Abstract:
:The effect of steroids contained in oral contraceptives, namely ethinylestradiol:17 alpha-ethinyl-1,3,5,(10)-estratriene-3, 17-diol (E) and norethindrone acetate:17 beta-acetoxy-17-ethinyl-4-estren-3-one (N), on cell replication and human chorionic gonadotropin (hCG) secretion by choriocarcinoma cells in monolayer culture and by hydatidiform mole tissue maintained in organ culture were studied. The steroids were added to the culture medium individually or in combination to achieve a range of concentrations (10-10 to 10-4), within and beyond the presumed concentration of these substances in the blood of women taking oral contraceptives. The effect of luteinizing hormone releasing hormone (LHRH) on hCG secretion by choriocarcinoma cells in monolayer culture also was investigated. The rate of hCG production by either choriocarcinoma cells in monolayer culture or by hydatidiform mole tissue maintained in organ culture was not affected by the hormones used in this study; indeed hCG secretion remained reasonably unchanged even with high concentrations of steroids (up to 10-4 M) or LHRH (up to 10-4 mg x ml-1). Cell replication, as measured by increase in amount of cellular protein and DNA, was not stimulated by either of these compounds.
journal_name
Steroidsjournal_title
Steroidsauthors
Gal D,Simpson ER,Porter JC,MacDonald PC,Buchsbaum HJdoi
10.1016/s0039-128x(81)90197-5subject
Has Abstractpub_date
1981-06-01 00:00:00pages
663-71issue
6eissn
0039-128Xissn
1878-5867pii
S0039-128X(81)90197-5journal_volume
37pub_type
杂志文章相关文献
STEROIDS文献大全abstract::There are quite substantial number of impurities related to dexamethasone or mometasone which cannot be made from respective Active Pharmaceutical Ingredients but from common intermediate 21-acetoxy-17α-hydroxy-16α-methyl-pregna-1,4,9(11)-triene-3,20-dione (12). As such, a robust and economical synthesis of this key i...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.04.008
更新日期:2019-08-01 00:00:00
abstract::21-Hydroxypregnenolone and its metabolite 5-pregnene-3 beta, 20 alpha 21-triol have been measured in the sulfate fraction of neonatal urine. These two steroids are the major two 21-hydroxylated 5-pregnenes produced by neonates and are almost exclusively excreted as disulfates. The excretions of these steroids by norma...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(87)90006-7
更新日期:1987-04-01 00:00:00
abstract::The 1,3-dipolar cycloaddition of azomethine ylide derived in situ from the reaction of acenaphthylene-1,2-dione and 1,3-thiazolane-4-carboxylic acid to various exocyclic dipolarophiles synthesized from trans-androsterone and trans-dehydroandrosterone afforded a library of novel spiro[5'.2″]acenaphthylene-1″-one-spiro[...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.12.017
更新日期:2013-04-01 00:00:00
abstract::Three BS-BODIPY (brassinosteroids-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) conjugates were synthesized and their fluorescent and immunological properties were investigated. Two of the conjugates, having present all the functional groups characteristic of BS, were shown to be potentially useful as biological probes ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.07.002
更新日期:2015-10-01 00:00:00
abstract::A radioimmunoassay for plasma 3 beta, 7 alpha-dihydroxy-5-androsten-17-one (7 alpha-hydroxy DHA) has been developed using anti-sera raised against 3 beta, 7 alpha-dihydroxy-5-androstene-17 beta-carboxyl-bovine serum albumin conjugate and [1, 2 (n) - 3H] 7 alpha-hydroxy DHA as the radioligand. Significant cross reactiv...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90023-x
更新日期:1977-09-01 00:00:00
abstract::The applications of sterically crowed trialkyksilyl ether derivatives to the analysis and characterization by thin-layer chromatography, gas chromatography and mass spectrometry, of metabolites of 2alpha, 3alpha-cyclopropano-5alpha-androstan-17beta-ol in the rabbit are described. These derivatives are complementary to...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90013-7
更新日期:1977-05-01 00:00:00
abstract::A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trilliu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.10.013
更新日期:2015-12-01 00:00:00
abstract::The full assignments of the (1)H and (13)C NMR signals of steroids bearing the 16beta,23:23,26-diepoxy side chain are provided. Differentiation of the diasterotopic H-26 pair was achieved with the aid of NOESY experiments. The main substituent and steric effects associated with this moiety and their influence on the c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.01.027
更新日期:2008-07-01 00:00:00
abstract::Gonadal steroids modulate adrenal gland size and function in a variety of species, and our previous studies demonstrate that circulating androgens suppress 3beta-hydroxysteroid dehydrogenase-isomerase (3betaHSD) activity in the adrenal cortex of male mice. The present study tests the hypothesis that androgens have a d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00023-5
更新日期:2002-07-01 00:00:00
abstract::The leaky heme mutants G204, G216, and G214 are shown to accumulate exogenous sterols. Unlike hem mutants which have complete blocks in the heme pathway, these strains do not require ergosterol, methionine, or unsaturated fatty acids for growth. The addition of aminolevulinic acid to the growth medium inhibited sterol...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90035-4
更新日期:1989-03-01 00:00:00
abstract::The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the s...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90107-5
更新日期:1975-12-01 00:00:00
