Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins.

abstract：:The use of the synthetic progestin medroxyprogesterone acetate (MPA) for estrus prevention in the dog can result in overproduction of growth hormone, suppression of plasma glucocorticoid levels, and the induction of mammary tumors. Proligestone (PROL) was claimed to be devoid of these unwanted side effects. In the pre...

journal_title：Steroids

authors： Selman PJ,Wolfswinkel J,Mol JA

更新日期：1996-03-01 00:00:00

abstract：:It has been previously demonstrated that 1,25 dihydroxyvitamin D(3) (1,25-D(3)) exerts inhibitory effects in breast cancer cells. The aim of this study was to determine whether mitogen-activated protein kinase (MAPK) pathways are associated with 1,25-D(3)-induced cell death in breast cancer. We used three breast cell ...

journal_title：Steroids

authors： Brosseau CM,Pirianov G,Colston KW

更新日期：2010-12-12 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) increases the growth and osteolytic potential of prostate cancer cells, making it important to control PTHrP expression in these cells. We show that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and its non-hypercalcemic analog, EB1089, decrease PTHrP mRNA and cellular protein leve...

journal_title：Steroids

authors： Sepulveda VA,Weigel NL,Falzon M

更新日期：2006-02-01 00:00:00

abstract：:21-Hydroxypregnenolone and its metabolite 5-pregnene-3 beta, 20 alpha 21-triol have been measured in the sulfate fraction of neonatal urine. These two steroids are the major two 21-hydroxylated 5-pregnenes produced by neonates and are almost exclusively excreted as disulfates. The excretions of these steroids by norma...

journal_title：Steroids

authors： Shackleton CH,Homoki J,Taylor NF

更新日期：1987-04-01 00:00:00

abstract：:We investigated the modulatory effect of estriol (E(3)), an estrogen predominantly produced during human pregnancy, on the antigen-induced production of specific antibodies in female BALB/c mice, and its effect was compared with 17beta-estradiol (E(2)). Estriol (E(3)) had a very different effect than E(2) on the antig...

journal_title：Steroids

authors： Ding J,Zhu BT

更新日期：2008-03-01 00:00:00

abstract：:The bile flow and the bile acid secretion, calculated on liver weight basis, increased 12 H and 24 H after 60-70% hepatectomy and returned to the initial levels thereafter. The biliary phospholipid secretion much more increased than bile acids, but the cholesterol secretion decreased. Bile acid composition changed wit...

journal_title：Steroids

authors： Fukano S,Saitoh Y,Uchida K,Akiyoshi T,Takeda K

更新日期：1985-03-01 00:00:00

abstract：:There are quite substantial number of impurities related to dexamethasone or mometasone which cannot be made from respective Active Pharmaceutical Ingredients but from common intermediate 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione (12). As such, a robust and economical synthesis of this key i...

journal_title：Steroids

authors： Das SK,Dubey MK,Buchhikonda R

更新日期：2019-08-01 00:00:00

abstract：:Two new sterols, (24E)-24-n-propylidenecholesterol and 24 epsilon-n-propylcholesterol, were isolated from a cultured marine Chrysophyte. Since most of the steroids found in marine invertebrates are unchanged or modified sterols of algal or symbiotic origin, the discovery of these two unusual sterols in a unicellular a...

journal_title：Steroids

authors： Rohmer M,Kokke WC,Fenical W,Djerassi C

更新日期：1980-02-01 00:00:00

abstract：:In this study, we assessed the rate of estradiol degradation via the 17 beta-hydroxysteroid dehydrogenase (HSD) enzyme in breast tumors from postmenopausal women. We initially studied the effects of time, level of enzyme activity, amount of tissue assayed, and substrate concentration on the linearity of conversion of ...

journal_title：Steroids

authors： Leszczynski D,Santner SJ,Feil PD,Santen RJ

更新日期：1988-03-01 00:00:00

abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...

journal_title：Steroids

authors： Mihailidou AS,Ashton AW

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...

journal_title：Steroids

authors： de Oliveira C,Iwanaga-Carvalho C,Mota JF,Oyama LM,Ribeiro EB,Oller do Nascimento CM

