Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.

abstract：:Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated. A simple method that does not involve extraction but only the 1:100 d...

journal_title：Steroids

authors： Arioli F,Fidani M,Casati A,Fracchiolla ML,Pompa G

更新日期：2010-04-01 00:00:00

abstract：:The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...

journal_title：Steroids

authors： Zomer G,Stavenuiter JF

更新日期：1990-10-01 00:00:00

abstract：:The importance of computer-aided drug design and development is clear nowadays. These approaches smooth the way of designing some efficient candidates based on drugs in use. At this place, we studied the mechanism of D4-abiraterone (D4A), the active metabolite of Abiraterone (Abi), binding to CYP17A1 compared with Abi...

journal_title：Steroids

authors： Mehralitabar H,Ghasemi AS,Gholizadeh J

更新日期：2021-01-17 00:00:00

abstract：:A highly active inhibitor of the binding of estrone and estradiol-17beta to rat alpha-fetoprotein is demonstrated for the first time in embryo, immature and adult rat sera as well as in fetal and adult human sera. The competitive character and the narrow specificity of this inhibition effect is shown. The major compou...

journal_title：Steroids

authors： Benassayag C,Vallette G,Delorme J,Savu L,Nunez EA,Jayle MF

更新日期：1977-12-01 00:00:00

abstract：:The crystal and molecular structure of 3-methoxy-9(10 leads to 19)abeo-1,3,5(10)-estratrien-17-one has been determined by X-ray analysis in order to ascertain the configuration at C(9). The seven-membered B-ring has a chair conformation and this causes the molecule to bow towards the alpha-face rather than towards the...

journal_title：Steroids

authors： Weeks CM,Rohrer DC,Duax WL

更新日期：1976-02-01 00:00:00

abstract：:Catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give previously unknown aluminacyclopentanes in ∼90% yield; these products were converted in situ to carbo- and heterocyclic (5α)-cholestane derivatives. ...

journal_title：Steroids

authors： D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UM

更新日期：2016-04-01 00:00:00

abstract：:A method for the synthesis and purification of 6beta-iodomethyl-19-norcholest-5(10)-ene-3beta-ol-131I of greater than 98 mole% chemical purity and greater than 99% radiochemical purity is presented. Carbon-13 and proton NMR were used to establish the identity and purity. Discrepancies in the characterization of this c...

journal_title：Steroids

authors： Scott KN,Couch MW,Mareci TH,Williams CM

更新日期：1976-08-01 00:00:00

abstract：:Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grou...

journal_title：Steroids

authors： Hnilickova J,Kohout L,Capdevila E,Esteve A,Vilaplana M,Molist M,Brosa C,Swaczynova-Oklestkova J,Slavikova B

更新日期：2010-12-01 00:00:00

abstract：:Although exogenous glucocorticoids (GC) play a role in the regulation of bone marrow mesenchymal stem/stromal cells (MSCs) proliferation and differentiation, the function of endogenous GC is not well understood. The purpose of this study was to investigate the effect of the blockage of endogenous GC using RU486, an an...

journal_title：Steroids

authors： Yu Y,Wei N,Stanford C,Schmidt T,Hong L

更新日期：2012-01-01 00:00:00

abstract：:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...

journal_title：Steroids

authors： Key TJ

更新日期：2011-07-01 00:00:00

abstract：:During our studies of the hepatic androgen receptor in cynomolgus monkeys, tritiated mibolerone +/- a 200-fold excess of unlabeled mibolerone has been used to determine specific binding in cytosol. During time-course studies, high-capacity, unsaturable binding of [3H]mibolerone was noted after short-term incubations (...

journal_title：Steroids

authors： Koritnik DR,Marschke KB,Koshy A

更新日期：1995-11-01 00:00:00

abstract：:The compounds named in the title have been synthesized from the di-(ethylene ketal) of 21-hydroxy-3,20-dioxo-19-norpregn-5-ene-18, 11 beta-lactone and its 5(10)-ene isomer. Reduction of this mixture 1 with sodium aluminum bis-(methoxyethoxy)hydride furnished the 11 beta, 18, 21-triol 2a. Conversion to the 18,21-diacet...

journal_title：Steroids

authors： Harnik M,Kashman Y,Carmely S,Cojocaru M,Dale SL,Holbrook MM,Melby JC

更新日期：1986-01-01 00:00:00

abstract：:This paper describes three simple and short methods for the conversion of cholic acid into cholylaldehyde with protected hydroxyl groups. The first method involves lithium aluminum hydride reduction of the tetrahydropyranyl ether of methyl cholate and oxidation of the resulting primary alcohol with pyridinium chloroch...

journal_title：Steroids

authors： Batta AK,Tint GS,Dayal B,Shefer S,Salen G

更新日期：1982-06-01 00:00:00

abstract：:Biotransformation of a synthetic progestonic hormone dydrogesterone (1), C21H28O2, with a plant pathogenic fungus Macrophomina phaseolina yielded two new 2 and 3, and a known 4 metabolites. These analogues were identified as, 3β,11α-dihydroxy-5β,9β,10α-pregna-7-ene-6,20-dione (2), 15β-hydroxy-9β,10α-pregna-4,6-diene-3...

