Abstract:
:The steroid hormone dehydroepiandrosterone (DHEA) has beneficial effects on vascular function, survival of neurons, and fatty acid metabolism. However, a specific receptor for DHEA has not been identified to date. Here, we describe the synthesis of a photoreactive DHEA derivative (Photo-DHEA). In Photo-DHEA, typical characteristics of DHEA are conserved: (i) a "planar" tetracyclic ring system with a Δ(5) double bond, (ii) a 3β-hydroxyl group, and (iii) a keto group at C17. In cell-based assays, Photo-DHEA showed the same properties as DHEA. We conclude that Photo-DHEA is suitable for radioiodination to yield a tool for the identification of the elusive DHEA receptor.
journal_name
Steroidsjournal_title
Steroidsauthors
Waschatko G,Kojro E,Zahnow M,Gehrig-Burger Kdoi
10.1016/j.steroids.2011.01.009subject
Has Abstractpub_date
2011-04-01 00:00:00pages
502-7issue
5eissn
0039-128Xissn
1878-5867pii
S0039-128X(11)00038-9journal_volume
76pub_type
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