更新日期：2011-11-01 00:00:00

abstract：:A novel steroid, 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one (gibberoketosterol) (1), along with four known steroids, was isolated from the lipophilic extracts of a Taiwanese soft coral Sinularia gibberosa. The structure of the new metabolite was determined on the basis of extensive spectral analyses and...

journal_title：Steroids

authors： Ahmed AF,Dai CF,Kuo YH,Sheu JH

更新日期：2003-04-01 00:00:00

abstract：:Immature hypophysectomized rats were injected with PMS; some groups received hCG 48h later. The C17,20-lyase activity in the granulosa cells removed from the large preovulatory follicles was estimated by the amount of labelled acetic acid produced from 21 (14C) progesterone or 17-hydroxyprogesterone. 17 alpha-hydroxyl...

journal_title：Steroids

authors： Johnson DC,Griswold T

更新日期：1983-11-01 00:00:00

abstract：:When day 6 rabbit blastocysts were cultured (3 embryos/mL) in medium 199 containing 3.68 microM estradiol-17 beta (E2), 40% of E2 was metabolized in 24 h, at a rate of 18 pmol/embryo(b)/h, yielding 4 major metabolite fractions. Two of them were identified to be estrogen glucosides: 17 beta-hydroxyestra-1,3,5(10)-trien...

journal_title：Steroids

authors： Wu JT,Williams KI

更新日期：1989-10-01 00:00:00

abstract：:To identify new pathways of estrogen action and novel estrogen receptor α (ERα) biomodulators, we performed high throughput screening and used follow on assays and bioinformatics to identify small molecule ERα inhibitors with a novel mode of action. These studies led to identification of rapid extranuclear activation ...

journal_title：Steroids

authors： Zheng X,Andruska N,Yu L,Mao C,Kim JE,Livezey M,Helferich WG,Shapiro DJ

更新日期：2016-10-01 00:00:00

abstract：:Complete analysis of the proton nuclear magnetic resonance spectrum of desoxycorticosterone (DOC) has been made using selective double irradiation, two-dimensional experiments, relaxation rate, and nuclear Overhauser effect measurements in order to specify the structure and conformation of products encountered during ...

journal_title：Steroids

authors： Kouadio L,Bernard P,Sabot JF,Petit-Ramel MM,Barbier CM,Pinatel HJ

更新日期：1988-03-01 00:00:00

abstract：:Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...

journal_title：Steroids

authors： Caldwell JD,Jirikowski GF

更新日期：2014-03-01 00:00:00

abstract：:Acrolein, an α, β-unsaturated aldehyde, exists in a wide range of sources. Acrolein can be not only generated from all types of smoke but also produced endogenously from the metabolism by lipid peroxidation. The cellular influence of acrolein is due to its electrophilic character via binding to and depleting cellular ...

journal_title：Steroids

authors： Yeh YH,Chou JC,Weng TC,Lieu FK,Lin JY,Yeh CC,Hu S,Wang PS,Idova G,Wang SW

更新日期：2016-07-01 00:00:00

abstract：:Four new pregnane glycosides, stelmatocryptonoside A, B, C, and D (1-4), were isolated from the stems of Stelmatocrypton khasianum. On the basis of chemical and spectral data, the structures of 1-4 were established as 3beta, 16alpha-dihydroxy-pregn-5-en-20-one-16-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-...

journal_title：Steroids

authors： Zhang Q,Zhao Y,Wang B,Feng R,Liu X,Cheng T

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:The cut-off value for salivary cortisol measurement for the diagnosis of Cushing's syndrome (CS) may depend both on the severity of the disease and the composition of control group. Therefore, we examined the utility of midnight salivary cortisol measurements in patients who were evaluated for signs and sympt...

journal_title：Steroids

authors： Sereg M,Toke J,Patócs A,Varga I,Igaz P,Szücs N,Horányi J,Pusztai P,Czirják S,Gláz E,Rácz K,Tóth M

