Abstract：
:The metabolism of testosterone (T) was studied in normal adult male rats using a constant infusion of trace amounts of the 3H-steroid into a tail vein for 3 h in order to attain a state of equilibrium. Samples of plasma, liver, kidney, prostate, seminal vesicles and muscle were analysed for 3H-testosterone, 3H-5alpha-dihydrotestosterone (5alphaDHT) and 3H-5alpha-androstanediol (Adiol). When compared to the 3H-T level in plasma there were high levels of 3H-T in kidney and of 3H-5alphaDHT in prostate and seminal vesicles. Intraperitoneal estradiol valerate administration (100 mug/day) for 4 days decreased and 3H-5alphaDHT levels in the prostate and seminal vesicles. The estrogen administration increased the T metabolic clearance rate from 17.5 1/24 h/100 g body wt to 22.6 1/24 h/100 g body wt.
journal_name
Steroidsjournal_title
Steroidsauthors
Lee DK,Bird CE,Clark AFdoi
10.1016/0039-128x(75)90011-2subject
Has Abstractpub_date
1975-07-01 00:00:00pages
137-47issue
1eissn
0039-128Xissn
1878-5867pii
0039-128X(75)90011-2journal_volume
26pub_type
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