Abstract:
:The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was transformed in situ into heterocyclic spiran derivatives of 2',3'-ethano-(5α)-cholestane.
journal_name
Steroidsjournal_title
Steroidsauthors
D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UMdoi
10.1016/j.steroids.2013.09.007subject
Has Abstractpub_date
2013-12-11 00:00:00pages
1298-303issue
12-13eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00210-9journal_volume
78pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Labeled beta-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of beta-muri...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90006-6
更新日期:1985-05-01 00:00:00
abstract::Three new polyhydroxysterols, named muriflasteroids A-C (1-3) were isolated from the South China Sea gorgonian Muriceopsis flavida, together with sixteen known analogs, cholest-3β,5α,6β-triol,3β-acetate (4), 5α-methoxycholest-3β,6β-diol (5), (22E)-cholest-22-en-3β,5α,6β-triol (6), cholest-3β,5α,6β-triol (7), (22E)-24-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.10.003
更新日期:2013-01-01 00:00:00
abstract::Morphologic changes at the interface of rat endometrial luminal epithelial cells and the stromal cells immediately adjacent were examined and correlated with hypertrophy of the epithelial cells during estradiol (E2) infusion (1 microgram E2/24 h). While the lamina densa in castrate endometrium was thread-like, it beca...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90061-y
更新日期:1991-03-01 00:00:00
abstract::The potent antiproliferative effect of progestins has been utilized in clinical regimens for treatment of endometrial proliferative disorders. The progestin infiltrated intrauterine device used as therapy for endometrial carcinoma as well as endometrial hyperplasia yields a hundred-fold increase of local progestin con...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.09.010
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Abnormal secretion of thyroid hormones, growth hormone, cortisol and androgens influences body composition. We hypothesised that higher cortisol excretion, in combination with higher androgen and IGF-I concentrations, had a synergistic, favourable effect on body mass and bone. DESIGN, PATIENTS AND METHODS:Th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.09.006
更新日期:2016-11-01 00:00:00
abstract::Extranuclear estrogen receptors may mediate rapid effects of estradiol that communicate with nuclear receptors and contribute to proliferation of human cancers bearing these signaling proteins. To assess these growth-promoting pathways, we undertook controlled homogenization and fractionation of NIH-H23 non-small cell...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.02.017
更新日期:2005-05-01 00:00:00
abstract::Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.003
更新日期:2016-09-01 00:00:00
abstract::Two new polyhydroxysteroids isihippurols A (1) and B (2) were isolated from the MeOH extract of the gorgonian Isis hippuris in addition to nine known steroids namely gorgosterol, 3alpha-acetoxy-24-methyl 11beta,18; 18,20beta; 22,25-triepoxy-5alpha-furostane, hippurin-1, 22-epi-hippuristanol, 22-epi-hippurin-1, 3-acety...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00098-8
更新日期:2001-09-01 00:00:00
abstract::Chick kidney and brain were analyzed for the subcellular distribution (if any) of a putative plasma membrane receptor for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Fractionation protocols were found to be based not only on differential centrifugation conditions, but also gentleness of resuspension procedures, and suffic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00030-6
更新日期:1999-08-01 00:00:00
abstract::Homogenates from human myometrium with an added NADPH regenerating system and ATP were incubated with 4-(14)C progesterone. Six metabolites were identified: 5alpha-pregnane-3, 20-dione, 5beta-pregnane-3, 20-dione, 3alpha-hydroxy-4-pregnen-20-one, 3beta hydroxy-4-pregnen-20-one. 20alpha-hydroxy-4-pregnen-3-one and 20be...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90131-3
更新日期:1977-07-01 00:00:00
abstract::Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90076-8
更新日期:1975-09-01 00:00:00
abstract::A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal dis...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00060-4
更新日期:1995-09-01 00:00:00
abstract::An enzyme immunoassay for estrone in swine serum was established. For this, beta-galactosidase from E. coli was conjugated through estrone-17 (O-carboxymethyl)oxime using a mixed anhydride reaction. The percentage of immunoreactive estrone-17 (O-carboxymethyl)oxime-beta-galactosidase conjugate was estimated to be abou...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90136-2
更新日期:1982-06-01 00:00:00
abstract::The incorporation of the heterocycles into the steroid nucleus has been recognized as a useful strategy to develop new steroidal agents for disease treatment. Representative examples are abiraterone and galeterone, which are presently used in clinic for the treatment of advanced prostate cancers. Herein we have develo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108465
