Abstract:
:Steroids with 4-ene-3,6-dione functionality have application in natural product chemistry, as synthetic intermediates and as aromatase inhibitors. Here, we report a two-phase oxidation of a range of steroidal 5-en-3beta-ols into corresponding 4-ene-3,6-diones using a modified Jones oxidation. The new reaction affords high yields (77-89%) of product in relatively short reaction times (1-2h). The simplicity of this reaction gives significant advantages over previously reported methodologies.
journal_name
Steroidsjournal_title
Steroidsauthors
Hunter AC,Priest SMdoi
10.1016/j.steroids.2005.07.007subject
Has Abstractpub_date
2006-01-01 00:00:00pages
30-3issue
1eissn
0039-128Xissn
1878-5867pii
S0039-128X(05)00188-1journal_volume
71pub_type
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