Abstract:
:From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compound 2 has been previously isolated from Euphorbia chamaesyce while compound 3 was never reported before. The isolated compounds 1-4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacological tests on the more active compounds 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells.
journal_name
Steroidsjournal_title
Steroidsauthors
Aghaei M,Yazdiniapour Z,Ghanadian M,Zolfaghari B,Lanzotti V,Mirsafaee Vdoi
10.1016/j.steroids.2016.07.008subject
Has Abstractpub_date
2016-11-01 00:00:00pages
90-97eissn
0039-128Xissn
1878-5867pii
S0039-128X(16)30085-Xjournal_volume
115pub_type
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