Abstract：
:These studies investigated whether treatment with carbenoxolone (CBX), an inhibitor of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), resulted in an enhanced mineralocorticoid response to endogenous or infused cortisol. In conscious sodium replete sheep with a parotid fistula, infusion of CBX (40 mg/h for 10 days) did not increase mean arterial pressure, or change sodium and potassium status or plasma renin concentration, but significantly increased the half-life of 1,2[3H] cortisol from 18.6 +/- 4.0 to 38.8 +/- 3.9 min (p < 0.05) and reduced the blood clearance rate of cortisol (BCR) from 31 +/- 3 to 15 +/- 4 L/h (p < 0.01). The reduction in cortisol BCR was associated with reduction in cortisol secretion rate from 433 +/- 116 to 181 +/- 79 nmol/h (p < 0.01). Cortisol (8 mg/h) for 5 days increased mean arterial pressure (from 83 +/- 2 to 101 +/- 5 mmHg, p < 0.001) and caused natriuresis, hypokalaemia and hyperglycaemia. These responses were unaltered when cortisol was infused from the fifth to the tenth day of CBX infusion. These findings suggest that in sheep, carbenoxolone is either a less potent inhibitor of 11 beta-HSD2 than in other species or 11 beta-HSD2 may not be the only mechanism, which determines the specificity of the MR.
journal_name
Steroidsjournal_title
Steroidsauthors
Dodic M,May CN,Coghlan JPdoi
10.1016/s0039-128x(97)00141-4subject
Has Abstractpub_date
1998-02-01 00:00:00pages
99-104issue
2eissn
0039-128Xissn
1878-5867pii
S0039128X97001414journal_volume
63pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:A convenient procedure for the synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol via a modified homologation sequence of the intermediate 3 alpha,7 alpha,12 alpha-triformyloxy-24-oxo-25-diazo-25-homo-5 beta-cholane involving a homogeneous medium is described. This involves treating the intermediate alp...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(80)90144-0
更新日期：1980-04-01 00:00:00
abstract：:3beta-Hydroxy sterols occurring at a concentration of at least 0.001% of the sterol mixtures of Pseudoplexaura porosa and Plexaura homomalla have been fractionated using a series of refined techniques and subsequently analyzed using combined gas chromatography-mass spectrometry (GC-MS) in the development of a procedur...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(76)90009-x
更新日期：1976-11-01 00:00:00
abstract：:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.02.029
更新日期：2011-07-01 00:00:00
abstract：:The reaction of 23-oxotigogenin acetate with TMSOTf in THF afforded the corresponding bisnorcholanic lactone in 60% yield. The analogous reactions carried out in dichloromethane or benzene gave the rearranged products--the isomeric spirostanic ketone (10-15%) and bisfuran (40-42%). Similar products were also obtained ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.02.010
更新日期：2009-08-01 00:00:00
abstract：:Novel C6-cyclo secondary amine substituted purine steroid-nucleoside analogues (2-9) were efficiently synthesized through displacement of the C6 chloro on the purine ring of series 1 with versatile cyclic secondary amines, including pyrrolidines, piperidine, morpholine, and piperazines. All the newly-synthesized compo...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.03.017
更新日期：2014-07-01 00:00:00
abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol to cortisone, allowing the non-selective mineralocorticoid receptor to bind aldosterone. When the activity of this enzyme is compromised, as occurs in licorice intoxication or in the congenital syndrome of apparent mineralocortico...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(96)00013-x
更新日期：1996-04-01 00:00:00
abstract：:Oleoyl-estrone (OE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of t...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.09.009
更新日期：2010-01-01 00:00:00
abstract：:Starting from the structure of ice (in which each water molecule is surrounded by other four water molecules forming a tetrahedron with a value of 4.51Å for the edge O-O distance), and the knowledge that this value also corresponds to the O7-O12 distance of the skeleton of cholic acid, it is hypothesized that two ster...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.07.003
更新日期：2012-10-01 00:00:00
abstract：:The 1,3-dipolar cycloaddition of azomethine ylide derived in situ from the reaction of acenaphthylene-1,2-dione and 1,3-thiazolane-4-carboxylic acid to various exocyclic dipolarophiles synthesized from trans-androsterone and trans-dehydroandrosterone afforded a library of novel spiro[5'.2″]acenaphthylene-1″-one-spiro[...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.12.017
更新日期：2013-04-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.08.005
更新日期：2012-11-01 00:00:00
abstract：:The free sterol mixture of the sponge Psammaplysilla purpurea was shown to contain aplysterol as the major constituent. In addition to other sterols such as 5,7-cholestadien-3beta-ol, cholesterol, 5alpha-cholestan-3beta-ol, 24epsilon-methylcholesta-5,22-dien-3beta-ol, 24epsilon--methylcholesterol, 24epsilon-ethylchole...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(78)80046-4
更新日期：1978-06-01 00:00:00
abstract：:Spectroscopic examination of purified extracts of the rumen content of sheep intoxicated by Brachiaria decumbens revealed the presence of two spirostanes, identified as epi-sarsasapogenin and epi-smilagenin. Sarsasapogenone was obtained by the oxidation of sarsasapogenin. The reduction of sarsasapogenone using lithium...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(93)90043-m
更新日期：1993-08-01 00:00:00
