Synthesis and biological testing of 4'-(dimethylamino)-17 beta-hydroxy-17 alpha-(1-propynyl)benzo[12,12a]-11 alpha,18-cyclo-12a,12b-dihomo-13 alpha-estr-4-en-3-one: an interesting RU 38 486 analog.

abstract：:The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...

journal_title：Steroids

authors： Vázquez-Ramírez I,Macías-Alonso M,Arcos-Ramos RO,Ruíz-Pérez KM,Solano-Ramírez DO,Iglesias Arteaga MA

更新日期：2008-07-01 00:00:00

abstract：:Studies were carried out on the effect of oxygen tension on progesterone (P) accumulation in rat granulosa cell cultures. At 1-2% oxygen, basal, luteinizing hormone (LH)-stimulated, and follicle stimulating hormone (FSH)-stimulated P accumulations were 20, 18, and 11%, respectively, of P levels at 20% oxygen. Basal P ...

journal_title：Steroids

authors： Koos RD,Feiertag MA

更新日期：1989-11-01 00:00:00

abstract：:The formation of a horseradish peroxidase-testosterone conjugate for the enzyme-linked immunoassay of testosterone was investigated, using tritiated testosterone to follow the reaction. The formation of testosterone-3-(carboxymethyl) oxime-peroxidase by the mixed anhydride method was found to give a conjugate of high ...

journal_title：Steroids

authors： Rajkowski KM,Cittanova N,Desfosses B,Jayle MF

更新日期：1977-05-01 00:00:00

abstract：:A rapid, simple and sensitive high-performance liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous determination of six main steroidal saponins in Paris polyphylla in rat plasma. Ginsenoside Rg3 was selected as the internal standard (IS). Plasma samples were pretreated wi...

journal_title：Steroids

authors： Wang B,Ji S,Zhang H,Zhao L,Lv L,Li Y,Zhou G,Zhang G

更新日期：2013-12-11 00:00:00

abstract：:Inhibition of 5alpha-reduction of testosterone by an anti-androgen TSAA-291 (16beta-ethyl-17beta-hydroxy-4-estren-3-one) was studied in rat ventral prostates and the metabolic conversion of 3H-TSAA-291 was examined both in vitro and in vivo. In the in vitro experiment using nuclear 5alpha-reductase of the prostate, 5a...

journal_title：Steroids

authors： Sudo K,Yoshida K,Akinaga Y,Nakayama R

更新日期：1981-07-01 00:00:00

abstract：:Based on the fact that timosaponin A-III (TA-III) exhibits potent cytotoxic effects and has been considered as a potential anti-tumor agent, a range of novel sarsasapogenin derivatives 1, 2a-2g, 3, 4, 5, 6a-6g have been synthesized by a simple and facile synthetic route. The in vitro cytotoxic activity of these synthe...

journal_title：Steroids

authors： Yin Y,Zhao XC,Wang SJ,Gao PY,Li LZ,Ikejima T,Song SJ

更新日期：2015-01-01 00:00:00

abstract：:Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yie...

journal_title：Steroids

authors： Zhang BL,Zhang E,Pang LP,Song LX,Li YF,Yu B,Liu HM

更新日期：2013-12-11 00:00:00

abstract：:For the purpose of describing the pathway by which estrones are synthesized in the rhesus monkey (Macaca mulatta) corpus luteum (CL), CL were obtained during the midluteal phase of the menstrual cycle and fragments incubated with equimolar amounts of [7-3H]pregnenolone plus [4-14C]progesterone. Metabolites including 3...

journal_title：Steroids

authors： Sholl SA,Wolf RC

更新日期：1980-08-01 00:00:00

abstract：:A novel epoxy sterol isolated from the marine mollusc Planaxis sulcatus has been identified as 9 alpha,11 alpha-epoxycholest-7-ene-3 beta,5 alpha,6 beta-triol by spectrometric methods. ...

