Rat and human embryo and post-natal sera contain a potent endogenous competitor of estrogen-rat alpha-fetoprotein interactions.

abstract：:Estrogen is the key regulator of bone metabolism in both men and women. Menopause and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck and 10.6%, lumbar spine. Estradiol concentrations also predict fractures. Tot...

journal_title：Steroids

authors： Cauley JA

更新日期：2015-07-01 00:00:00

abstract：:A series of amphiphilic derivatives of (3β,17β)-3-hydroxyandrost-5-ene-17-carboxylic acid (1) with the polyamine spermine and three other diamines, 1,2-diaminoethane, piperazine and cadaverine, were synthesized and their antimicrobial activity and cytotoxicity were investigated. Among the target compounds, several one...

journal_title：Steroids

authors： Özdemir Z,Bildziukevich U,Šaman D,Havlíček L,Rárová L,Navrátilová L,Wimmer Z

更新日期：2017-12-01 00:00:00

abstract：:Bile acid derivatives, with and without C-3 sulfate groups, and having either the diazo- or halomethylketone moieties, have been synthesized in good yield and purity. The synthetic sequence, COOH leads to COC1 leads to COCHN2 leads to COCH2X, was used with deoxycholic and cholic acids, which requires carefully control...

journal_title：Steroids

authors： Fried AA,Petrow V,Lack L

更新日期：1979-08-01 00:00:00

abstract：:Inhibition of 5alpha-reduction of testosterone by an anti-androgen TSAA-291 (16beta-ethyl-17beta-hydroxy-4-estren-3-one) was studied in rat ventral prostates and the metabolic conversion of 3H-TSAA-291 was examined both in vitro and in vivo. In the in vitro experiment using nuclear 5alpha-reductase of the prostate, 5a...

journal_title：Steroids

authors： Sudo K,Yoshida K,Akinaga Y,Nakayama R

更新日期：1981-07-01 00:00:00

abstract：:As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...

journal_title：Steroids

authors： Mukherjee D,Engel CR

更新日期：1979-11-01 00:00:00

abstract：:The syntheses of 15beta-carboxyethylmercapto-5alpha-dihydrotestosterone, 15beta-carbosyethylmercapto-5alpha-androstane-3beta, 17beta-diol and 15beta-carboxyethylmercapto-5alpha-androstane-3alpha, 17beta-diol and the preparation of their bovine serum albumin (BSA) conjugates are described. These conjugates were employe...

journal_title：Steroids

authors： Rao PN,Khan AH,Moore PH Jr

更新日期：1977-02-01 00:00:00

abstract：:This article describes the origins and evolution of "antiestrogenic" medicines for the treatment and prevention of breast cancer. Developing drugs that target the estrogen receptor (ER) either directly (tamoxifen) or indirectly (aromatase inhibitors) has improved the prognosis of breast cancer and significantly advanc...

journal_title：Steroids

authors： Jordan VC,Brodie AM

更新日期：2007-01-01 00:00:00

abstract：:The relationship between 14CO2 evolution from the catabolism of [26 or 2714C] cholesterol to bile acids was studied in rats with biliary fistulae. When equal quantities of [26 or 2714C] cholesterol and [414C] cholesterol were administered, there was a significant linear relationship between 14CO2 expiration in the bre...

journal_title：Steroids

authors： Davis RA,Showalter P,Kern F Jr

更新日期：1975-10-01 00:00:00

abstract：:Morphologic changes at the interface of rat endometrial luminal epithelial cells and the stromal cells immediately adjacent were examined and correlated with hypertrophy of the epithelial cells during estradiol (E2) infusion (1 microgram E2/24 h). While the lamina densa in castrate endometrium was thread-like, it beca...

journal_title：Steroids

authors： Lavia LA,Larson BA

更新日期：1991-03-01 00:00:00

abstract：:The conjugation reactions of hydration and dehydrogenation catalyzed by the dehydratase and dehydrogenase activities of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein (DBP) and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase bifunctional protein (LBP) in the side chain degra...

