Synthesis of new steroidal quinolines with antitumor properties.

abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...

journal_title：Steroids

authors： McGinley R,Casey JH

更新日期：1979-02-01 00:00:00

abstract：:4- to 8-cell mouse PIE's (preimplantation embryos) were cultured in vitro for 48 hr in media containing various concentrations of the anti-estrogen CI-628. Graded effects of the various concentrations were observed with the highest concentration (1.5 microng/ml) being 100% effective in blocking development to the blas...

journal_title：Steroids

authors： Gupta JS,Dey SK,Dickmann Z

更新日期：1977-03-01 00:00:00

abstract：:This review lays out the evidence for the role of E2 in homeostatic and hedonic feeding across several species. While significant effort has been expended on homeostatic feeding research, more studies for hedonic feeding need to be conducted (i.e. are there increases in meal size and enhanced motivation to natural foo...

journal_title：Steroids

authors： Rivera HM,Stincic TL

更新日期：2018-05-01 00:00:00

abstract：:The synthesis of 16 alpha-3H androgens and estrogens is described. 1-(3H)-Acetic acid in the presence of zinc dust reacts with 16 alpha-bromo-17-ketosteroids to produce 16 alpha-3H-17-ketosteroids. This chemical reaction was used to prepare 16 alpha-3H-dehydroepiandrosterone (I) and 16 alpha-3H-estrone acetate (XI) fr...

journal_title：Steroids

authors： Cantineau R,Kremers P,De Graeve J,Cornelis A,Laszlo P,Gielen JE,Lambotte R

更新日期：1981-02-01 00:00:00

abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...

journal_title：Steroids

authors： Zheng QC,Chen GD,Kong MZ,Li GQ,Cui JY,Li XX,Wu ZY,Guo LD,Cen YZ,Zheng YZ,Gao H

更新日期：2013-09-01 00:00:00

abstract：:Based on histological criteria, Kingsley and Bogdanove (3) reported that the benzoate ester of 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT), unlike testosterone propionate, is unable to induce vaginal mucification when given subcutaneously to rats. In contrats, Kennedy (4) found in estrogen-pretreated rats that ...

journal_title：Steroids

authors： Kennedy TG,Armstrong DT

更新日期：1976-03-01 00:00:00

abstract：:The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...

journal_title：Steroids

authors： Higashi T,Miura K,Kikuchi R,Shimada K,Hiyamizu H,Ooi H,Iwabuchi Y,Hatakeyama S,Kubodera N

更新日期：2000-05-01 00:00:00

abstract：:CGS 16949A inhibited the conversion of [4-14C]androstenedione (A) to [4-14C]estrone by human placental microsomes in a competitive manner (Ki = 1.6 nM). Aminoglutethimide, also a competitive inhibitor, had a Ki = 0.7 microM in this assay system. The Km for the aromatization of A was 0.11 microM. Using ovarian microsom...

journal_title：Steroids

authors： Steele RE,Mellor LB,Sawyer WK,Wasvary JM,Browne LJ

更新日期：1987-07-01 00:00:00

abstract：:The functions of the group of proteins known as nuclear receptors will be understood fully only when their working three-dimensional structures are known. These ligand-activated transcription factors belong to the steroid-thyroid-retinoid receptor superfamily, which include the receptors for steroids, thyroid hormone,...

journal_title：Steroids

authors： Kumar R,Thompson EB

更新日期：1999-05-01 00:00:00

abstract：:Estradiol benzoate (EB) has been one of the most widely used estrogenic agents in animal husbandry, as a way of exogenously introducing the natural hormone estradiol-17β into the animal organism. Estradiol was previously employed to induce anabolic effects or reproductive improvements in cattle. However, the employmen...

journal_title：Steroids

authors： Regal P,Nebot C,Díaz-Bao M,Barreiro R,Cepeda A,Fente C

更新日期：2011-03-01 00:00:00

abstract：:Catalytic cycloalumination of (3β,5α)-3-vinylcholestane and (3α,5α)-3-allylcholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give previously unknown aluminacyclopentanes in ∼90% yield; these products were converted in situ to carbo- and heterocyclic (5α)-cholestane derivatives. ...

journal_title：Steroids

authors： D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UM

更新日期：2016-04-01 00:00:00

abstract：:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h)...

journal_title：Steroids

authors： Branchaud CL,Lipowski L,Dhanani B,Goodyer CG,Lefebvre Y

更新日期：1986-04-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone involved in a number of biological actions in humans and rodents, but its effects on renal tissue have not yet been fully understood. The aim of this study is to assess the effect of DHEA treatment on diabetic rats, mainly in relation to renal function and...

journal_title：Steroids

authors： Jahn MP,Gomes LF,Jacob MH,da Rocha Janner D,Araújo AS,Belló-Klein A,Ribeiro MF,Kucharski LC

更新日期：2011-05-01 00:00:00

abstract：:Sphenocentrum jollyanum seeds (MeOH extract and n butanol fraction) exhibited urease inhibitory activity (IC50 40.0 ± 0.92, 28.6 ± 0.41). The Ethyl acetate (EtOAc) fraction gave significant antacid activity with an increase in the baseline pH value of 1.2 to 1.61 ± 0.00 and 1.53 ± 0.00 at 50 and 100 mg, respectively, ...

journal_title：Steroids

authors： Akinwumi IA,Sonibare MA,Yeye EO,Khan M

更新日期：2020-07-01 00:00:00

abstract：:The effect of steroids contained in oral contraceptives, namely ethinylestradiol:17 alpha-ethinyl-1,3,5,(10)-estratriene-3, 17-diol (E) and norethindrone acetate:17 beta-acetoxy-17-ethinyl-4-estren-3-one (N), on cell replication and human chorionic gonadotropin (hCG) secretion by choriocarcinoma cells in monolayer cul...