journal_title：Steroids

authors： Alam M,Sanduja R,Weinheimer AJ

更新日期：1988-07-01 00:00:00

abstract：:In this paper, we examine corticosteroid 11 beta-oxidation and 11-reduction as properties of the microsomal 11 beta-hydroxysteroid dehydrogenase complex in vertebrate livers. No hepatic activity in the oxidative direction (11 beta -dehydrogenase) was found in the frog, toad, mud puppy, shark, and bird livers. In contr...

journal_title：Steroids

authors： Monder C,Lakshmi V

更新日期：1988-11-01 00:00:00

abstract：:The condensation of O-substituted hydroxylamines with conjugated 3-oxo-4-en steroids results in a mixture of syn-anti configurations. Syn-anti ratios are influenced by sterical hindrance between the oximino substituents (e.g. O-benzyl) and the steroidal skeleton. Stereostructures and isomeric ratios were proved by det...

journal_title：Steroids

authors： Sohár P,Bodor A,Schwartz R

更新日期：1999-04-01 00:00:00

abstract：:The in vivo retention of 3-H-testosterone, dihydrotestosterone (DHT), 3alpha-androstanediol (3alpha-DIOL), 3beta-DIOL, androstenedione, progesterone and cortisol by renal cytoplasm and nuclei of male and female mice was studied. Testosterone was the major androgen isolated from cytoplasm and nuclei following testoster...

journal_title：Steroids

authors： Bullock LP,Bardin CW

更新日期：1975-01-01 00:00:00

abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...

journal_title：Steroids

authors： Zheng QC,Chen GD,Kong MZ,Li GQ,Cui JY,Li XX,Wu ZY,Guo LD,Cen YZ,Zheng YZ,Gao H

更新日期：2013-09-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is a multifunctional steroid with a broad range of biological effects in humans and animals. DHEA can be converted to multiple oxygenated metabolites in the brain and peripheral tissues. The mechanisms by which DHEA exerts its effects are not well understood. However, evidence that the ef...

journal_title：Steroids

authors： El Kihel L

更新日期：2012-01-01 00:00:00

abstract：:Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2)...

journal_title：Steroids

authors： Kornel L,Miyabo S

更新日期：1975-06-01 00:00:00

abstract：:Two isoforms of the androgen receptor (AR-A and AR-B), differing by a lack of the first 187 amino acids in the NH2-terminal transactivation domain of AR-A, are expressed in connective tissue and bone. Transient transfections of normal human osteoblastic cells (HOB) and of genital skin fibroblasts defective in AR (GSF-...

journal_title：Steroids

authors： Liegibel UM,Sommer U,Boercsoek I,Hilscher U,Bierhaus A,Schweikert HU,Nawroth P,Kasperk C

更新日期：2003-12-01 00:00:00

abstract：:Evaluation of sex steroids in cervical mucus was performed at different phases of spontaneous or clomiphene-citrate-induced ovulatory cycles. To this end, 11 women with normal ovulatory cycles and 9 subjects with polycystic ovary syndrome of comparable age and body mass index were investigated. Serum and cervical mucu...

journal_title：Steroids

authors： Adamopoulos DA,Kapolla N,Abrahamian A,Dessypris A,Nicopoulou S,Giannacodemos G

更新日期：2000-01-01 00:00:00

abstract：:Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depres...

journal_title：Steroids

authors： Bai Y,Song L,Dai G,Xu M,Zhu L,Zhang W,Jing W,Ju W

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Calcitriol, an active vitamin D metabolite, has a limited application in bone repair because of its undesirable hypercalcaemic action. However it has emerged that lithocholic acid (LCA) is a non-calcaemic vitamin D receptor ligand but whether this steroid can support osteoblast maturation has not be...

journal_title：Steroids

authors： Mansell JP,Shorez D,Farrar D,Nowghani M

更新日期：2009-11-01 00:00:00

abstract：:In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...

journal_title：Steroids

authors： Wuest F,Carlson KE,Katzenellenbogen JA

更新日期：2008-01-01 00:00:00

abstract：:A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trilliu...

