Abstract:
:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations of endogenous oestrogens, and other endogenous hormones, with breast cancer risk. In postmenopausal women, relatively high serum concentrations of oestradiol are associated with a more than twofold increase in the risk for breast cancer, and this probably explains the increase in risk in obese postmenopausal women. In premenopausal women the data available on oestrogens are more limited and difficult to interpret due to the large variations in endogenous oestrogens during the menstrual cycle, but are compatible with a positive association between oestradiol and breast cancer risk. There is also evidence that breast cancer risk is positively associated with androgens, prolactin and insulin-like growth factor-I. Further data are required, with better assays and repeat measures, to provide more accurate estimates of risk and to clarify the role of oestrogens in premenopausal women and the roles of other endogenous hormones.
journal_name
Steroidsjournal_title
Steroidsauthors
Key TJdoi
10.1016/j.steroids.2011.02.029subject
Has Abstractpub_date
2011-07-01 00:00:00pages
812-5issue
8eissn
0039-128Xissn
1878-5867pii
S0039-128X(11)00069-9journal_volume
76pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Steroid delta 4-5 alpha- and delta 4-5 beta-reductase activity was determined in 16 human mammary tumors and 8 DMBA-induced rat mammary tumors using a spectrophotometric assay. Steroid delta 4-5 alpha-reductase was present in all tumors investigated while delta 4-5 beta-reductase was detected in only 6 estrogen recept...
journal_title:Steroids
pub_type: 历史文章,杂志文章
doi:10.1016/s0039-128x(79)80010-0
更新日期:1979-01-01 00:00:00
abstract::The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(84)90023-0
更新日期:1984-06-01 00:00:00
abstract::Thyroid hormone receptors (TRs) are nuclear receptors that are activated by thyroid hormone ligands and co-regulator proteins. Two receptor subtypes, TRalpha and TRbeta, have been suggested to play a role in numerous physiological functions. However, specificity of receptor subtype function and co-regulator interactio...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.11.014
更新日期:2009-02-01 00:00:00
abstract::Brassinosteroid (BR) phytohormones play indispensable roles in plant growth and development. Brassinolide (BL) and 24-epibrassinolide (24-epiBL) are the most active ones among the BRs reported thus far. Unfortunately, the extremely low natural content and intricate synthesis process limit their popularization in agric...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.09.002
更新日期:2015-12-01 00:00:00
abstract::Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::Dioscorea panthaica is a traditional Chinese medicinal herb used in the treatment of various physiological conditions, including cardiovascular disease, gastropathy and hypertension. Steroidal saponins (SS) are the main active ingredients of this herb and have effects on myocardial ischemia and cancer. The phytochemic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.12.023
更新日期:2015-03-01 00:00:00
abstract::17beta-estradiol exerts an antiapoptotic action in skeletal muscle cells through extranuclear ERalpha and beta. This protective action, mainly involves a non-genomic mechanism of ERK1/2 and PI3K/Akt activation and BAD phosphorylation. ERbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.12.027
更新日期:2008-10-01 00:00:00
abstract::Ventral prostate was used as a system to study the nature and properties of microsomal androgen receptor. The endoplasmic reticulum from rat ventral prostate contains high-affinity, low-capacity binding sites for androgen that are intrinsic to this intracellular compartment. Microsomal androgen receptors are not due t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90126-g
更新日期:1991-02-01 00:00:00
abstract::The effect of sodium intake on the aldosterone metabolic clearance rate (MCR) was examined in 5 normal subjects. Measurements were made under conditions where dietary sodium ranged from 10 to 1500 meq/day. There were no consistent changes in MCR over these extremes of sodium intake, and the plasma level of aldosterone...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90002-7
更新日期:1981-01-01 00:00:00
abstract::A series of novel 5α, 8α-endoperoxide steroidal hybrid derivatives containing isatin or indole substituents on the C-17 side chain were synthesized and characterized. The preliminary anti-proliferative activity of the compounds against HepG2, MCF-7, HT-29 and HeLa cell lines were investigated. Compounds 7g and 7l disp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108471
更新日期:2020-01-01 00:00:00
abstract::In an endeavour to develop potent anti-tumor agents from diosgenin, a series of C-6 derived 1,2,3-triazolyl derivatives were designed and synthesized by employing Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition reaction of novel azides - (22R,25R)-6β-azidospirostan-3β,5α-diol and 6β-azido-7α-hydroxyspirosta-1,4-dien...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108460
更新日期:2019-11-01 00:00:00
abstract::The hydrolysis of 108 esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) was studied in vitro using a rabbit liver preparation. Introduction of a double or triple bond into a straight-chain ester did not inhibit hydrolysis but a marked reduction in hydrolysis was produced on replacement of a me...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90110-1
更新日期:1983-03-01 00:00:00
