson PR,Toth MJ

更新日期：2011-11-01 00:00:00

abstract：:Fingernail clipping is expected to be a specimen for steroid testing, because it has several advantages over blood; i.e., noninvasive collection, ease of storage, portability and handling, and possibility for an assessment of the steroid status over a relatively long and retrospective time window. In this study, we ex...

journal_title：Steroids

authors： Higashi T,Yamagata K,Kato Y,Ogawa Y,Takano K,Nakaaze Y,Iriyama T,Min JZ,Ogawa S

更新日期：2016-05-01 00:00:00

abstract：:This study was designed to describe the time-course changes of catabolic proteins following muscle atrophy induced by 10 days of dexamethasone (DEX). Rats underwent DEX treatment for 1, 3, 5, 7 and 10 days. Body weight (BW) and lean mass were obtained using a dual energy X-ray absorptiometry (DEXA) scan. Muscle ringer...

journal_title：Steroids

authors： Macedo AG,Krug AL,Souza LM,Martuscelli AM,Constantino PB,Zago AS,Rush JW,Santos CF,Amaral SL

更新日期：2016-03-01 00:00:00

abstract：:A direct competitive heterologous enzyme-linked immunosorbent assay (ELISA) was developed and validated to determine follicular fluid estradiol levels of different antral follicular sizes (small, medium, and large) obtained from the ovaries of heifers in the follicular phase of the estrous cycle. Polyclonal antiestrad...

journal_title：Steroids

authors： Silván G,Illera JC,Illera M

更新日期：1993-07-01 00:00:00

abstract：:Glucocorticoids are important regulators of metabolism and immune function. Synthetic glucocorticoids are extensively used for immunosuppression/anti-inflammatory therapy. Since the glucocorticoid receptor (GR) is central to most hormone effects; its in vivo regulation will influence hormone/drug action. An alternativ...

journal_title：Steroids

authors： DuBois DC,Sukumaran S,Jusko WJ,Almon RR

更新日期：2013-02-01 00:00:00

abstract：:Steroid hormone is extensively used for transmitting variety of biological signals in organisms. Natural steroid hormone is synthesized from cholesterol in adrenal cortex and in sexual gland in vertebrates. Appropriately dosed synthetic steroid hormones can be used for medication. Despite their positive effects as med...

journal_title：Steroids

authors： Hori-Tanaka Y,Yura K,Takai-Igarashi T,Tanaka H

更新日期：2015-04-01 00:00:00

abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...

journal_title：Steroids

authors： McGinley R,Casey JH

更新日期：1979-02-01 00:00:00

abstract：:Bile acid derivatives, with and without C-3 sulfate groups, and having either the diazo- or halomethylketone moieties, have been synthesized in good yield and purity. The synthetic sequence, COOH leads to COC1 leads to COCHN2 leads to COCH2X, was used with deoxycholic and cholic acids, which requires carefully control...

journal_title：Steroids

authors： Fried AA,Petrow V,Lack L

更新日期：1979-08-01 00:00:00

abstract：:Estrogen is the key regulator of bone metabolism in both men and women. Menopause and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck and 10.6%, lumbar spine. Estradiol concentrations also predict fractures. Tot...

journal_title：Steroids

authors： Cauley JA

更新日期：2015-07-01 00:00:00

abstract：:The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were foun...

journal_title：Steroids

authors： Cohen BI,Kuramoto T,Rothschild MA,Graham R,Mosbach EH

更新日期：1977-10-01 00:00:00

abstract：:Estrogen plays a central role in the control of reproductive behaviour and in the regulation of neuroendocrine system. To elucidate the mechanism by which it controls the stress-modulated functions, it is important to understand how estrogenic effects are mediated. The distribution of estrogen receptor alpha (ERα) pro...

journal_title：Steroids

authors： Niranjan MK,Srivastava R

更新日期：2019-06-01 00:00:00

abstract：:A procedure utilizing co-chromatography and complementary antiserum comparisons was employed to assess the specificity of a cortisol radioimmunoassay for use in the chronically catheterized fetal sheep preparation. Complementary antiserum comparisons is a technique by which two different cortisol antisera, prepared fr...

journal_title：Steroids

authors： Magyar DM,Buster JE,Elsner CW,Nathanielsz PW,Oliveros R,Abraham GE

更新日期：1979-01-01 00:00:00

abstract：:A significant dose-response relationship between gonadotropin-releasing hormone (GnRH) and time to luteinizing hormone (LH) peak, peak serum LH and total serum LH was obtained in prepubertal Holstein heifers (28 weeks of age) (Experiment 1). For the second experiment, the effect of steroid feedback on the anterior pit...

journal_title：Steroids

authors： Swanson LV,McCarthy SK

更新日期：1986-02-01 00:00:00

abstract：:(24R and 24S)-5beta-cholestane-3alpha,7alpha,24,25-tetrols were prepared by osmium tetroxide oxidation of 5beta-cholest-24-ene-3alpha,7alpha-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and ...

journal_title：Steroids

authors： Batta AK,Dayal B,Tint GS,Shefer S,Toome V,Salen G,Mosbach EH

更新日期：1978-01-01 00:00:00

abstract：:A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 a...

journal_title：Steroids

authors： Jiang CS,Huang CG,Feng B,Li J,Gong JX,Kurtán T,Guo YW

更新日期：2010-12-12 00:00:00

abstract：:Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence...

journal_title：Steroids

authors： Mohamed NR,Elmegeed GA,Abd-ElMalek HA,Younis M

更新日期：2005-03-01 00:00:00

abstract：:An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The abso...

journal_title：Steroids

authors： Jia P,Wu X,Yu Y,Zhang G

更新日期：2009-02-01 00:00:00

abstract：:Five new C21 steroidal glycosides, namely, komarosides D (1), E (2), F (3), G (4), and H (5), along with two known C21 steroidal glycosides cynatratoside E (6) and hancoside A (7), were isolated from the ethanol extract of the roots of Cynanchum komarovii Al. Iljinski (Asclepiadaceae). Their structures were determined...

journal_title：Steroids

authors： Liqin W,Yuemao S,Xing X,Yuqing W,Jun Z

更新日期：2004-05-01 00:00:00

abstract：:Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...

journal_title：Steroids

authors： Leng T,Liu A,Wang Y,Chen X,Zhou S,Li Q,Zhu W,Zhou Y,Su X,Huang Y,Yin W,Qiu P,Hu H,Xiong ZG,Zhang J,Yan G

更新日期：2016-01-01 00:00:00

abstract：:Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. At 0 degrees C apparent equilibrium of ...

journal_title：Steroids

authors： Zakár T,Tóth M

更新日期：1977-12-01 00:00:00

abstract：:A partial synthesis of the title compound, 4'-(dimethylamino)-17 beta-hydroxy-17 alpha-(1-propynyl)benzo[12,12a]-11 alpha,18-cyclo-12a,12b- dihomo-13 alpha-estr-4-en-3-one 1, is reported. The key step in this synthesis represents an intramolecular alkenylaryl radical cyclization. Treatment of 18-[bromo-5-(dimethylamin...

journal_title：Steroids

authors： Ottow E,Beier S,Elger W,Fritzemeier KH,Neef G,Wiechert R

更新日期：1994-03-01 00:00:00