Abstract：
:Estrogen sulfamates are promising hormones by oral administration. Therefore, generally applicable and convenient methods for the multigram synthesis of these derivatives are desirable. Numerous estra-1,3,5(10)-trienes derived from estrone, estradiol. 14 alpha,15 alpha-methylenestradiol, ethinylestradiol, and estriol have been esterified with sulfamoyl chloride and N-methylsulfamoyl chloride by a novel approach involving the use of 2,6-di-tert-butylpyridines as bases and chemoselective hydroxy group protections. These pathways circumvent the nonselective formation of esters and side reactions by in situ generated azasulfenes. For toxicological and clinical studies a new synthesis of estrone sulfamate on a 100-g scale was developed using dimethylformamide as the solvent and base.
journal_name
Steroidsjournal_title
Steroidsauthors
Schwarz S,Thieme I,Richter M,Undeutsch B,Henkel H,Elger Wdoi
10.1016/s0039-128x(96)00200-0subject
Has Abstractpub_date
1996-12-01 00:00:00pages
710-7issue
12eissn
0039-128Xissn
1878-5867pii
S0039-128X(96)00200-0journal_volume
61pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:Explants prepared from the neocortex and the fetal zone of the human fetal adrenal (gestational age 13 to 18weeks) were maintained under conditions of organ culture for 7 to 9 days during which time they were exposed to hACTH and various related peptides. Corticotrophic activity was monitored by the daily release of d...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90037-5
更新日期：1978-04-01 00:00:00
abstract：:A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.02.001
更新日期：2013-05-01 00:00:00
abstract：:Three new pregnane steroids, 2beta,3beta,5beta-trihydroxy-pregn-20-en-6-one (1), 3beta-hydroxy-5alpha-pregn-7,20-dien-6-one (2), and 3beta-acetoxy-5alpha-pregn-7,20-dien-6-one (3) were isolated from the twigs and leaves of Turraea pubescens, and were structurally elucidated on the basis of spectroscopic data and chemi...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2006.04.010
更新日期：2006-08-01 00:00:00
abstract：:Androgens including testosterone and dihydrotestosterone play important roles on brain structure and function, either directly through androgen receptor or indirectly through estrogen receptors, which need coactivators for their transcription activation. Steroid receptor coactivator-1 (SRC-1) has been shown to be mult...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.06.006
更新日期：2014-10-01 00:00:00
abstract：:3 beta-Hydroxy-5-androsten-17-one is converted to 5-androstene-3, 17-dione by rat liver alcohol dehydrogenase (ADH). We have reported on the purity of the enzyme which is eluted with pyrazole as a single homogeneous protein using an AMP-agarose affinity column. Rat liver ADH can oxidize hydroxyl groups not only at 3 b...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(82)90079-4
更新日期：1982-11-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) reduces body fat in rodents and humans, and increases glycerol release from isolated rat epididymal adipocytes and human visceral adipose tissue explants. It suggests that DHEA stimulates triglyceride hydrolysis in adipose tissue; however, the mechanisms underlying this action are still u...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.08.002
更新日期：2012-11-01 00:00:00
abstract：:Cholesterol side-chain cleavage (CSCC) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. CSCC activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin whic...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(77)90042-3
更新日期：1977-02-01 00:00:00
abstract：:Circadian rhythms in physiology and behavior are known to be influenced by the estrous cycle in female rodents. The clock genes responsible for the generation of circadian oscillations are widely expressed both within the central nervous system and peripheral tissues, including those that comprise the reproductive sys...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.01.007
更新日期：2010-03-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.02.006
更新日期：2011-05-01 00:00:00
abstract：:In an attempt to justify use of trypsin to achieve more thorough dispersion of luteal cell clumps in vitro, progesterone (P) production by collagenase dispersed monkey luteal cells from the mid-luteal phase corpus luteum (CL) was examined in vitro either after 10 min, or continuous (3h) exposure to trypsin (TR). In th...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(80)90110-5
更新日期：1980-01-01 00:00:00
abstract：:In addition to using radioimmunoassays for the determination of estrogens and other steroids, the possibility of using mass fragmentography for analysis was investigated. t-Butyldimethylsilyl chloride was selected as a reagent for derivatisation because it forms rather stable silylethers. In all the mass-spectra obrai...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90013-8
更新日期：1979-04-01 00:00:00
