Abstract:
:Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and comparison with the literature data. The cytotoxicities in vitro against three selected human tumor cell lines for all the compounds were evaluated. Compound 9 showed significant cytotoxicities toward both K562 and MDA-MB-231 cell lines with IC50 values of 5.5 and 6.2μM, respectively, and compound 10 also showed inhibitory activity against K562 cell line with an IC50 value of 6.5μM.
journal_name
Steroidsjournal_title
Steroidsauthors
Zhang G,Tang X,Cheng C,Gong K,Zhang X,Zhu H,Wu R,Li P,Li Gdoi
10.1016/j.steroids.2013.05.009subject
Has Abstractpub_date
2013-09-01 00:00:00pages
845-50issue
9eissn
0039-128Xissn
1878-5867pii
S0039-128X(13)00109-8journal_volume
78pub_type
杂志文章相关文献
STEROIDS文献大全abstract::The crystal and molecular structure of 3-methoxy-9(10 leads to 19)abeo-1,3,5(10)-estratrien-17-one has been determined by X-ray analysis in order to ascertain the configuration at C(9). The seven-membered B-ring has a chair conformation and this causes the molecule to bow towards the alpha-face rather than towards the...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(76)90102-1
更新日期:1976-02-01 00:00:00
abstract::A series of novel 5α, 8α-endoperoxide steroidal hybrid derivatives containing isatin or indole substituents on the C-17 side chain were synthesized and characterized. The preliminary anti-proliferative activity of the compounds against HepG2, MCF-7, HT-29 and HeLa cell lines were investigated. Compounds 7g and 7l disp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108471
更新日期:2020-01-01 00:00:00
abstract::The conjugation reactions of hydration and dehydrogenation catalyzed by the dehydratase and dehydrogenase activities of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein (DBP) and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase bifunctional protein (LBP) in the side chain degra...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00217-8
更新日期:2001-02-01 00:00:00
abstract::We investigated the modulatory effect of estriol (E(3)), an estrogen predominantly produced during human pregnancy, on the antigen-induced production of specific antibodies in female BALB/c mice, and its effect was compared with 17beta-estradiol (E(2)). Estriol (E(3)) had a very different effect than E(2) on the antig...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.10.012
更新日期:2008-03-01 00:00:00
abstract::Brassinosteroid (BR) phytohormones play indispensable roles in plant growth and development. Brassinolide (BL) and 24-epibrassinolide (24-epiBL) are the most active ones among the BRs reported thus far. Unfortunately, the extremely low natural content and intricate synthesis process limit their popularization in agric...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.09.002
更新日期:2015-12-01 00:00:00
abstract::The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/0039-128x(90)90012-z
更新日期:1990-10-01 00:00:00
abstract::The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(82)90018-6
更新日期:1982-10-01 00:00:00
abstract::From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2-3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2016.07.008
更新日期:2016-11-01 00:00:00
abstract::Agave plants are popular for their myriad applications in traditional medicine attributed to their reported anti-inflammatory, immunomodulatory, cytotoxic and antifungal activities. The aim of this study was to examine the anti-inflammatory, immunomodulatory and ulceroprotective activity of Agave species in relation t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2020.108648
更新日期:2020-08-01 00:00:00
abstract::Mass spectra and fragmentation patterns of the epimeric 17-, 16-, 15- and 14-hydroxy derivatives of 3-methoxy-1,3,5(10)-estratriene are compared. The main fragmentation pathways are differently influenced, depending on the position of the hydroxy group. The different configuration of the hydroxy groups is reflected on...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90077-x
更新日期:1980-11-01 00:00:00
abstract::(24R and 24S)-5beta-cholestane-3alpha,7alpha,24,25-tetrols were prepared by osmium tetroxide oxidation of 5beta-cholest-24-ene-3alpha,7alpha-diol. The resulting diastereomeric tetrols were separated by thin-layer chromatography, their purity ascertained by melting point, gas-liquid chromatography and mass spectra and ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90022-3
更新日期:1978-01-01 00:00:00
abstract::To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.12.005
更新日期:2014-04-01 00:00:00
abstract::Steroid hormones are involved in the regulation of a variety of processes like embryonic development, sex differentiation, metabolism, immune responses, circadian rhythms, stress response, and reproduction in vertebrates. Teleost fishes and humans show a remarkable conservation in many developmental and physiological ...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2015.06.011
更新日期:2015-11-01 00:00:00
abstract::The influence of daily injections, for 7 days, of 17-hydroxyprogesterone caproate (8 mg/100 g body weight pro die), of estradiol-17 beta 17-undecylate (1.2 mg/100 g body weight pro die) of testosterone enanthate (2 mg/100 g body weight pro die) and of ACTH (4 IU/100 g body weight pro die) to male Wistar rats, weighing...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90016-7
更新日期:1981-07-01 00:00:00
abstract::While the neuroprotective benefits of estrogen and progesterone in critical illness are well established, the data regarding the effects of androgens are conflicting. Surgical repair of congenital heart disease is associated with significant morbidity and mortality, but there are scant data regarding the postoperative...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.11.003
