Alterations in the androgen metabolism of the female guinea-pig during pregnancy.

abstract：:7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers ...

journal_title：Steroids

authors： Duval D,Prédine J,Emiliozzi R,Milgrom E

更新日期：1980-01-01 00:00:00

abstract：:Evaluation of sex steroids in cervical mucus was performed at different phases of spontaneous or clomiphene-citrate-induced ovulatory cycles. To this end, 11 women with normal ovulatory cycles and 9 subjects with polycystic ovary syndrome of comparable age and body mass index were investigated. Serum and cervical mucu...

journal_title：Steroids

authors： Adamopoulos DA,Kapolla N,Abrahamian A,Dessypris A,Nicopoulou S,Giannacodemos G

更新日期：2000-01-01 00:00:00

abstract：:Brassinosteroids (BRs) are steroid hormones regulating various aspects of plant metabolism, including growth, development and stress responses. However, little is known about the mechanism of their impact on antioxidant systems and phospholipid turnover. Using tobacco plants overexpressing H+/Ca2+vacuolar Arabidopsis ...

journal_title：Steroids

authors： Kretynin SV,Kolesnikov YS,Derevyanchuk MV,Kalachova TA,Blume YB,Khripach VA,Kravets VS

更新日期：2019-07-08 00:00:00

abstract：:We have previously demonstrated that 1α,25 dihydroxy-vitamin D(3) (1α,25(OH)(2)D(3)) has antiproliferative effects on the growth of endothelial cells transformed by the viral G protein-coupled receptor associated to Kaposi sarcoma (vGPCR). In this work, we have investigated whether 1α,25(OH)(2)D(3) exerts its growth i...

journal_title：Steroids

authors： Gonzalez-Pardo V,D'Elia N,Verstuyf A,Boland R,Russo de Boland A

更新日期：2012-09-01 00:00:00

abstract：:During the periparturient period, dairy cows are subjected to physiological changes that may induce immunosuppression and an increased susceptibility of the animal to bacterial infections such as mastitis. The incidence of clinical environmental mastitis is high during the last period of gestation, at parturition and ...

journal_title：Steroids

authors： Winters KR,Meyer E,Van Merris VM,Van Den Broeck WL,Duchateau L,Burvenich C

更新日期：2003-05-01 00:00:00

abstract：:A new synthetic pathway towards secosteroidal macrocycles was described via a reaction of cycloaddition as the key step. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported. ...

journal_title：Steroids

authors： Ibrahim-Ouali M,Hamze K

更新日期：2014-02-01 00:00:00

abstract：:We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3 beta, 22-diol-3 beta-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3 beta-acetate 3 and (E) 22-dehydrocholest-5-en-3 beta-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixture of the ...

journal_title：Steroids

authors： Gill HS,Londowski JM,Corradino RA,Kumar R

更新日期：1986-07-01 00:00:00

abstract：:Early work in the field established that the 5 alpha-reduced metabolite of progesterone 3 alpha-OH-5 alpha-pregnan-20-one (allopregnanolone or 3 alpha,5 alpha-THP) is a potent positive modulator of the GABA(A) receptor (GABAR), the receptor mediating the effects of the primary inhibitory transmitter in the brain. This...

journal_title：Steroids

authors： Smith SS

更新日期：2002-05-01 00:00:00

abstract：:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h)...

journal_title：Steroids

authors： Branchaud CL,Lipowski L,Dhanani B,Goodyer CG,Lefebvre Y

更新日期：1986-04-01 00:00:00

abstract：:This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...

journal_title：Steroids

authors： Wu EX,Tang H,Tong C,Heymsfield SB,Vasselli JR

更新日期：2008-04-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...

journal_title：Steroids

authors： Huerta-García E,Ventura-Gallegos JL,Victoriano ME,Montiél-Dávalos A,Tinoco-Jaramillo G,López-Marure R

更新日期：2012-02-01 00:00:00

abstract：:21-Hydroxypregnenolone and its metabolite 5-pregnene-3 beta, 20 alpha 21-triol have been measured in the sulfate fraction of neonatal urine. These two steroids are the major two 21-hydroxylated 5-pregnenes produced by neonates and are almost exclusively excreted as disulfates. The excretions of these steroids by norma...

journal_title：Steroids

authors： Shackleton CH,Homoki J,Taylor NF

更新日期：1987-04-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrine problem affecting women of reproductive age and is investigated from many regions of the world. Some reports have indicated ethnic difference in its manifestation. This review addressed the evidences for ethnic variation in the expression of PCOS phenotypes...

journal_title：Steroids

authors： Zhao Y,Qiao J

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...

journal_title：Steroids

authors： de Oliveira C,Iwanaga-Carvalho C,Mota JF,Oyama LM,Ribeiro EB,Oller do Nascimento CM

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Estrogen replacement therapy increases risk for ovarian epithelial cancer, a cancer of mainly older women, yet the response of older ovarian surface epithelium (OSE) to repeat estrogen exposure overtime has not been studied. We have previously reported significant reductions in estrogen receptor (ER) protein...

journal_title：Steroids

authors： Gulliver LS,Hurst PR

更新日期：2012-05-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type II enzyme (11 beta HSD2) converts cortisol to cortisone, allowing the non-selective mineralocorticoid receptor to bind aldosterone. When the activity of this enzyme is compromised, as occurs in licorice intoxication or in the congenital syndrome of apparent mineralocortico...

