Abstract:
:It has been shown by others that treatment with only progesterone is sufficient to induce implantation and maintain pregnancy in ovariectomized-adrenalectomized rabbits. Based on these results, it was deduced that induction of implantation in the rabbit does not require estrogen. In making this deduction, "blastocyst estrogen'' was not taken into account. In the present study, blastocyst development and implantation were prevented by instilling the anti-estrogen CI-628 into the uterine lumina of pregnant, ovariectomized, progesterone-treated rabbits. Our interpretation of these results is that the CI-628 PREVENTED THE ACTION OF "BLASTOCYST ESTROGEN''. However, on the basis of the present results, we cannot determine whether the specific target of "blastocyst estrogen'' is the blastocyst, the uterus, or both.
journal_name
Steroidsjournal_title
Steroidsauthors
Dey SK,Dickmann Z,Sen Gupta Jdoi
10.1016/0039-128x(76)90017-9subject
Has Abstractpub_date
1976-10-01 00:00:00pages
481-5issue
4eissn
0039-128Xissn
1878-5867pii
0039-128X(76)90017-9journal_volume
28pub_type
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