journal_title：Steroids

authors： Wajid A,Ahmad MS,Yousuf S,Atia-Tul-Wahab,Jabeen A,Atta-Ur-Rahman,Choudhary MI

更新日期：2019-03-01 00:00:00

abstract：:Contraceptive methods for breastfeeding women should be safe for the mother and infant and should not interfere with lactation. Progestin-only methods meet these conditions and can be used from the sixth week postpartum. Because all progestins are excreted in milk, those that are insufficiently active by the oral rout...

journal_title：Steroids

authors： Massai R,Díaz S,Jackanicz T,Croxatto HB

更新日期：2000-10-01 00:00:00

abstract：:The syntheses and antimitotic activity of several novel 18a-homo-analogs of 2-methoxyestradiol are described. Structural modifications of the parent 2-methoxy-18a-homoestradiol include introduction of unsaturation in the D-ring and methylation of the 17-OH. Of seven analogs synthesized, one has demonstrated superior b...

journal_title：Steroids

authors： Rao PN,Cessac JW,Boyd JW,Hanson AD,Shah J

更新日期：2008-02-01 00:00:00

abstract：:Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well know...

journal_title：Steroids

authors： Cheng J,Hurn PD

更新日期：2010-11-01 00:00:00

abstract：:Studies were carried out on the effect of oxygen tension on progesterone (P) accumulation in rat granulosa cell cultures. At 1-2% oxygen, basal, luteinizing hormone (LH)-stimulated, and follicle stimulating hormone (FSH)-stimulated P accumulations were 20, 18, and 11%, respectively, of P levels at 20% oxygen. Basal P ...

journal_title：Steroids

authors： Koos RD,Feiertag MA

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:A high-throughput, sensitive, specific, mass spectrometry-based method for quantitating estrone (E1), estradiol (E2), and testosterone (T) in postmenopausal human serum has been developed for clinical research. The method consumes 100μl human serum for each measurement (triplicates consume 300μl) and does no...

journal_title：Steroids

authors： Wooding KM,Hankin JA,Johnson CA,Chosich JD,Baek SW,Bradford AP,Murphy RC,Santoro N

更新日期：2015-04-01 00:00:00

abstract：:The hormone 1alpha,25(OH)2vitamin D3 (1,25-D) produces biological responses via both genomic and rapid mechanisms. The genomic responses are linked to a nuclear receptor, while the rapid responses are believed to utilize other signal transduction pathways that are likely linked to a putative cell membrane receptor for...

journal_title：Steroids

authors： Norman AW,Song X,Zanello L,Bula C,Okamura WH

更新日期：1999-01-01 00:00:00

abstract：:A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid (1) with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several one...

journal_title：Steroids

authors： Özdemir Z,Bildziukevich U,Šaman D,Havlíček L,Rárová L,Navrátilová L,Wimmer Z

更新日期：2017-12-01 00:00:00

abstract：:Steroid hormone analysis is widely used in health- and stress-related research to get insights into various diseases and the adaption to stress. Hair analysis has been used as a tool for the long-term monitoring of these steroid hormones. In this study, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) metho...

journal_title：Steroids

authors： Voegel CD,Hofmann M,Kraemer T,Baumgartner MR,Binz TM

更新日期：2020-02-01 00:00:00

abstract：:The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...

journal_title：Steroids

authors： Higashi T,Miura K,Kikuchi R,Shimada K,Hiyamizu H,Ooi H,Iwabuchi Y,Hatakeyama S,Kubodera N

更新日期：2000-05-01 00:00:00

abstract：:The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...

journal_title：Steroids

authors： Antignac JP,Brosseaud A,Gaudin-Hirret I,André F,Bizec BL

更新日期：2005-03-01 00:00:00

abstract：:Orally administered testosterone undecanoate (TU), an anabolic, androgenic steroid, can potentially be abused by athletes. Indirect evidence for detecting oral TU intake could be deduced from the changes in steroid profile post-administration. Direct evidence could be obtained by detection of unchanged TU in plasma. T...

journal_title：Steroids

authors： Peng SH,Segura J,Farré M,González JC,de la Torre X

更新日期：2002-01-01 00:00:00

abstract：:Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...

journal_title：Steroids

authors： Li H,Xie H,Fu M,Li W,Guo B,Ding Y,Wang Q

更新日期：2013-02-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine problem affecting women of reproductive age and is investigated from many regions of the world. Some reports have indicated ethnic difference in its manifestation. This review addressed the evidences for ethnic variation in the expression of PCOS phenotypes...

journal_title：Steroids

authors： Zhao Y,Qiao J

更新日期：2013-08-01 00:00:00

abstract：:The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3). ...

journal_title：Steroids

authors： Brosa C,Puig R,Comas X,Fernández C

更新日期：1996-09-01 00:00:00

abstract：:Synthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expa...

journal_title：Steroids

authors： Tolmacheva IA,Nazarov AV,Eroshenko DV,Grishko VV

更新日期：2018-12-01 00:00:00

abstract：:Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women. Little is known of neuroprotective-neurotrophic effects of DHEAS during stress exposure, either in men or women. This translational st...

journal_title：Steroids

authors： Taylor MK,Stone M,Laurent HK,Rauh MJ,Granger DA

更新日期：2014-09-01 00:00:00