journal_title：Steroids

authors： Ferrari P,Obeyesekere VR,Li K,Andrews RK,Krozowski ZS

更新日期：1996-04-01 00:00:00

abstract：:Gypensapogenin H (GH) is a novel dammarane-type triterpenes obtained from hydrolyzate of total saponins from Gynostemma pentaphyllum and its anti-tumor activity has been studied in previous work. In this study, we report the effects of this compound on human prostate cancer cells (DU145 and 22RV-1). It significantly i...

journal_title：Steroids

authors： Zhang XS,Zhao C,Tang WZ,Wu XJ,Zhao YQ

更新日期：2015-12-01 00:00:00

abstract：:Circulating human lymphocytes are known to contain specific glucocorticoid receptors. Using a competitive binding whole cell assay, we have examined the binding of [3H] dexamethasone to peripheral lymphocytes of normal male subjects. Lymphocytes were found to contain 2000-10000 glucocorticoid receptor sites/cell and t...

journal_title：Steroids

authors： Schlaghecke R,Kley HK

更新日期：1986-04-01 00:00:00

abstract：:The crystal and molecular structure of 3-methoxy-9(10 leads to 19)abeo-1,3,5(10)-estratrien-17-one has been determined by X-ray analysis in order to ascertain the configuration at C(9). The seven-membered B-ring has a chair conformation and this causes the molecule to bow towards the alpha-face rather than towards the...

journal_title：Steroids

authors： Weeks CM,Rohrer DC,Duax WL

更新日期：1976-02-01 00:00:00

abstract：:Besides regulating water and electrolyte homeostasis, the mineralocorticoid receptor (MR) elicits pathophysiological effects in the renocardiovascular system. Although the MR's closest relative, the glucocorticoid receptor (GR), acts as a transcription factor at the same hormone-response-element (HRE), activated gluco...

journal_title：Steroids

authors： Grossmann C,Ruhs S,Seiferth A,Gekle M

更新日期：2010-08-01 00:00:00

abstract：:The binding characteristics and quantitation of the recently reported fetal steroid binding protein (FSBP) cannot be determined on unpurified samples; an immunoassay was therefore desirable. The protein was purified to homogeneity in order to raise a highly specific polyclonal antibody. An enzyme-linked immunosorbent ...

journal_title：Steroids

authors： Iqbal MJ,Forbes A,Corbishley TP,Wilkinson ML,Williams R

更新日期：1985-01-01 00:00:00

abstract：:Significant changes in % free serum E2, T and P were observed during the annual cycle of the turtle. In contrast no significant changes in SHBG affinity constants (2.29-4.48 x 10(8) M-7) were found and binding capacity for estradiol 17B was between 3.47 and 3.96 x 10(-7) M except in preovulatory animals (2.00 +/- 0.25...

journal_title：Steroids

authors： Albert C,Callard IP

更新日期：1988-10-01 00:00:00

abstract：:(24R and 24S)-5beta-cholestane-3alpha,7alpha,24,25-tetrols were prepared by osmium tetroxide oxidation of 5beta-cholest-24-ene-3alpha,7alpha-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and ...

journal_title：Steroids

authors： Batta AK,Dayal B,Tint GS,Shefer S,Toome V,Salen G,Mosbach EH

更新日期：1978-01-01 00:00:00

abstract：:The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membran...

journal_title：Steroids

authors： Castelnovo LF,Magnaghi V,Thomas P

更新日期：2019-02-01 00:00:00

abstract：:The effect of steroids contained in oral contraceptives, namely ethinylestradiol:17 alpha-ethinyl-1,3,5,(10)-estratriene-3, 17-diol (E) and norethindrone acetate:17 beta-acetoxy-17-ethinyl-4-estren-3-one (N), on cell replication and human chorionic gonadotropin (hCG) secretion by choriocarcinoma cells in monolayer cul...

journal_title：Steroids

authors： Gal D,Simpson ER,Porter JC,MacDonald PC,Buchsbaum HJ

更新日期：1981-06-01 00:00:00

abstract：:Oleoyl-estrone (OE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of t...

journal_title：Steroids

authors： Romero Mdel M,Vilà R,Fernández-López JA,Esteve M,Alemany M

更新日期：2010-01-01 00:00:00

abstract：:Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. At 0 degrees C apparent equilibrium of ...

journal_title：Steroids

authors： Zakár T,Tóth M

更新日期：1977-12-01 00:00:00

abstract：:Gene therapy based on gene delivery is a promising strategy for the treatment of various human diseases such as cancer. Cationic lipids represent one of the important synthetic gene delivery systems. There is a great interest in imaging of gene therapy using the biomedical imaging technique positron emission tomograph...

journal_title：Steroids

authors： Gao M,Wang M,Miller KD,Sledge GW,Hutchins GD,Zheng QH

更新日期：2010-10-01 00:00:00

abstract：:Chick kidney and brain were analyzed for the subcellular distribution (if any) of a putative plasma membrane receptor for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Fractionation protocols were found to be based not only on differential centrifugation conditions, but also gentleness of resuspension procedures, and suffic...

journal_title：Steroids

authors： Jia Z,Nemere I

更新日期：1999-08-01 00:00:00

abstract：:Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (...

journal_title：Steroids

authors： Popadyuk II,Markov AV,Morozova EA,Babich VO,Salomatina OV,Logashenko EB,Zenkova MA,Tolstikova TG,Salakhutdinov NF

更新日期：2017-11-01 00:00:00