Abstract：
:Morphologic changes at the interface of rat endometrial luminal epithelial cells and the stromal cells immediately adjacent were examined and correlated with hypertrophy of the epithelial cells during estradiol (E2) infusion (1 microgram E2/24 h). While the lamina densa in castrate endometrium was thread-like, it became thicker and apparently more granular in some areas below the luminal epithelium during E2 infusion. However, no changes were seen in the intensity of laminin-like immunoreactivity at various time points up to 96 hours after beginning infusion, suggesting that these alterations were due to changes in nonlaminin components. The stromal cells adjacent to the basal lamina in the castrate state had cell processes extending toward the epithelium that terminated on the basal lamina. Under estrogen infusion, stromal cell bodies migrated close to and became oriented along the basal lamina. No interruptions were seen in the lamina densa or in the laminin-like immunoreactivity in the basal lamina. Thus, there were no direct morphologic interactions between epithelial and stromal cells induced by estrogen. Some of the stromal cells developed a dilated rough endoplasmic reticulum and some developed multiple elaborate processes within 41 hours after minipump implantation. Within 28 hours, nuclear hypertrophy had occurred in 15% of the epithelial cell layer. If interactions occur between stromal and epithelial cells, and morphologic evidence presented here suggests they do, then all such interactions are through an intact lamina densa-laminin layer, and any chemical mediators affecting cells on opposite sides of the lamina densa must migrate through it.
journal_name
Steroidsjournal_title
Steroidsauthors
Lavia LA,Larson BAdoi
10.1016/0039-128x(91)90061-ysubject
Has Abstractpub_date
1991-03-01 00:00:00pages
123-30issue
3eissn
0039-128Xissn
1878-5867pii
0039-128X(91)90061-Yjournal_volume
56pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.05.009
更新日期：2011-09-01 00:00:00
abstract：:A significant dose-response relationship between gonadotropin-releasing hormone (GnRH) and time to luteinizing hormone (LH) peak, peak serum LH and total serum LH was obtained in prepubertal Holstein heifers (28 weeks of age) (Experiment 1). For the second experiment, the effect of steroid feedback on the anterior pit...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(86)90082-6
更新日期：1986-02-01 00:00:00
abstract：:The leaky heme mutants G204, G216, and G214 are shown to accumulate exogenous sterols. Unlike hem mutants which have complete blocks in the heme pathway, these strains do not require ergosterol, methionine, or unsaturated fatty acids for growth. The addition of aminolevulinic acid to the growth medium inhibited sterol...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(89)90035-4
更新日期：1989-03-01 00:00:00
abstract：:It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(00)00154-9
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Urinary steroid profiling by GC or GC-MS are established clinical tools to complement other biochemical tests in the diagnosis and investigation of a wide range of adrenocortical disorders, but normative data on adults using the more specific GC-MS are lacking. Our objective was to set up the reference inter...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2008.03.004
更新日期：2008-09-01 00:00:00
abstract：:Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2008.11.017
更新日期：2009-07-01 00:00:00
abstract：:The compounds named in the title have been synthesized from the di-(ethylene ketal) of 21-hydroxy-3,20-dioxo-19-norpregn-5-ene-18, 11 beta-lactone and its 5(10)-ene isomer. Reduction of this mixture 1 with sodium aluminum bis-(methoxyethoxy)hydride furnished the 11 beta, 18, 21-triol 2a. Conversion to the 18,21-diacet...
journal_title：Steroids
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Three BS-BODIPY (brassinosteroids-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) conjugates were synthesized and their fluorescent and immunological properties were investigated. Two of the conjugates, having present all the functional groups characteristic of BS, were shown to be potentially useful as biological probes ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.07.002
更新日期：2015-10-01 00:00:00
abstract：:The steroid hormone dehydroepiandrosterone (DHEA) has beneficial effects on vascular function, survival of neurons, and fatty acid metabolism. However, a specific receptor for DHEA has not been identified to date. Here, we describe the synthesis of a photoreactive DHEA derivative (Photo-DHEA). In Photo-DHEA, typical c...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.01.009
更新日期：2011-04-01 00:00:00
abstract：:The synthesis of (22E,24R)-5 alpha-ergosta-2,22-dien-6-one (2), a key intermediate to the preparation of 24-epibrassinolide (1), was achieved through the 3,6-diketone 8 in a 40% overall yield in five steps starting from ergosterol (3). ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(96)00087-6
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:A high-throughput, sensitive, specific, mass spectrometry-based method for quantitating estrone (E1), estradiol (E2), and testosterone (T) in postmenopausal human serum has been developed for clinical research. The method consumes 100μl human serum for each measurement (triplicates consume 300μl) and does no...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.01.007
更新日期：2015-04-01 00:00:00
abstract：:In the present study the possible dual effects of adenosine as substrate and adenosine receptor agonist in rat granulosa cells, cumulus-oocyte complexes, luteal cells and ovarian membranes are discussed. Adenosine is an indispensable compound in cell energy metabolism, as precursor to cofactors, second messenger and n...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(89)90045-7
更新日期：1989-11-01 00:00:00