更新日期:2019-11-01 00:00:00
abstract::C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90036-2
更新日期:1981-08-01 00:00:00
abstract::Estrogen plays a central role in the control of reproductive behaviour and in the regulation of neuroendocrine system. To elucidate the mechanism by which it controls the stress-modulated functions, it is important to understand how estrogenic effects are mediated. The distribution of estrogen receptor alpha (ERα) pro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.03.002
更新日期:2019-06-01 00:00:00
abstract::A partial synthesis of the title compound, 4'-(dimethylamino)-17 beta-hydroxy-17 alpha-(1-propynyl)benzo[12,12a]-11 alpha,18-cyclo-12a,12b- dihomo-13 alpha-estr-4-en-3-one 1, is reported. The key step in this synthesis represents an intramolecular alkenylaryl radical cyclization. Treatment of 18-[bromo-5-(dimethylamin...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90026-4
更新日期:1994-03-01 00:00:00
abstract::Allopregnanolone (3α-THP) is one of the main reduced progesterone (P4) metabolites that is recognized as a neuroprotective and myelinating agent. 3α-THP also induces proliferation of different neural cells. It has been shown that P4 favors the progression of glioblastomas (GBM), the most common and aggressive primary ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.01.004
更新日期:2017-03-01 00:00:00
abstract::Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00112-x
更新日期:2001-11-01 00:00:00
abstract::Structural modifications of natural products with complex structures like steroids require great synthetic effort. A review of literature is presented on the chemistry of the steroidal hormone 17α-methyltestosterone that is approved by Food and Drug Administration (FDA) in the United States as an androgen for estrogen...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.11.004
更新日期:2016-01-01 00:00:00
abstract::Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well know...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2009.10.014
更新日期:2010-11-01 00:00:00
abstract::The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2004.11.009
更新日期:2005-03-01 00:00:00
abstract::Some properties of immunoreactive estradiol secreted by adrenals and ovaries of immature female rats were studied. It was shown that adrenals and ovaries of 15-day-old animals secrete approximately equal amounts of immunoreactive estradiol, with thin-layer chromatogram of immunoreactive material being identical for bo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90004-s
更新日期:1992-04-01 00:00:00
abstract::There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2005.02.005
更新日期:2005-05-01 00:00:00
abstract::Explants prepared from the neocortex and the fetal zone of the human fetal adrenal (gestational age 13 to 18weeks) were maintained under conditions of organ culture for 7 to 9 days during which time they were exposed to hACTH and various related peptides. Corticotrophic activity was monitored by the daily release of d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90037-5
更新日期:1978-04-01 00:00:00
abstract::The metabolism of testosterone (T) was studied in normal adult male rats using a constant infusion of trace amounts of the 3H-steroid into a tail vein for 3 h in order to attain a state of equilibrium. Samples of plasma, liver, kidney, prostate, seminal vesicles and muscle were analysed for 3H-testosterone, 3H-5alpha-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90011-2
更新日期:1975-07-01 00:00:00
abstract::Addition of soluble supernatant to testis microsomes results in 42% increase in steroid 17,20-lyase activity and a 65% increase in 17alpha-hydroxylase activity. This stimulatory activity could be partially purified by salt fractionation. The activating factor(s) was not removed by dialysis nor did it appear to be lipi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90090-9
更新日期:1978-10-01 00:00:00
abstract::We report the synthesis of 10 novel steroids obtained from 3 beta, 15 beta-diacetoxy-17 alpha-hydroxy-5-pregnen-20-one (1c) as intermediates in the synthesis of 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-4-pregnen-3-one (6a) and its tritiated tracer 15 beta-acetoxy-20,20-ethylenedioxy-17 alpha-hydroxy-1,2,6,...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00204-8
更新日期:1997-02-01 00:00:00
abstract::A new technique that permits measurement of Androgen-Binding Protein (ABP) is validated by reproducibility, linearity and correlation studies. Using this apparatus allowing Scatchard plot analysis, it is also possible to measure association and dissociation rate constants. In addition, it is a very useful tool for a r...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(88)90174-2
更新日期:1988-10-01 00:00:00
abstract::Within the adult female, estrogen signaling is well-described as an integral component of the physiologically significant hypothalamic-pituitary-gonadal axis. In rodents, the timing of ovulation is intrinsically entwined with the display of sexual receptivity. For decades, the importance of estradiol activating intrac...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2017.11.013
更新日期:2018-05-01 00:00:00