Twelve pregnane glycosides from Cynanchum atratum.

abstract：:A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 wa...

journal_title：Steroids

authors： Xia G,Li Y,Sun J,Wang L,Tang X,Lin B,Kang N,Huang J,Chen L,Qiu F

更新日期：2016-11-01 00:00:00

abstract：:The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...

journal_title：Steroids

authors： Zielinski J,Kokke WC,Fenical W,Djerassi C

更新日期：1982-10-01 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) is a major mediator in the pathophysiology, and pathogenesis of gynecological diseases associated with abnormal endometrial disease with proliferation and inflammation, such as endometriosis. In this study, we investigated the effect of dienogest, a selective progesterone receptor agonist, ...

journal_title：Steroids

authors： Shimizu Y,Mita S,Takeuchi T,Notsu T,Mizuguchi K,Kyo S

更新日期：2011-01-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...

journal_title：Steroids

authors： Gocek E,Kiełbiński M,Wyłób P,Kutner A,Marcinkowska E

更新日期：2008-12-22 00:00:00

abstract：:20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was...

journal_title：Steroids

authors： Temirgaziyev BS,Kučáková K,Baizhigit YA,Jurášek M,Džubák P,Hajdúch M,Dolenský B,Drašar PB,Tuleuov BI,Adekenov SM

更新日期：2019-07-01 00:00:00

abstract：:Using beta-sitosterol as a starting material, (6E)-hydroximino-24-ethylcholest-4-en-3-one (1), a natural steroidal oxime from Cinachyrella alloclada and C. apion, was synthesized in four steps with a high overall yield. First, beta-sitosterol (5a) is transformed into the corresponding 24-ethylcholest-4-en-3,6-dione (6...

journal_title：Steroids

authors： Cui J,Huang L,Fan L,Zhou A

更新日期：2008-03-01 00:00:00

abstract：:Sex steroid-binding protein receptor was detected on membranes prepared from human premenopausal endometrium. The binding of sex steroid-binding protein to membranes was specific, saturable, and high affinity. Scatchard analysis showed the presence of two binding sites at different affinities. The addition of estradio...

journal_title：Steroids

authors： Fortunati N,Fissore F,Fazzari A,Berta L,Giudici M,Frairia R

更新日期：1991-06-01 00:00:00

abstract：:26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25...

journal_title：Steroids

authors： Komuro S,Kanamaru H,Nakatsuka I,Yoshitake A

更新日期：1998-10-01 00:00:00

abstract：:The 21-hydroxy analogues of 11,19-oxidoprogesterone and 6,19-oxidoprogesterone have been synthesized from readily available materials. Hydroxylation at C-21 was effected with iodosobenzene (from phenyliodosodiacetate and methanolic potassium hydroxide) on a 20-ketopregnane. For the 11,19-oxido derivative, the hydroxyl...

journal_title：Steroids

authors： Veleiro AS,Nevado MV,Monteserín MC,Burton G

更新日期：1995-03-01 00:00:00

abstract：:3 alpha-Hydroxysteroid dehydrogenase (3 alpha HSD) is one of the main enzymes involved in the metabolism of the active androgen, dihydrotestosterone (DHT). 3 alpha HSD catalyzes the reversible reduction of DHT to 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha DIOL). The equilibrium of 3 alpha HSD reductive and oxid...

journal_title：Steroids

authors： Pirog EC,Collins DC

更新日期：1994-04-01 00:00:00

abstract：:Glucocorticoid receptor binding was compared in liver cytosol preparations from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using homologous displacement of [3H]dexamethasone. At 5 degrees C, there was no difference in receptor binding affinity or concentration between strains for dexamethasone, ...

journal_title：Steroids

authors： Panarelli M,Holloway CD,Barr AB,Fraser R,Kenyon CJ

更新日期：1995-01-01 00:00:00

abstract：:Three BS-BODIPY (brassinosteroids-4,4-difluoro-4-bora-3a,4a-diaza-s-indacene) conjugates were synthesized and their fluorescent and immunological properties were investigated. Two of the conjugates, having present all the functional groups characteristic of BS, were shown to be potentially useful as biological probes ...

journal_title：Steroids

authors： Malachowska-Ugarte M,Sperduto C,Ermolovich YV,Sauchuk AL,Jurášek M,Litvinovskaya RP,Straltsova D,Smolich I,Zhabinskii VN,Drašar P,Demidchik V,Khripach VA

更新日期：2015-10-01 00:00:00

abstract：:Labeled beta-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of beta-muri...

journal_title：Steroids

authors： Sacquet E,Parquet M,Riottot M,Raizman A,Nordlinger B,Infante R

更新日期：1985-05-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:A direct competitive heterologous enzyme-linked immunosorbent assay (ELISA) was developed and validated to determine follicular fluid estradiol levels of different antral follicular sizes (small, medium, and large) obtained from the ovaries of heifers in the follicular phase of the estrous cycle. Polyclonal antiestrad...

journal_title：Steroids

authors： Silván G,Illera JC,Illera M

更新日期：1993-07-01 00:00:00

abstract：:From the fruiting bodies of Ascomycetes Tuber indicum, a new steroidal glucoside with polyhydroxy ergosterol nucleus, tuberoside (2), has been isolated along with additional four known ergosterol derivatives, (22E, 24R)-ergosta-7, 22-dien-3beta, 5alpha, 6beta-triol (1), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6, 22...