更新日期：2011-01-01 00:00:00

abstract：:Steroid derivatives V, VI, VII and VIII reacted with Lawesson's reagent (LR) to produce spiro-oxazaphosphole-4',17-androstene derivative XI, diazaphospholoandrostane XIV and the thionated derivatives XVI and XVII, respectively. The structures of the new compounds were confirmed by analytical and spectroscopic evidence...

journal_title：Steroids

authors： Mohamed NR,Elmegeed GA,Abd-ElMalek HA,Younis M

更新日期：2005-03-01 00:00:00

abstract：:The effects of progesterone, its agonists (progestin RU-5020, glucocorticoid RU-26988) and antagonist (antiprogesterone, anti-glucocorticoid RU-486) were tested on isolated fat cells in vitro. When added to the incubation medium, all four steroids decreased basal glucose oxidation. The inhibitory effect of the steroid...

journal_title：Steroids

authors： Sutter-Dub MT,Kaaya A,Sfaxi Al,Sodoyez-Goffaux F,Sodoyez JC,Sutter BC

更新日期：1988-11-01 00:00:00

abstract：:The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...

journal_title：Steroids

authors： Alvarez M,Jover A,Carrazana J,Meijide F,Soto VH,Tato JV

更新日期：2007-06-01 00:00:00

abstract：:The synthesis of a radioiodinated diethylstilbestrol (DES) derivative is described. This derivative was prepared by coupling the previously synthesized active ester of 6-(4-O-diethylstilbestryl)hexanoic acid with mono-[125I]iodotyramine in dry tetrahydrofuran (20 to 22 C, 16 hours). The mono-[125I]iodotyramine was pre...

journal_title：Steroids

authors： Economou EV,Livaniou E,Evangelatos GP,Ithakissios DS

更新日期：1992-01-01 00:00:00

abstract：:This study describes a new approach using stable isotope methodology in evaluating 11beta-HSD activities in vivo based on urinary excretion of cortisol, cortisone, and their A-ring reduced metabolites. The method involved the measurement of deuterium-labeled cortisol and its deuterium-labeled metabolites by GC/MS simu...

journal_title：Steroids

authors： Kasuya Y,Shibasaki H,Furuta T

更新日期：2000-02-01 00:00:00

abstract：:Steroids with 4-ene-3,6-dione functionality have application in natural product chemistry, as synthetic intermediates and as aromatase inhibitors. Here, we report a two-phase oxidation of a range of steroidal 5-en-3beta-ols into corresponding 4-ene-3,6-diones using a modified Jones oxidation. The new reaction affords ...

journal_title：Steroids

authors： Hunter AC,Priest SM

更新日期：2006-01-01 00:00:00

abstract：:In this paper, we examine corticosteroid 11 beta-oxidation and 11-reduction as properties of the microsomal 11 beta-hydroxysteroid dehydrogenase complex in vertebrate livers. No hepatic activity in the oxidative direction (11 beta -dehydrogenase) was found in the frog, toad, mud puppy, shark, and bird livers. In contr...

journal_title：Steroids

authors： Monder C,Lakshmi V

更新日期：1988-11-01 00:00:00

abstract：:In humans, the onset of adrenache has been found to occur with the appearance of the zona reticularis, the inner zone of the adrenal cortex. Since an increase in the volume of adrenal cortex during maturation in the guinea pig has been associated with the growth of the zona reticularis, we were interested in investiga...

journal_title：Steroids

authors： Bélanger B,Caron S,Boudou P,Fiet J,Bélanger A

更新日期：1992-02-01 00:00:00

abstract：:7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers ...

journal_title：Steroids

authors： Duval D,Prédine J,Emiliozzi R,Milgrom E

更新日期：1980-01-01 00:00:00

abstract：:In this study, we investigated the binding characteristics of [3H]Delta(5)-androstene-3beta,17beta-diol to rabbit vaginal cytosolic and nuclear extracts and in freshly excised intact tissue strips. [3H]delta(5)-Androstene-3beta,17beta-diol bound to a protein(s) in the vaginal nuclear extract with high affinity (K(d)=3...

journal_title：Steroids

authors： Traish AM,Huang YH,Min K,Kim NN,Munarriz R,Goldstein I

更新日期：2004-01-01 00:00:00