Abstract:
:Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are actively involved in the uptake, intracellular transport, and possibly release of steroids from cells. This manuscript will also discuss our own findings that the steroid estradiol is taken up into the cell, as demonstrated by uptake of fluorescence labeled estradiol into Chinese hamster ovary (CHO) cells, and into the cytoplasm where it may have multiple actions that do not seem to involve the cell nucleus. This manuscript will focus mainly on events in two compartments of the cell, the plasma membrane and the cytoplasm.
journal_name
Steroidsjournal_title
Steroidsauthors
Caldwell JD,Jirikowski GFdoi
10.1016/j.steroids.2013.11.010subject
Has Abstractpub_date
2014-03-01 00:00:00pages
13-6eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00263-8journal_volume
81pub_type
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