abstract：:Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas def...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(81)90032-5
更新日期：1981-08-01 00:00:00
abstract：:16alpha-hydroxydehydroepiandrosterone was for the first time detected in human seminal plasma by using a combination of extraction, solvent partition, HPLC separation and final quantification by GC-MS as pentafluorobenzyloxime trimethylsilyl ether derivative in SIM mode. Three effective mass fragments m/z 266, 356 and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.05.017
更新日期：2004-10-01 00:00:00
abstract：:Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2003.08.002
更新日期：2003-11-01 00:00:00
abstract：:Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational st...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.05.011
更新日期：2014-09-01 00:00:00
abstract：:The synthesis of 6alpha- and 6beta-testosterone-bovine serum albumin (BSA) conjugates is described. 6beta-Carboxymethyl-4-androstene-3,17-dione was prepared by a route analogous to that described earlier for 6beta-carboxymethyl progesterone. Sodium borohydride reduction of the 3 and 17 keto groups and subsequent selec...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(75)80004-3
更新日期：1975-01-01 00:00:00
abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.01.003
更新日期：2004-04-01 00:00:00
abstract：:Novel androstanopyrazoles have been efficiently synthesized from steroidal β-ketoaldehydes with different arylhydrazine hydrochlorides both under acidic and basic conditions. Knorr-type transformations of 16-hydroxymethylene-dehydroepiandrosterone containing its 1,3-dicarbonyl moiety on ring D, proved to be regioselec...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2017.08.003
更新日期：2017-10-01 00:00:00
abstract：:Ten sex steroids were measured in the peripheral serum and ovarian follicular fluid of female pigs with or without cystic ovarian disease. In general, progestin, especially progesterone, accumulated excessively in the fluid contained in cystic compared with normal follicles. Nonluteinized cystic follicles contained up...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(90)90036-b
更新日期：1990-07-01 00:00:00
abstract：:Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.10.015
更新日期：2013-02-01 00:00:00
abstract：:Nucleocytoplasmic shuttling of glucocorticoid receptors (GRs) is disrupted in v-mos-transformed cells leading to the redistribution of hormone-bound receptors from the nuclear to cytoplasmic compartments. We show here that GRs from v-mos-transformed cells are hyperphosphorylated on a specific peptide and maintain horm...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(94)00068-n
更新日期：1995-05-01 00:00:00
abstract：:Plasma concentrations of dehydroepiandrosterone (DHEA), 5-androstene-3beta,17beta-diol (AED), and 17beta-estradiol (E2) in dairy cows and heifers and AED binding to uterine cytosolic estrogen receptor (ER) were studied. Plasma samples were collected from the subcutaneous abdominal (SA) and jugular (J) veins of heifers...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2003.12.001
更新日期：2004-02-01 00:00:00
abstract：:Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well know...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2009.10.014
更新日期：2010-11-01 00:00:00
abstract：:(25S)-3-Oxocholesta-1,4-dien-26-oic acid (1) and a new (25S)-18-acetoxy-3-oxocholesta-1,4-dien-26-oic acid (2) were isolated from a soft coral Minabea sp. (cf. aldersladei) collected in North Sulawesi, Indonesia, together with two known cholic-acid-type compounds, 3-oxochol-1,4-dien-24-oic acid (3) and 3-oxochol-4-en-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.04.002
更新日期：2009-09-01 00:00:00
abstract：:The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2007.07.009
更新日期：2007-11-01 00:00:00
abstract：:To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.12.005
更新日期：2014-04-01 00:00:00
abstract：:Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.11.001
更新日期：2005-03-01 00:00:00
abstract：:These studies investigated whether treatment with carbenoxolone (CBX), an inhibitor of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), resulted in an enhanced mineralocorticoid response to endogenous or infused cortisol. In conscious sodium replete sheep with a parotid fistula, infusion of CBX (40 mg/h for 10 days...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(97)00141-4
更新日期：1998-02-01 00:00:00
abstract：:Glucocorticoids (GCs) are essential steroid hormones that regulate numerous metabolic and homeostatic functions in almost all physiological systems. Synthetic glucocorticoids are among the most commonly prescribed drugs for the treatment of various conditions including autoimmune, allergic and inflammatory diseases. G...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2017.11.002
更新日期：2018-05-01 00:00:00
abstract：:Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(99)00108-7
更新日期：2000-04-01 00:00:00
