Abstract:
:A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 and NCI-H460 tumor cell lines. The pharmacological results confirmed that the α,β-unsaturated carbonyl moiety, a Michael acceptor in ring A, plays a pivotal role in the cytotoxic effect of these derivatives. The compiled pharmacological data may be useful for the design of novel analogous anticancer drugs.
journal_name
Steroidsjournal_title
Steroidsauthors
Jiang CS,Huang CG,Feng B,Li J,Gong JX,Kurtán T,Guo YWdoi
10.1016/j.steroids.2010.08.002subject
Has Abstractpub_date
2010-12-12 00:00:00pages
1153-63issue
13-14eissn
0039-128Xissn
1878-5867pii
S0039-128X(10)00223-0journal_volume
75pub_type
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