17beta-estradiol signaling in skeletal muscle cells and its relationship to apoptosis.

abstract：:The first natural occurrence of 19-norcholestenone is reported, together with 17 sterols and one other delta 4-3-ketone in the extracts of the Californian gorgonian, Muricea californica (Aurivillius). Six additional demethyl sterols and five additional 4-monomethyl sterols which remain unidentified were also detected....

journal_title：Steroids

authors： Popov S,Carlson RM,Djerassi C

更新日期：1983-04-01 00:00:00

abstract：:Chronic kidney disease results in a reduction in 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and an accumulation of phosphorus in the blood, leading to secondary hyperparathyroidism and renal osteodystrophy. Vitamin D analogs that retain the ability to suppress PTH but that are less calcemic and phosphatemic than...

journal_title：Steroids

authors： Williams KB,DeLuca HF

更新日期：2008-11-01 00:00:00

abstract：:Five new steroidal alkaloids, 5,14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-pregn-5,14-diene] (1), 14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-5alpha-pregn-14-ene] (2), 16-dehydrosarcorine [(20S)-20-(N,N-dimethylamino)-3beta-(N(a)-ac...

journal_title：Steroids

authors： Atta-ur-Rahman,Feroz F,Naeem I,Zaheer-ul-Haq,Nawaz SA,Khan N,Khan MR,Choudhary MI

更新日期：2004-10-01 00:00:00

abstract：:The purpose of this study was to determine the short-term effects of progesterone action on estrogen receptor (Re) levels in the rat uterus. Ovariectomized, adrenalectomized rats were maintained on subcutaneous Silastic implants containing crystalline estradiol. Progesterone treatment with serum estradiol maintenance ...

journal_title：Steroids

authors： Okulicz WC,Evans RW,Leavitt WW

更新日期：1981-04-01 00:00:00

abstract：:Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations. Steroid effects were concentration-dependent...

journal_title：Steroids

authors： Mattson MP,Mrotek JJ

更新日期：1985-07-01 00:00:00

abstract：:Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...

journal_title：Steroids

authors： Li H,Xie H,Fu M,Li W,Guo B,Ding Y,Wang Q

更新日期：2013-02-01 00:00:00

abstract：:18,20-Epoxy-11 beta,17 alpha,20 beta,21-tetrahydroxypregn-4-en-3-one was synthesized by the application of hypoiodite reaction to the cortisol acetonide. The intermediary 18-iodo derivative was converted to the 11-oxo steroid by chromic acid prior to silver ion-assisted solvolysis. Removal of the protective group with...

journal_title：Steroids

authors： Kurosawa T,Ikegawa S,Chiba H,Ito Y,Nakagawa S,Kobayashi K,Tohma M

更新日期：1992-09-01 00:00:00

abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...

journal_title：Steroids

authors： Schneider C,Schöler HF,Schneider RJ

更新日期：2004-04-01 00:00:00

abstract：:Nucleocytoplasmic shuttling of glucocorticoid receptors (GRs) is disrupted in v-mos-transformed cells leading to the redistribution of hormone-bound receptors from the nuclear to cytoplasmic compartments. We show here that GRs from v-mos-transformed cells are hyperphosphorylated on a specific peptide and maintain horm...

journal_title：Steroids

authors： Borror KC,Garabedian MJ,DeFranco DB

更新日期：1995-05-01 00:00:00

abstract：:Sedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of mu...

journal_title：Steroids

authors： Fink J,Matsumoto M,Tamura Y

更新日期：2018-10-01 00:00:00

abstract：:Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The result...

journal_title：Steroids

authors： Cui J,Pang L,Wei M,Gan C,Liu D,Yuan H,Huang Y

更新日期：2018-12-01 00:00:00

abstract：:The influence of daily injections, for 7 days, of 17-hydroxyprogesterone caproate (8 mg/100 g body weight pro die), of estradiol-17 beta 17-undecylate (1.2 mg/100 g body weight pro die) of testosterone enanthate (2 mg/100 g body weight pro die) and of ACTH (4 IU/100 g body weight pro die) to male Wistar rats, weighing...

journal_title：Steroids

authors： Bukhari AR,Guessab A,Nicol ML

更新日期：1981-07-01 00:00:00

abstract：:Six naturally occurring C27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20hydroxyecdysone, 3-epi-20,26-d...

journal_title：Steroids

authors： Kaplanis JN,Thompson MJ,Dutky SR,Robbins WE

更新日期：1979-09-01 00:00:00

abstract：:Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects...

journal_title：Steroids

authors： Tsai CC,Tey SL,Chang LC,Su YT,Lin KJ,Huang SC

更新日期：2018-08-01 00:00:00

abstract：:It has been shown by others that treatment with only progesterone is sufficient to induce implantation and maintain pregnancy in ovariectomized-adrenalectomized rabbits. Based on these results, it was deduced that induction of implantation in the rabbit does not require estrogen. In making this deduction, "blastocyst ...