更新日期:2014-03-01 00:00:00
abstract::Steroidal nucleoside analogs were synthesized starting from testosterone. By reduction of the oxime of 17 beta-hydroxy-androst-4-en-3-one (testosterone), a mixture of the two amino epimers of C-3 were obtained. The 3 alpha-amino-androst-4-en-17 beta-ol was crystallized in 73% yield and coupled with 5-amino-4,6-dichlor...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(01)00157-x
更新日期:2002-03-01 00:00:00
abstract::Fast atom bombardment/mass spectrometry or liquid secondary ion mass spectrometry provides the capability for direct analysis of steroid conjugates (sulfates, glucuronides) without prior hydrolysis or derivatization. During the analysis of biologic extracts, limitations on the sensitivity of detection arise from the p...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/0039-128x(90)90014-3
更新日期:1990-10-01 00:00:00
abstract::A short and efficient synthesis of steroid synthons, di(tert-butyldimethylsilyl) ethers of 3,21-dihydroxy-24-nor-chol-5-en-23-al (8 and 10) and of ethyl 3,21-dihydroxy-25-homo-chola-5,23-dien-25-oate (9 and 11), having natural (20R) and unnatural (20S) configuration from 3β-(tert-butyldimethylsilyloxy)-14α,20ξ-card-5-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.01.010
更新日期:2011-04-01 00:00:00
abstract::Over the past 30 years, numerous studies in invertebrates and vertebrates have established a role of calcium in oocyte maturation as well as in the resumption and progression of follicular development. Polycystic ovarian syndrome (PCO) is characterized by hyperandrogenic chronic anovulation, theca cell hyperplasia, an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00012-4
更新日期:1999-06-01 00:00:00
abstract::We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3 beta, 22-diol-3 beta-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3 beta-acetate 3 and (E) 22-dehydrocholest-5-en-3 beta-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixture of the ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(86)90044-9
更新日期:1986-07-01 00:00:00
abstract::Adrenal function and aging have been the object of intense interest in recent years. In this study we analyzed morning (08:00 h) serum cortisol concentrations from a sample of Chinese subjects aged from 31 to 110 years. These levels differed according to age, health status and sex, although the sex difference was conf...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(03)00083-7
更新日期:2003-08-01 00:00:00
abstract::For the study of hepatic bile acid transport in vivo, a series of modified bile salts were synthesized. The N-cholyl derivatives of L-leucine, L-alanine, D-alanine, beta-alanine, L-proline, and gamma-amino-butyric acid were prepared from cholic acid, ethyl chloroformate and the corresponding amino acid. Structural ana...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90007-7
更新日期:1983-02-01 00:00:00
abstract::The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection o...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(84)90023-0
更新日期:1984-06-01 00:00:00
abstract::Glucocorticoids are well-recognized modulators of immunocytes and osteoblasts via specific receptor-mediated mechanisms. We have evaluated the in vitro effect of interleukin 2 (IL-2) on the expression of glucocorticoid receptors (GRs) in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors and osteo...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(98)00023-3
更新日期:1998-05-01 00:00:00
abstract::During our studies of the hepatic androgen receptor in cynomolgus monkeys, tritiated mibolerone +/- a 200-fold excess of unlabeled mibolerone has been used to determine specific binding in cytosol. During time-course studies, high-capacity, unsaturable binding of [3H]mibolerone was noted after short-term incubations (...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(95)00116-8
更新日期:1995-11-01 00:00:00
abstract::Biotransformation of an orally active contraceptive drug, desogestrel (1), with Cunninghamella elegans yielded a new metabolite, 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17β-ol-3,6-dione (2), along with five known metabolites, i.e., 13β-ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-3β,6β,17β-triol...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2020.108694
更新日期:2020-10-01 00:00:00
abstract::Human keratinocytes convert 25(OH)D(3) to hormonally active 1alpha,25(OH)(2)D(3) and respond to its antiproliferative/prodifferentiating action in vitro and in vivo. Levels and activity of 1alpha,25(OH)(2)D(3) are short-lived. 1alpha,25(OH)(2)D(3) induces 24-hydroxylase (CYP24) that rapidly metabolizes the hormone, yi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00159-8
更新日期:2001-03-01 00:00:00
abstract::The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.07.009
更新日期:2007-11-01 00:00:00
abstract::Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. However, the importance o...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2009.11.005
更新日期:2010-08-01 00:00:00
abstract::Eleven new 14,15-seco-pregnane-type steroidal glycosides, cynanosides P1-P5, Q1-Q3, R1-R3, and a novel 12,13-seco-14,18-nor-pregnane-type steroidal glycoside, cynanoside S, were isolated from the roots of Cynanchum atratum, together with four known compounds, atratoside C, sublanceoside E3, chekiangensoside C and cyna...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.10.007
更新日期:2009-02-01 00:00:00