journal_title：Steroids

authors： Gal D,Simpson ER,Porter JC,MacDonald PC,Buchsbaum HJ

更新日期：1981-06-01 00:00:00

abstract：:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...

journal_title：Steroids

authors： Wang C,Zhao M,Yang J,Peng S

更新日期：2001-11-01 00:00:00

abstract：:17 beta-Hydroxysteroid dehydrogenase (HSD) was studied in endometrium removed surgically from intact female monkeys in the luteal phase of the menstrual cycle. Also castrated monkeys (N=20) implanted with estradiol (E2) and progesterone (P) in silastic capsules were used to investigate the hormonal dependence of this ...

journal_title：Steroids

authors： Kreitmann O,Kreitmann-Gimbal B,Bayard F,Hodgen GD

更新日期：1979-01-01 00:00:00

abstract：:Estrogen is an important atheroprotective molecule that causes the rapid dilation of blood vessels by stimulating endothelial nitric oxide synthase (eNOS). There is also evidence that estrogen modulates airway epithelial NO production, thereby potentially affecting bronchial hyperresponsiveness. Studies in cultured en...

journal_title：Steroids

authors： Shaul PW

更新日期：1999-01-01 00:00:00

abstract：:The enterohepatic circulation and metabolism of ethynodiol diacetate (3beta,17beta-diacetoxy-17alpha-ethynyl-estr-4-ene) in baboons were studied following the intravenous injection of this contraceptive steroid labeled with 14C (4-position) and with 3H (in either the 3- or 17-acetoxy moieties). Bile and urine from fou...

journal_title：Steroids

authors： Ishihara M,Osawa Y,Kirdani RY,Sandberg AA

更新日期：1975-06-01 00:00:00

abstract：:Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...

journal_title：Steroids

authors： Grainger WS,Parish EJ

更新日期：2015-09-01 00:00:00

abstract：:Two dimeric steroidal terephthalates derived from epimeric 4,5-seco-cholest-3-yn-5-ols were prepared starting from cholesterol in a five-step synthetic sequence. X-ray crystallography shows that the obtained compounds display novel supramolecular networks in the solid state in which the facial hydrophobicity of the st...

journal_title：Steroids

authors： Alarcón-Manjarrez C,Arcos-Ramos R,Álamo MF,Iglesias-Arteaga MA

更新日期：2016-05-01 00:00:00

abstract：:Addition of soluble supernatant to testis microsomes results in 42% increase in steroid 17,20-lyase activity and a 65% increase in 17alpha-hydroxylase activity. This stimulatory activity could be partially purified by salt fractionation. The activating factor(s) was not removed by dialysis nor did it appear to be lipi...

journal_title：Steroids

authors： Betz G,Tsai P

更新日期：1978-10-01 00:00:00

abstract：:By analyzing the steroidal content of fresh whole plants of Tacca subflabellata (Taccaceae), we isolated one sapogenin and eight glycosides with four kinds of steroidal skeletons including four new glycosides, named taccasubosides A-D (1-4), together with five known compounds. Among them, compound 1 is the first penta...

journal_title：Steroids

authors： Li L,Ni W,Li XR,Hua Y,Fang PL,Kong LM,Pan LL,Li Y,Chen CX,Liu HY

更新日期：2011-09-01 00:00:00

abstract：:A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of...

journal_title：Steroids

authors： Ohnuma N,Kiyoki M,Bannai K,Naruchi T,Hashimoto Y,Noguchi T,Norman AW

更新日期：1980-07-01 00:00:00

abstract：:The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...

journal_title：Steroids

authors： Solaja BA,Dermanović M,Lim DM,Paik YK,Tinant B,Declerq JP

更新日期：1997-11-01 00:00:00

abstract：:The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...

journal_title：Steroids

authors： Pérez-de-Heredia F,Sánchez J,Priego T,Nicolás F,Portillo Mdel P,Palou A,Zamora S,Garaulet M

更新日期：2008-10-01 00:00:00

abstract：:Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...

journal_title：Steroids

authors： Ekhato IV,Hurley T,Lovdahl M,Revitte TJ,Guo L,Huang Y,Clipper S,Colson C

更新日期：2002-03-01 00:00:00

abstract：:Estradiol (E2), progesterone (P4), and oxytocin (OT) are important for the initiation of luteolysis in ruminants but the mechanisms involved are still poorly understood. The objective of this study was to determine if duration of exposure of bovine endometrial epithelial cells to P4 affected the response of the cells ...

journal_title：Steroids

authors： Kombé A,Sirois J,Goff AK

更新日期：2003-09-01 00:00:00

abstract：:The purpose of this study was to determine the short-term effects of progesterone action on estrogen receptor (Re) levels in the rat uterus. Ovariectomized, adrenalectomized rats were maintained on subcutaneous Silastic implants containing crystalline estradiol. Progesterone treatment with serum estradiol maintenance ...

journal_title：Steroids

authors： Okulicz WC,Evans RW,Leavitt WW

更新日期：1981-04-01 00:00:00

abstract：:The binding characteristics and quantitation of the recently reported fetal steroid binding protein (FSBP) cannot be determined on unpurified samples; an immunoassay was therefore desirable. The protein was purified to homogeneity in order to raise a highly specific polyclonal antibody. An enzyme-linked immunosorbent ...

journal_title：Steroids

authors： Iqbal MJ,Forbes A,Corbishley TP,Wilkinson ML,Williams R

更新日期：1985-01-01 00:00:00