Abstract:
:Biotransformation of an orally active contraceptive drug, drospirenone (1), by Cunninghamella elegans ATCC 36114 yielded four new metabolites, 6β,7β,15β,16β-dimethylene-3-oxo-14α-hydroxy-17α-pregn-4-ene-21,17-carbolactone (2), 6β,7β,15β,16β-dimethylene-3,11-dioxo-17α-pregn-4-ene-21,17-carbolactone (3), 6β,7β,15β,16β-dimethylene-3,12-dioxo-17α-pregn-4-ene-21,17-carbolactone (4), and 6β,7β,15β,16β-dimethylene-3-oxo-11β,14α-dihydroxy-17α-pregn-4-ene-21,17-carbolactone (5), along with a known metabolite, 6β,7β,15β,16β-dimethylene-3-oxo-11α-dihydroxy-17α-pregn-4-ene-21,17-carbolactone (6). This study provides not only new analogues of orally active contraceptive drug, drospirenone, but also help in understanding the metabolism of this important drug.
journal_name
Steroidsjournal_title
Steroidsauthors
Baydoun E,Atia-Tul-Wahab,Iqbal S,Smith C,Choudhary MIdoi
10.1016/j.steroids.2017.07.010subject
Has Abstractpub_date
2017-10-01 00:00:00pages
30-34eissn
0039-128Xissn
1878-5867pii
S0039-128X(17)30132-0journal_volume
126pub_type
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