Abstract：
:The structure of dehydro-oogoniol (3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one), a female-activating hormone of the water mold Achlya, has been confirmed by synthesis. The starting material was progesterone, which was converted to the 11 alpha, 15 beta-dihydroxy derivative by microbiological hydroxylation with Aspergillus giganteus (ATCC 10059). The side chain was constructed in a stepwise manner by means of Wittig and Horner-Emmons reactions, and the C-7 ketone was then introduced by allylic oxidation. The biological activity of the synthetic compound was the same as that of the natural hormone.
journal_name
Steroidsjournal_title
Steroidsauthors
McMorris TC,Le PH,Preus MW,Schow SR,Weihe GRdoi
10.1016/0039-128x(89)90019-6subject
Has Abstractpub_date
1989-03-01 00:00:00pages
345-61issue
3-5eissn
0039-128Xissn
1878-5867pii
0039-128X(89)90019-6journal_volume
53pub_type
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