Abstract:
:We describe a novel steroid, which we have named "Ionotropin". Its unique features are: [1] it has 23 carbon atoms and [2] it is a phosphocholine ester. There are no other known mammalian steroids with either structural feature. Ionotropin cross reacts with digoxin-specific antibodies and may be the long-sought, endogenous, mammalian digoxin-like material (DLM). Using LC-MS, we identified three other phosphocholine steroids in serum. Two of these steroids also cross-react with digoxin specific antibodies. In adrenal extracts, we found both phosphocholine esters and corresponding phospho-ethanolamine steroid esters. There are no other known phosphoethanolamine steroid esters. Together, these 8 compounds define a biosynthetic pathway from 7-dehydropregnenolone to Ionotropin. Ionotropin may be the only steroid hormone not synthesized with cholesterol as a precursor. Finally, we propose that Ionotropin serves as the endogenous potassium sparing hormone. Ionotropin provides a new understanding of renal, cardiac, gonadal and placental function.
journal_name
Steroidsjournal_title
Steroidsauthors
Chasalow F,Pierce-Cohen Ldoi
10.1016/j.steroids.2018.03.001subject
Has Abstractpub_date
2018-08-01 00:00:00pages
63-75eissn
0039-128Xissn
1878-5867pii
S0039-128X(18)30046-1journal_volume
136pub_type
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