abstract::Using beta-sitosterol as a starting material, (6E)-hydroximino-24-ethylcholest-4-en-3-one (1), a natural steroidal oxime from Cinachyrella alloclada and C. apion, was synthesized in four steps with a high overall yield. First, beta-sitosterol (5a) is transformed into the corresponding 24-ethylcholest-4-en-3,6-dione (6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.10.007
更新日期:2008-03-01 00:00:00
abstract::Steroids with 4-ene-3,6-dione functionality have application in natural product chemistry, as synthetic intermediates and as aromatase inhibitors. Here, we report a two-phase oxidation of a range of steroidal 5-en-3beta-ols into corresponding 4-ene-3,6-diones using a modified Jones oxidation. The new reaction affords ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2005.07.007
更新日期:2006-01-01 00:00:00
abstract::A trisulfated derivative of 24,25,26,26-tetramethyl-5 alpha-cholest-23E-ene-2 alpha, 3 beta, 6 alpha-triol (sokotrasterol sulfate) has been isolated from the sponge Halichondriidae gen. sp., collected near Sokotra Island (Arabian Sea), and its structure has been elucidated. The side chain of the new steroid involves a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90039-9
更新日期:1983-09-01 00:00:00
abstract::Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.11.005
更新日期:2016-01-01 00:00:00
abstract::13beta-Ethyl-3-methoxy-17beta-ol-8,14-seco-1,3,5(10),8-gonatetraen-14-one (IIIa) was isolated and its participation in the well-known acidic cyclization process was established. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90015-x
更新日期:1975-05-01 00:00:00
abstract::We recently characterized the awakening responses and daily profiles of the catabolic stress hormone cortisol in elite military men. Anabolic hormones follow a similar daily pattern and may counteract the catabolic effects of cortisol. This companion report is the first to characterize daily profiles of anabolic hormo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.04.001
更新日期:2016-06-01 00:00:00
abstract::Data in animal models and surveys in humans have revealed psychiatric complications of long-term anabolic androgenic steroid abuse. However, the neurobiochemical mechanisms behind the observed behavioral changes are poorly understood. The aim of the present study was to investigate the effects of nandrolone decanoate ...
journal_title:Steroids
pub_type: 杂志文章
doi:
更新日期:2014-01-01 00:00:00
abstract::Two variants of the Claisen rearrangement were evaluated for a stereoselective construction of a C-25 stereogenic center in cholestenoic acids based on 1,4-chirality transfer. Johnson orthoester Claisen rearrangement of (22R)- and (22S)-propargyl enol ethers proceeded in a highly stereoselective manner to give (25R)- ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.03.006
更新日期:2013-07-01 00:00:00
abstract::Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-d...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2017.07.010
更新日期:2017-10-01 00:00:00
abstract::A radio-gas chromatographic method has been devised for the estimation of 11-oxotestosterone (17beta-hydroxyandrost-4-ene-3, 11-dione) in fish plasma samples which provides an independent means of validating the radioimmunoassay described earlier. Estimates of the concentration of 11-oxotestosterone in a sample of mal...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(78)80009-9
更新日期:1978-05-01 00:00:00
abstract::Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(81)80020-7
更新日期:1981-02-01 00:00:00
abstract::The kinetics of 11 beta-hydroxysteroid dehydrogenase (11HSD) catalyzing the interconversion of cortisol (F) and cortisone (E) were compared in vitro following incubation of homogenates of human (N = 7) and baboon (N = 2) placenta. In both species, enzyme activity catalyzing the conversion of F to E was associated with...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(84)90004-7
更新日期:1984-09-01 00:00:00
abstract::Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.004
更新日期:2008-10-01 00:00:00
abstract::Glucocorticoids are important regulators of metabolism and immune function. Synthetic glucocorticoids are extensively used for immunosuppression/anti-inflammatory therapy. Since the glucocorticoid receptor (GR) is central to most hormone effects; its in vivo regulation will influence hormone/drug action. An alternativ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.11.014
更新日期:2013-02-01 00:00:00
abstract::Steroid research at Lederle was initiated in 1946 and continued until about 1971. The areas of research interest involved primarily a study of delta 5,7-steroids, provitamin D3 variants, dehydroepiandrosterone variants, steroidal ketals, corticoids, and steroid conjugates. One of the principal goals was to develop nov...
journal_title:Steroids
pub_type: 历史文章,杂志文章
doi:10.1016/0039-128x(92)90083-l
更新日期:1992-08-01 00:00:00
abstract::Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Thus, inhibitors...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00044-0
更新日期:1998-07-01 00:00:00
abstract::The hepatic metabolism of 3-oxoandrost-4-ene-17 beta-carboxylic acid (etienic acid), a probable acidic catabolite of deoxycorticosterone, was investigated using rats prepared with an external biliary fistula. Metabolic products were identified by GC-MS after hydrolysis with beta-glucuronidase and by proton nuclear mag...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90052-b
更新日期:1992-07-01 00:00:00
abstract::The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00114-8
更新日期:2000-10-01 00:00:00
abstract::Synthesis of 7-aryl/allyl-substituted androstene derivatives 3a through 3g has been carried out by Grignard reaction on 3 beta,17 beta-diacetoxyandrost-5-en-7-one (2) with aryl/allyl magnesium bromide. Isomeric mixture of products 3b and 3c/3e and 3f/3h was separated by column chromatography. Stereochemical assignment...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90005-g
更新日期:1991-09-01 00:00:00