journal_title：Steroids

authors： Kurosawa T,Sato M,Nakano H,Fujiwara M,Murai T,Yoshimura T,Hashimoto T

更新日期：2001-02-01 00:00:00

abstract：:Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...

journal_title：Steroids

authors： Shackleton CH,Hughes BA,Lavery GG,Walker EA,Stewart PM

更新日期：2008-10-01 00:00:00

abstract：:Sedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of mu...

journal_title：Steroids

authors： Fink J,Matsumoto M,Tamura Y

更新日期：2018-10-01 00:00:00

abstract：:In this study, we assessed the rate of estradiol degradation via the 17 beta-hydroxysteroid dehydrogenase (HSD) enzyme in breast tumors from postmenopausal women. We initially studied the effects of time, level of enzyme activity, amount of tissue assayed, and substrate concentration on the linearity of conversion of ...

journal_title：Steroids

authors： Leszczynski D,Santner SJ,Feil PD,Santen RJ

更新日期：1988-03-01 00:00:00

abstract：:Desoxymethyltestosterone (DMT; 17β-hydroxy-17α-methyl-5α-androst-2-ene) is a designer steroid present in hormonal supplements distributed illegally as such or in combination with other steroids, for self-administration. It figures on the list of substances prohibited in sports and its detection in athlete's urine samp...

journal_title：Steroids

authors： Gauthier J,Poirier D,Ayotte C

更新日期：2012-05-01 00:00:00

abstract：:The isoflavonoids, genistein (4',5,7-trihydroxyisoflavone), biochanin A (5,7-dihydroxy-4'-methoxyisoflavone), daidzein (4',7-dihydroxyisoflavone), and formononetin (7-hydroxy-4'-methoxyisoflavone) are supposed to be health-promoting dietary factors of plant origin. They are particularly abundant in seeds and other par...

journal_title：Steroids

authors： Lapcík O,Hill M,Hampl R,Wähälä K,Adlercreutz H

更新日期：1998-01-01 00:00:00

abstract：:Contraceptive methods for breastfeeding women should be safe for the mother and infant and should not interfere with lactation. Progestin-only methods meet these conditions and can be used from the sixth week postpartum. Because all progestins are excreted in milk, those that are insufficiently active by the oral rout...

journal_title：Steroids

authors： Massai R,Díaz S,Jackanicz T,Croxatto HB

更新日期：2000-10-01 00:00:00

abstract：:A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three can...

journal_title：Steroids

authors： Agarwal DS,Siva Krishna V,Sriram D,Yogeeswari P,Sakhuja R

更新日期：2018-11-01 00:00:00

abstract：:Three new polyhydroxysterols, named muriflasteroids A-C (1-3) were isolated from the South China Sea gorgonian Muriceopsis flavida, together with sixteen known analogs, cholest-3β,5α,6β-triol,3β-acetate (4), 5α-methoxycholest-3β,6β-diol (5), (22E)-cholest-22-en-3β,5α,6β-triol (6), cholest-3β,5α,6β-triol (7), (22E)-24-...

journal_title：Steroids

authors： Liu TF,Lu X,Tang H,Zhang MM,Wang P,Sun P,Liu ZY,Wang ZL,Li L,Rui YC,Li TJ,Zhang W

更新日期：2013-01-01 00:00:00

abstract：:This paper revealed the expression pattern of ERα in the ovoviviparous teleost, Sebastes schlegeli. In this paper, we isolated the cDNA encoding for estrogen receptor alpha of black rockfish (S. schlegeli) from its ovary, named as black rockfish ERα (brfERα). The cDNA sequence of brfERα consists of 2972bp with an open...

journal_title：Steroids

authors： Shi D,Wen HS,He F,Li JF,Yang YP,Chen CF,Zhang JR,Chen XY,Jin GX,Shi B,Qi BX,Li N

