Abstract:
:Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yields of these products are moderate to good and the reaction conditions are mild. The cytotoxicity of the synthesized compounds against EC-109(human esophageal carcinoma), EC-9706(human esophageal carcinoma), MGC-803(human gastric carcinoma) were investigated.
journal_name
Steroidsjournal_title
Steroidsauthors
Zhang BL,Zhang E,Pang LP,Song LX,Li YF,Yu B,Liu HMdoi
10.1016/j.steroids.2013.07.006subject
Has Abstractpub_date
2013-12-11 00:00:00pages
1200-8issue
12-13eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00168-2journal_volume
78pub_type
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