journal_title：Steroids

authors： Jinming G,Lin H,Jikai L

更新日期：2001-10-01 00:00:00

abstract：:The synthesis of 13C-labeled steroid hormones is reviewed. Two general approaches are highlighted: partial synthesis in which part of the steroid nucleus is replaced with 13C-labeled synthons, and total synthesis. Examples from both approaches, leading to (3-(3)C)-, (4-(13)C)-, (3,4-(13)C2)-, and (1,2,3,4-(13)C4)- lab...

journal_title：Steroids

authors： Zomer G,Stavenuiter JF

更新日期：1990-10-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...

journal_title：Steroids

authors： Huerta-García E,Ventura-Gallegos JL,Victoriano ME,Montiél-Dávalos A,Tinoco-Jaramillo G,López-Marure R

更新日期：2012-02-01 00:00:00

abstract：:A virulent culture of Hymenoscyphus fraxineus, the causal agent of ash dieback, was investigated for its production of secondary metabolites in a 70 L batch fermentation. Chemical analysis of the mycelial extract by means of flash chromatography and preparative HPLC led to the isolation of a new ergostane-type steroid...

journal_title：Steroids

authors： Surup F,Halecker S,Nimtz M,Rodrigo S,Schulz B,Steinert M,Stadler M

更新日期：2018-07-01 00:00:00

abstract：:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...

journal_title：Steroids

authors： Key TJ

更新日期：2011-07-01 00:00:00

abstract：:Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. At 0 degrees C apparent equilibrium of ...

journal_title：Steroids

authors： Zakár T,Tóth M

更新日期：1977-12-01 00:00:00

abstract：:Following i.v. administration of [4-14C]cortisol, various sulfate conjugated metabolites of cortisol in urine were identified and their respective excretion rates measured. The results obtained demonstrated the following: 1) sulfate conjugates as a group are excreted considerably slower than glucuronide conjugates; 2)...

journal_title：Steroids

authors： Kornel L,Miyabo S

更新日期：1975-06-01 00:00:00

abstract：:A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trilliu...

journal_title：Steroids

authors： Shafiq-ur-Rahman,Ismail M,Shah MR,Adhikari A,Anis I,Ahmad MS,Khurram M

更新日期：2015-12-01 00:00:00

abstract：:Estradiol benzoate (EB) has been one of the most widely used estrogenic agents in animal husbandry, as a way of exogenously introducing the natural hormone estradiol-17β into the animal organism. Estradiol was previously employed to induce anabolic effects or reproductive improvements in cattle. However, the employmen...

journal_title：Steroids

authors： Regal P,Nebot C,Díaz-Bao M,Barreiro R,Cepeda A,Fente C

更新日期：2011-03-01 00:00:00

abstract：:The enterohepatic circulation and metabolism of ethynodiol diacetate (3beta,17beta-diacetoxy-17alpha-ethynyl-estr-4-ene) in baboons were studied following the intravenous injection of this contraceptive steroid labeled with 14C (4-position) and with 3H (in either the 3- or 17-acetoxy moieties). Bile and urine from fou...

journal_title：Steroids

authors： Ishihara M,Osawa Y,Kirdani RY,Sandberg AA

更新日期：1975-06-01 00:00:00

abstract：:The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...

journal_title：Steroids

authors： Timsit YE,Negishi M

更新日期：2007-03-01 00:00:00

abstract：:Recent studies by several research groups have shown that G protein estrogen receptor-1 (GPER) formerly known as GPR30, mediates 17beta-estradiol (E2) activation of signal transduction pathways in a variety of human cancer cells and displays E2 binding typical of a membrane estrogen receptor. However, the importance o...

journal_title：Steroids

authors： Thomas P,Alyea R,Pang Y,Peyton C,Dong J,Berg AH

更新日期：2010-08-01 00:00:00

abstract：:In comparison with the glucocorticoids cortisol and corticosterone, the mineralocorticoid aldosterone is a minority hormone of the mammalian adrenal cortex, and its proper function is dependent upon protective physiological mechanisms. These include a particular site of aldosterone synthesis in zona glomerulosa cells ...

journal_title：Steroids

authors： Müller J

更新日期：1995-01-01 00:00:00

abstract：:The first convenient chemical synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione is reported. Androsta-4,6-diene3, 17-dione was converted into its 6alpha, 7alpha-epoxy-derivative; reduction of the epoxide with aluminum amalgam gave 7alpha-hydroxyandrost-4-ene-3,17-dione. This reducing agent is more efficient than chr...

journal_title：Steroids

authors： Hossain AM,Kirk DN,Mitra G

更新日期：1976-05-01 00:00:00

abstract：:13beta-Ethyl-3-methoxy-17beta-ol-8,14-seco-1,3,5(10),8-gonatetraen-14-one (IIIa) was isolated and its participation in the well-known acidic cyclization process was established. ...

journal_title：Steroids

authors： Makk N,Tóth G,Tömörkény E

更新日期：1975-05-01 00:00:00