abstract：:Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system. Although the MR's closest relative, the glucocorticoid receptor (GR), acts as a transcription factor at the same hormone-response-element (HRE), activated gluco...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2009.10.006
更新日期：2010-08-01 00:00:00
abstract：:The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was t...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.09.007
更新日期：2013-12-11 00:00:00
abstract：:The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90039-4
更新日期：1979-05-01 00:00:00
abstract：:The peripheral conversion of testosterone (T) into androstenedione (delta 4) and dihydrotestosterone (DHT) were studied in pregnant (days 32, 48 and 67 post coitum) and non-pregnant anesthetized guinea-pigs by constant intravenous infusion of tritium labeled T. Endogenous levels were measured by radioimmunoassay, and ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(83)90157-5
更新日期：1983-08-01 00:00:00
abstract：:We describe a convenient and stereoselective route to the synthesis of 27-hydroxycholesterol. Also its radiolabeled analog, 22, 23 di [(3)H]-27-hydroxycholesterol with high specific radioactivity (55 Ci/mmol) was synthesized by this method. Julia condensation of steroidal 22-sulfone with aldehyde, led to the addition ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(00)00099-4
更新日期：2000-07-01 00:00:00
abstract：:The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(00)00114-8
更新日期：2000-10-01 00:00:00
abstract：:The hormone 1alpha,25(OH)2vitamin D3 (1,25-D) produces biological responses via both genomic and rapid mechanisms. The genomic responses are linked to a nuclear receptor, while the rapid responses are believed to utilize other signal transduction pathways that are likely linked to a putative cell membrane receptor for...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/s0039-128x(98)00091-9
更新日期：1999-01-01 00:00:00
abstract：:A series of steroidal and nonsteroidal Michael acceptors that represent reaction products for 3 alpha-hydroxysteroid dehydrogenase were synthesized and evaluated as potential enzyme-generated inactivators. Introduction of exocyclic olefins either at C-2 or C-6 produced inhibitors with high affinity for the enzyme (0.0...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(91)90030-y
更新日期：1991-08-01 00:00:00
abstract：:Synthetic vitamin D3 sulfate was prepared by reacting cholecalciferol with sulfamic acid in pyridine. Vitamin D3 sulfate ammonium salt was purified by crystallisation and transformed in sulfate sodium salt. Homogeneity was controlled by reverse phase high pressure liquid chromatography (HPLC). Purified synthetic vitam...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(82)90063-0
更新日期：1982-04-01 00:00:00
abstract：:Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2008.04.004
更新日期：2008-10-01 00:00:00
abstract：:A series of novel methyl spongoate (1) analogs has been synthesized and evaluated for their in vitro cytotoxic properties. It was found that the nature of the C-20 side chain had significant effects on their bioactivities and some analogs showed higher cytotoxicity than 1 against A549, HCT-116, HepG2, SW-1990, MCF-7 a...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.08.002
更新日期：2010-12-12 00:00:00
abstract：:Estrogen is an important atheroprotective molecule that causes the rapid dilation of blood vessels by stimulating endothelial nitric oxide synthase (eNOS). There is also evidence that estrogen modulates airway epithelial NO production, thereby potentially affecting bronchial hyperresponsiveness. Studies in cultured en...
journal_title：Steroids
pub_type：
doi：10.1016/s0039-128x(98)00105-6
更新日期：1999-01-01 00:00:00
abstract：:Boldenone is an anabolic-androgenic steroid that is prohibited in equine sports. Urine from the uncastrated male horse contains boldenone that is thought to be of endogenous origin and thus a threshold ('cut-off') concentration has been adopted internationally for free and conjugated boldenone to help distinguish case...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2019.03.011
更新日期：2019-06-01 00:00:00
abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.01.003
更新日期：2004-04-01 00:00:00
abstract：:The condensation of O-substituted hydroxylamines with conjugated 3-oxo-4-en steroids results in a mixture of syn-anti configurations. Syn-anti ratios are influenced by sterical hindrance between the oximino substituents (e.g. O-benzyl) and the steroidal skeleton. Stereostructures and isomeric ratios were proved by det...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(98)00111-1
更新日期：1999-04-01 00:00:00
abstract：:Within the adult female, estrogen signaling is well-described as an integral component of the physiologically significant hypothalamic-pituitary-gonadal axis. In rodents, the timing of ovulation is intrinsically entwined with the display of sexual receptivity. For decades, the importance of estradiol activating intrac...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2017.11.013
更新日期：2018-05-01 00:00:00
abstract：:The kinetics of 11 beta-hydroxysteroid dehydrogenase (11HSD) catalyzing the interconversion of cortisol (F) and cortisone (E) were compared in vitro following incubation of homogenates of human (N = 7) and baboon (N = 2) placenta. In both species, enzyme activity catalyzing the conversion of F to E was associated with...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(84)90004-7
更新日期：1984-09-01 00:00:00
abstract：:Gonadal steroids modulate adrenal gland size and function in a variety of species, and our previous studies demonstrate that circulating androgens suppress 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in the adrenal cortex of male mice. The present study tests the hypothesis that androgens have a d...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(02)00023-5
更新日期：2002-07-01 00:00:00