abstract：:The hypothesis tested in the present work is that estrone non-genomically regulates aortic nitric oxide synthase (NOS) and cyclooxygenase (COX) activities in female rats, and that such regulation depends on ovarian function. We found that physiological concentrations of estrone (E(1)) (0.1-10nM) significantly increase...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.10.012
更新日期：2005-04-01 00:00:00
abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2014.08.013
更新日期：2014-12-01 00:00:00
abstract：:In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated. The triazene prepared from the amino-clomiphene...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(86)90042-5
更新日期：1986-07-01 00:00:00
abstract：:Anabolic androgenic steroids (AAS) are testosterone and testosterone-derivative compounds sporadically employed by athletes and increasingly used recreationally to acquire a competitive edge or improve body composition. Nevertheless, users are subject to undesired side effects majorly associated with tissue-specific a...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2020.108753
更新日期：2020-12-01 00:00:00
abstract：:The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(92)90092-n
更新日期：1992-01-01 00:00:00
abstract：:Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P (GP) reagent to give GP hydrazones. Steroid GP hydrazones contain a quaternary nitrogen atom and are readily ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2005.08.002
更新日期：2006-01-01 00:00:00
abstract：:A radioimmunoassay technique has been developed for the measurement of cortisol in a single methylene chloride extract of human plasma without chromatography. The antiserum, obtained by immunizing rabbits with cortisol-3-carboxymethyl-oxime conjugated to bovine serum albumin, had a high affinity (KA = 1.8 X 10(9) 1/mo...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(75)90057-4
更新日期：1975-11-01 00:00:00
abstract：:1 alpha, 25-Dihydroxyvitamin D3 (1 alpha, 25-(OH)2D3) has been shown to rapidly increase cytosolic calcium in freshly isolated and cultured rat hepatocytes. The rise in cytosolic calcium is dependent on phospholipase A2 (PLA2) activation and cell alkalinization through the Na+/H+ antiport system. To further characteri...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(93)90008-b
更新日期：1993-10-01 00:00:00
abstract：:The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.11.009
更新日期：2005-03-01 00:00:00
abstract：:Determinations of oxygen solubility in serum were made utilizing various concentrations of corticosteroids in the serum. Within a certain concentration range dexamethasone and betamethasone caused an increase in oxygen solubility. None of the other steroids tested demonstrated this property. ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(76)90041-6
更新日期：1976-09-01 00:00:00
abstract：:The mechanistic aspects of the alkali-catalyzed rearrangement of 16alpha-hydroxy-17-keto steroid 1 to 17beta-hydroxy-16-keto steroid 2 are elucidated by use of (18)O- and deuterium-labeling experiments. The (18)O-labeling experiments refute the gem-hydration-quasi-diaxial dehydration mechanism for the rearrangement pr...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2008.03.001
更新日期：2008-09-01 00:00:00
abstract：:A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(80)90065-3
更新日期：1980-07-01 00:00:00
abstract：:The relationship between 14CO2 evolution from the catabolism of [26 or 2714C] cholesterol to bile acids was studied in rats with biliary fistulae. When equal quantities of [26 or 2714C] cholesterol and [414C] cholesterol were administered, there was a significant linear relationship between 14CO2 expiration in the bre...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(75)90062-8
更新日期：1975-10-01 00:00:00
abstract：:C-4 and C-6 bridged haptens of 11 alpha-hydroxyprogesterone, an anti-androgen, were respectively synthesized via 4, 5 and 5 alpha, 6 alpha epoxide ring openings using 3-mercaptopropanoic acid. Substitution of 6-bromo derivative of progesterone using the same reagent unexpectedly afforded a C-4 substituted product inst...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(89)90063-9
更新日期：1989-06-01 00:00:00
abstract：:The binding activity of four vitamin D metabolites and/or analogs for the intestinal 1,25-dihydroxyvitamin D3 receptor was evaluated after incubation at 25 degrees C for 1 h or at 0-4 degrees C for 18 h. The incubation conditions, which had no effect on the binding of 1,25-dihydroxyvitamin D3, had a dramatic effect on...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(88)90054-2
更新日期：1988-05-01 00:00:00
abstract：:From the fruiting bodies of Ascomycetes Tuber indicum, a new steroidal glucoside with polyhydroxy ergosterol nucleus, tuberoside (2), has been isolated along with additional four known ergosterol derivatives, (22E, 24R)-ergosta-7, 22-dien-3beta, 5alpha, 6beta-triol (1), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6, 22...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(01)00105-2
更新日期：2001-10-01 00:00:00
abstract：:The ALVA-41 cell line was derived from a bony metastasis from a human prostatic carcinoma. The line has a number of distinct, advantageous properties that should make it useful as a tool for the study of prostate cancer. It grows rapidly and is easy to work with. It has receptors for androgens and glucocorticoids but ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(94)90052-3
更新日期：1994-10-01 00:00:00
abstract：:While the neuroprotective benefits of estrogen and progesterone in critical illness are well established, the data regarding the effects of androgens are conflicting. Surgical repair of congenital heart disease is associated with significant morbidity and mortality, but there are scant data regarding the postoperative...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.11.003
更新日期：2014-03-01 00:00:00