更新日期：2011-12-20 00:00:00

abstract：:Inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) regulate the activity of the hypothalamo-pituitary-adrenal (HPA) axis at several levels. Although hypothalamic CRH secretion may be the primary mechanism by which these cytokines activate the HPA axis, IL-1 expression is increased within t...

journal_title：Steroids

authors： Tkachenko IV,Jääskeläinen T,Jääskeläinen J,Palvimo JJ,Voutilainen R

更新日期：2011-09-01 00:00:00

abstract：:Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yie...

journal_title：Steroids

authors： Zhang BL,Zhang E,Pang LP,Song LX,Li YF,Yu B,Liu HM

更新日期：2013-12-11 00:00:00

abstract：:To gain further insight into the mechanism for inactivation of aromatase by androst-5-ene-7,17-dione (1) and its 19-nor analog 4, 10 beta-oxygenated steroids 5 and 6, delta 1(10)-steroid 7, and 19-oxo-5 beta,6 beta-epoxy compound 8 were synthesized and tested for their ability to inhibit aromatase in human placental m...

journal_title：Steroids

authors： Numazawa M,Tachibana M

更新日期：1997-07-01 00:00:00

abstract：:Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...

journal_title：Steroids

authors： Boulch NL,Cancela L,Miravet L

更新日期：1982-04-01 00:00:00

abstract：:21-Hydroxypregnenolone and its metabolite 5-pregnene-3 beta, 20 alpha 21-triol have been measured in the sulfate fraction of neonatal urine. These two steroids are the major two 21-hydroxylated 5-pregnenes produced by neonates and are almost exclusively excreted as disulfates. The excretions of these steroids by norma...

journal_title：Steroids

authors： Shackleton CH,Homoki J,Taylor NF

更新日期：1987-04-01 00:00:00

abstract：:Progesterone and its polar metabolite(s) trigger the meiotic divisions in the amphibian oocyte through a non-genomic signaling system at the plasma membrane. Published site-directed mutagenesis studies of ouabain binding and progesterone-ouabain competition studies indicate that progesterone binds to a 23 amino acid e...

journal_title：Steroids

authors： Morrill GA,Kostellow AB,Askari A

更新日期：2012-09-01 00:00:00

abstract：:Several derivatives of the arthropod moulting hormone have been synthesized which were coupled to AH Sepharose 4B yielding about 2 mumole ligand per g wet gel. As an indication of the suitability of the ligands for biological work the puff inducing capacity of their methyl esters was tested. The methyl ester of inokos...

journal_title：Steroids

authors： Spindler KD,Hamann A,Spindler-Barth M,Ihne A,Beckers C,Emmerich H

更新日期：1976-04-01 00:00:00

abstract：:C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...

journal_title：Steroids

authors： Sholl SA

更新日期：1981-08-01 00:00:00

abstract：:Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-d...

journal_title：Steroids

authors： Baydoun E,Atia-Tul-Wahab,Iqbal S,Smith C,Choudhary MI

更新日期：2017-10-01 00:00:00

abstract：:A time course study to measure adrenal cortical function was undertaken for the period prior to the development of hypertension until the onset of hypertension in the adrenal-regeneration hypertension (ARH) model. Quiescent rat kills were used so that all adrenal cortical parameters investigated would reflect basal or...

journal_title：Steroids

authors： Bergon L,Gallant S,Brownie AC

更新日期：1975-03-01 00:00:00

abstract：:The conversion of testosterone (T) to 5alpha-dihydrotestosterone (DHT) has been demonstrated in Penicillium crustosum broth obtained from fermented pistachios, lemons and corn tortillas. Furthermore, the presence of 5alpha-reductase enzyme, which is responsible for this conversion, has been established by electrophore...

journal_title：Steroids

authors： Flores E,Cabeza M,Quiroz A,Bratoeff E,García G,Ramírez E

更新日期：2003-03-01 00:00:00