journal_title：Steroids

authors： Shafiq-ur-Rahman,Ismail M,Shah MR,Adhikari A,Anis I,Ahmad MS,Khurram M

更新日期：2015-12-01 00:00:00

abstract：:The effect of cortisol and prostaglandin inhibitors on the growth and development of germinating mung bean, Vigna radiata L. Wilzek, cv. Jumbo was investigated. Cortisol, indomethacin, and a mixture of cortisol with aspirin, or benoxaprofen significantly increased radicle length and the number of lateral roots as comp...

journal_title：Steroids

authors： Gawienowski AM,Csernus KM,Simon JE,Craker LE

更新日期：1985-08-01 00:00:00

abstract：:Two new polyhydroxysteroids isihippurols A (1) and B (2) were isolated from the MeOH extract of the gorgonian Isis hippuris in addition to nine known steroids namely gorgosterol, 3alpha-acetoxy-24-methyl 11beta,18; 18,20beta; 22,25-triepoxy-5alpha-furostane, hippurin-1, 22-epi-hippuristanol, 22-epi-hippurin-1, 3-acety...

journal_title：Steroids

authors： Shen YC,Prakash CV,Chang YT

更新日期：2001-09-01 00:00:00

abstract：:Radioactive mestranol (ME) and/or ethynylestradiol (EE) were administered to women in Nigeria, Sri Lanka, and the USA, and the types and patterns of radioactive urinary conjugates examined by Sephadex LH-20 chromatography. There are no differences in the total excretion of urinary radioactivity over 3 days. Consistent...

journal_title：Steroids

authors： Williams MC,Goldzieher JW

更新日期：1980-09-01 00:00:00

abstract：:The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...

journal_title：Steroids

authors： Economou EV,Livaniou E,Evangelatos GP,Ithakissios DS

更新日期：1992-01-01 00:00:00

abstract：:Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...

journal_title：Steroids

authors： Caldwell JD,Jirikowski GF

更新日期：2014-03-01 00:00:00

abstract：:A virulent culture of Hymenoscyphus fraxineus, the causal agent of ash dieback, was investigated for its production of secondary metabolites in a 70 L batch fermentation. Chemical analysis of the mycelial extract by means of flash chromatography and preparative HPLC led to the isolation of a new ergostane-type steroid...

journal_title：Steroids

authors： Surup F,Halecker S,Nimtz M,Rodrigo S,Schulz B,Steinert M,Stadler M

更新日期：2018-07-01 00:00:00

abstract：:Fourteen esters (formate, acetate, propionate, butyrate, hexanoate, heptanoate, and benzoate) located at C-11 of 11 beta-hydroxyesterone and 11 beta-hydroxyestradiol-17 beta were synthesized and evaluated for uterotropic and gonadotropin release inhibition in rats, as well as their ability to displace (3H) estradiol-1...

journal_title：Steroids

authors： Segaloff A,Gabbard RB

更新日期：1984-01-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) controls the last step in the formation of all androgens and all estrogens. This crucial role of 17 beta-HSD is performed by at least five 17 beta-HSD isoenzymes having individual cell-specific expression, substrate specificity, regulation mechanisms, and reductive or...

journal_title：Steroids

authors： Labrie F,Luu-The V,Lin SX,Labrie C,Simard J,Breton R,Bélanger A

更新日期：1997-01-01 00:00:00

abstract：:The configurations at C-24 of 24-alkylsterols of six samples of Clerodendrum species (Verbenaceae) - the aerial parts of C. fragrans, C. inerme, C. infortunatum, C. scandens, and C. siphonanthus, and the seeds of C. infortunatum - were examined by NMR. All samples contained 24 beta-ethylsterols possessing a delta 25-b...

journal_title：Steroids

authors： Akihisa T,Matsubara Y,Ghosh P,Thakur S,Tamura T,Matsumoto T

更新日期：1989-03-01 00:00:00