abstract::The structure of dehydro-oogoniol (3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one), a female-activating hormone of the water mold Achlya, has been confirmed by synthesis. The starting material was progesterone, which was converted to the 11 alpha, 15 beta-dihydroxy derivative by microbiologica...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90019-6
更新日期:1989-03-01 00:00:00
abstract::Estrogen sulfamates are promising hormones by oral administration. Therefore, generally applicable and convenient methods for the multigram synthesis of these derivatives are desirable. Numerous estra-1,3,5(10)-trienes derived from estrone, estradiol. 14 alpha,15 alpha-methylenestradiol, ethinylestradiol, and estriol ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00200-0
更新日期:1996-12-01 00:00:00
abstract::The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90018-6
更新日期:1982-10-01 00:00:00
abstract::Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers bearing these signaling proteins. To assess these growth-promoting pathways, we undertook controlled homogenization and fractionation of NIH-H23 non-small cell...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.017
更新日期:2005-05-01 00:00:00
abstract::Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational st...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.05.011
更新日期:2014-09-01 00:00:00
abstract::In demyelinating or non-demyelinating neurodegenerative diseases, increased levels of 7-ketocholesterol (7KC), 7β-hydroxycholesterol (7β-OHC) and 24(S)-hydroxycholesterol (24S-OHC) can be observed in brain lesions. In 158N murine oligodendrocytes, 7KC triggers a complex mode of cell death defined as oxiapoptophagy, in...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.02.003
更新日期:2015-07-01 00:00:00
abstract::Estradiol (E2) and other steroids have recently been shown to initiate various intracellular signaling cascades from the plasma membrane, including those stimulating mitogen-activated protein kinases (MAPKs), and particularly extracellular-regulated kinases (ERKs). In this study we demonstrated the ability of E2 to ac...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2003.12.003
更新日期:2004-03-01 00:00:00
abstract::The present study was undertaken to examine the mechanism whereby beta-lipotropin stimulates adrenal steroidogenesis. In guinea pig adrenal cells, beta-lipotropin (10(-8) M) increased basal steroid production 6-, 4-, and 5-fold for cortisol, androstenedione, and dehydroepiandrosterone (DHEA), respectively, whereas the...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(96)00002-5
更新日期:1996-05-01 00:00:00
abstract::The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108432
更新日期:2019-10-01 00:00:00
abstract::The kinetics of 11 beta-hydroxysteroid dehydrogenase (11HSD) catalyzing the interconversion of cortisol (F) and cortisone (E) were compared in vitro following incubation of homogenates of human (N = 7) and baboon (N = 2) placenta. In both species, enzyme activity catalyzing the conversion of F to E was associated with...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(84)90004-7
更新日期:1984-09-01 00:00:00
abstract::The metabolism of a C26 bile alcohol (I, 24-nor-5beta-cho-lestane-3alpha, 7alpha,25-triol) was studied in the isolated perfused rabbit liver. The new bile alcohol and bile acid metabolites secreted into the bile were isolated and identified by a combination of TLC, GLC and GLC-MS. The following bile alcohols were foun...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90099-x
更新日期:1977-10-01 00:00:00
abstract::Two dimeric steroidal terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols were prepared starting from cholesterol in a five-step synthetic sequence. X-ray crystallography shows that the obtained compounds display novel supramolecular networks in the solid state in which the facial hydrophobicity of the st...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.03.001
更新日期:2016-05-01 00:00:00
abstract::Cell cycle regulator p21(CIP1) has controversial biological effects in breast cancer since in spite of its role as cell cycle inhibitor and promoter of cellular senescence, it also induces cell proliferation and chemoteraphy resistance. We here explored the molecular mechanisms involved in progestin regulation of p21(...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.11.003
更新日期:2013-06-01 00:00:00
abstract::Oleoyl-estrone (OE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2009.09.009
更新日期:2010-01-01 00:00:00
abstract::Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.06.005
更新日期:2015-09-01 00:00:00
abstract::Glucuronidation of 24,25-dihydroxyvitamin D3 has been investigated in in vitro and in vivo experiments. Three positional isomers of 24,25-dihydroxyvitamin D3 monoglucuronide were synthesized from 24,25-dihydroxyprovitamin D3 derivatives with Koenigs-Knorr reaction and used as standard samples. In the presence of the r...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00057-4
更新日期:1999-10-01 00:00:00
abstract::The configurations at C-24 of 24-alkylsterols of six samples of Clerodendrum species (Verbenaceae) - the aerial parts of C. fragrans, C. inerme, C. infortunatum, C. scandens, and C. siphonanthus, and the seeds of C. infortunatum - were examined by NMR. All samples contained 24 beta-ethylsterols possessing a delta 25-b...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90036-6
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:Abnormal secretion of thyroid hormones, growth hormone, cortisol and androgens influences body composition. We hypothesised that higher cortisol excretion, in combination with higher androgen and IGF-I concentrations, had a synergistic, favourable effect on body mass and bone. DESIGN, PATIENTS AND METHODS:Th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.09.006
更新日期:2016-11-01 00:00:00