journal_title：Steroids

authors： Dey SK,Dickmann Z,Sen Gupta J

更新日期：1976-10-01 00:00:00

abstract：:The binding activity of four vitamin D metabolites and/or analogs for the intestinal 1,25-dihydroxyvitamin D3 receptor was evaluated after incubation at 25 degrees C for 1 h or at 0-4 degrees C for 18 h. The incubation conditions, which had no effect on the binding of 1,25-dihydroxyvitamin D3, had a dramatic effect on...

journal_title：Steroids

authors： Link RP,DeLuca HF

更新日期：1988-05-01 00:00:00

abstract：:Here we report on the progress we have made in elucidating the mechanisms through which estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation by estrogen of the coupling of various receptor systems to inwardly rectifying and small conductance, Ca(2+)-activated K(+) (SK) channels. We us...

journal_title：Steroids

authors： Kelly MJ,Rønnekleiv OK,Ibrahim N,Lagrange AH,Wagner EJ

更新日期：2002-05-01 00:00:00

abstract：:A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of...

journal_title：Steroids

authors： Ohnuma N,Kiyoki M,Bannai K,Naruchi T,Hashimoto Y,Noguchi T,Norman AW

更新日期：1980-07-01 00:00:00

abstract：:The non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key ...

journal_title：Steroids

authors： Alzamora R,Harvey BJ

更新日期：2008-10-01 00:00:00

abstract：:A highly sensitive and specific quantification method of estrone and estradiol in human serum was described based upon the use of picolinoyl derivatization and liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) in a positive mode. Estrogens were treated with picolinoyl chloride hydrochloride o...

journal_title：Steroids

authors： Yamashita K,Okuyama M,Watanabe Y,Honma S,Kobayashi S,Numazawa M

更新日期：2007-10-01 00:00:00

abstract：:We report the synthesis of 10 novel steroids obtained from 3 beta, 15 beta-diacetoxy-17 alpha-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-1,2,6,...

journal_title：Steroids

authors： Reeder AY,Joannou GE

更新日期：1997-02-01 00:00:00

abstract：:Adrenal function and aging have been the object of intense interest in recent years. In this study we analyzed morning (08:00 h) serum cortisol concentrations from a sample of Chinese subjects aged from 31 to 110 years. These levels differed according to age, health status and sex, although the sex difference was conf...

journal_title：Steroids

authors： Zhao ZY,Lu FH,Xie Y,Fu YR,Bogdan A,Touitou Y

更新日期：2003-08-01 00:00:00

abstract：:The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...

journal_title：Steroids

authors： Jordan VC

更新日期：2007-11-01 00:00:00

abstract：:Ventral prostate was used as a system to study the nature and properties of microsomal androgen receptor. The endoplasmic reticulum from rat ventral prostate contains high-affinity, low-capacity binding sites for androgen that are intrinsic to this intracellular compartment. Microsomal androgen receptors are not due t...

journal_title：Steroids

authors： Steinsapir J,Muldoon TG

更新日期：1991-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine problem affecting women of reproductive age and is investigated from many regions of the world. Some reports have indicated ethnic difference in its manifestation. This review addressed the evidences for ethnic variation in the expression of PCOS phenotypes...

journal_title：Steroids

authors： Zhao Y,Qiao J

更新日期：2013-08-01 00:00:00

abstract：:In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...

journal_title：Steroids

authors： Chinigarzadeh A,Muniandy S,Salleh N

更新日期：2016-11-01 00:00:00

abstract：:Two-hydroxyestrone (2OHE-1) and 16alpha-hydroxyestrone (16OHE-1) are two estrogen metabolites that may play important roles in the development or promotion of breast cancer. Our study assessed the reliability of a newly developed kit procedure for measuring 2OHE-1. Although under certain conditions the assay would not...

journal_title：Steroids

authors： Spierto FW,Gardner F,Smith SJ

更新日期：2001-01-01 00:00:00

abstract：:The chemoselectivity of rigid cyclic alpha,beta-unsaturated carbonyl group on the reducing agents was influenced by the ring size and steric factor. Cholesterol (cholest-5-en-3beta-ol) and dehydroepiandrosterone (DHEA) were oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 1,4,6-cholestatrien-3-one and 1...

journal_title：Steroids

authors： Kim E,Ma E

更新日期：2007-04-01 00:00:00

abstract：:Steroidal nucleoside analogs were synthesized starting from testosterone. By reduction of the oxime of 17 beta-hydroxy-androst-4-en-3-one (testosterone), a mixture of the two amino epimers of C-3 were obtained. The 3 alpha-amino-androst-4-en-17 beta-ol was crystallized in 73% yield and coupled with 5-amino-4,6-dichlor...

journal_title：Steroids

authors： Gelpi ME,Cadenas RA,Mosettig J,Zuazo BN

更新日期：2002-03-01 00:00:00

abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...

journal_title：Steroids

authors： Shutt DA,Shearman RP,Lyneham RC,Clarke AH,McMahon GR,Goh P

更新日期：1975-09-01 00:00:00